Current Research Studies
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HIV CURE
A5321: Decay of HIV-1 Reservoirs in Patients on Long-Term Antiretroviral Therapy: The ACTG HIV Reservoirs Cohort (AHRC) Study. Closed to enrollment.
A5354 (Cure TSG): Effect of antiretroviral treatment initiated during Acute HIV-1 Infection on measures of HIV-1 persistence and on HIV-1 specific immune response.
A5374: A Phase I/IIa Randomized, Placebo-Controlled Trial of Conserved-Mosaic T-cell Vaccine in a Regimen with Vesatolimod and Broadly Neutralizing Antibodies in Adults Initiated on Suppressive Antiretroviral Therapy during Acute HIV-1.
HIV Comorbidities and complications
A5128: Plan for Obtaining Informed Consent to Use Stored Human Biological Materials (HBM) for Currently Unspecified Analyses
A5355: Phase II, Double-Blind, Randomized, Placebo-Controlled Trial to Evaluate the Safety and Immunogenicity of a Modified Vaccinia Ankara (MVA)-based anti-Cytomegalovirus (CMV) Vaccine (Triplex®), in Adults with Both Human Immunodeficiency Virus (HIV)-1 and CMV Who Are on Potent Combination ART with Conserved Immune Function.
A5391 (ARTS TSG): Effect of a Switch to Doravirine Among Persons with Excessive Weight Gain on Integrase Inhibitors and Tenofovir Alafenamide Fumarate.
A5403: Giving Standardized Estradiol Therapy In Transgender Women to Research Interactions with HIV Therapy: the GET IT RIgHT Study.
A5415 (CTSG): A Limited-Center, Prospective, Double-Blind, Placebo-Controlled Study to Evaluate the Effects of Cenicriviroc Mesylate on Arterial Inflammation in People Living with HIV.
Tuberculosis
A5372 (TB TSG): (LTBI/HIV RPT-DTG PK): Drug-Drug Interactions Between Rifapentine and Dolutegravir in HIV/LTBI Co-Infected Individuals.
Mpox
A5418: A Randomized, Placebo-Controlled, Double-Blinded Trial of the Safety and Efficacy of Tecovirimat for the Treatment of Human Monkeypox Virus Disease Study of Tecovirimat for Human Monkeypox Virus (STOMP).
HIV Treatment
A5359 (ARTS TSG): A Phase III Study to Evaluate Long-Acting Antiretroviral Therapy in Non-adherent HIV-Infected Individuals.
Hepatitis: Prevention & Treatment
A5379 (Hepatitis TSG): B-enhancement of HBV vaccination in persons living with HIV (BEe-HIVe): A Randomized, Controlled Trial of HEPLISAV-B vs. Engerix-B.
A5394.(Hepatitis TSG): Safety, Tolerability, and Impact of Oral TLR8 Agonist Selgantolimod on HBsAg in Participants with Both Chronic Hepatitis B and HIV.
Non-ACTG Research Studies
GSK 209639 EMBRACE: A Phase 2b Multicenter, Randomized, Open-Label Study Comparing the Efficacy, Safety, PK, and Tolerability of VH3810109, Administered Either Intravenously or As A Subcutaneous Infusion with rHuPH20, in Combination with CAB LA to Standard of Care in Virologically Suppressed Adults Living with HIV.
Doxycycline for Emphysema in People Living with HIV (The DEPTH Trial): Phase II, multicenter, randomized, double-blinded, placebo-controlled clinical trial of doxycycline for 72 weeks for emphysema