Addiction and Substance Use Studies

Pioglitazone with Cognitive-Behavioral Therapy for Cocaine Relapse Prevention

The purpose of this study is to see how well pioglitazone improves the chances of recovery in people who have recently stopped using cocaine when combined with a type of talk therapy called cognitive behavioral therapy (CBT).

Exenatide with Nicotine Patch for Smoking Cessation and Prevention of Post-Cessation Weight Gain

The purpose of this study is to determine if exenatide – an FDA-approved drug for glycemic control – increases the number of people who successfully quit smoking at the end of their treatment and helps with reducing post-cessation weight gain.

Suvorexant to Reduce Symptoms of Nicotine Use

Researchers want to investigate whether this medication could be beneficial for people who want to quit smoking and assess its impact on relapse risks such as cravings, withdrawal symptoms, and stress reactivity.

Abstinence from Cannabis Use on Symptoms of Distress, Inflammation, and HIV viral load

This study aims to explore the feasibility and impact of 28-days of monitored abstinence from cannabis on people living with HIV, who use cannabis weekly or more often.

Effects of Pioglitazone on Stress Reactivity and Alcohol Craving

This study aims to investigate how pioglitazone affects the risk of relapse triggered by stress, its effects on drinking behavior, stress/anxiety, and alcohol cravings in real-life situations for persons with excessive alcohol use.

Combined Naltrexone and Bupropion Effects on Methamphetamine Use and Cigarette Smoking

The purpose of this study is to investigate the effects of naltrexone-bupropion combination pharmacotherapy on smoking behavior and METH use, to test efficacy, and examine drug craving and reward mechanisms.

Circuitry-Guided Smoking Cessation in Schizophrenia

The purpose of this study is to investigate TMS treatment options for people with schizophrenia spectrum disorders who want to quit smoking.