Neuropsychiatry Program (NPP)

The Neuropsychiatry Program (NPP) develops basic and clinical research aiming to understand the neurobiological basis of behavioral syndromes (e.g. apathy, depression), especially in the context of neurodegenerative diseases, including Alzheimer’s and Huntington’s diseases. Among putative pathophysiological mechanisms, the NPP is particularly interested in investigating the role played by immune and inflammatory mechanisms.

Led by Antonio L. Teixeira, MD, PhD, and grounded in robust basic and clinical components, the NPP is currently developing the following studies:

  • ‘ABCDE-LS’, a naturalistic follow-up study of cognitive and behavioral domains in older adults;
  • Multiple biomarkers (blood-based, neuroimaging, electrophysiological) of apathy in older adults;
  • Immune biomarkers across neurodegenerative conditions – Alzheimer’s disease, Huntington’s disease, HIV-associated neurocognitive disorder.
  • Modeling behavioral syndromes in rodent models of neurodegenerative conditions (Alzheimer’s disease and stroke).

The Neuropsychiatry Program has established research collaborations with other Houston-based programs from UTHealth, UT MD Anderson, the University of Houston, and researchers around the world, including Brazil and the United Kingdom. Those who are interested in this research are invited to contact Dr. Teixeira for research opportunities and collaborations.