Protein Misfolding Laboratory

Our research is focused into the molecular basis of neurodegenerative diseases associated to the misfolding and brain accumulation of proteins, particularly focusing in Alzheimer’s and prion-related disorders. Soto Research DiagramOur work includes basic science projects as well as translational research aimed to the development of novel strategies for treatment and diagnosis of these diseases.

Recently, we have also become interested in the identification of non-disease-associated protein undergoing misfolding and aggregation as part of the normal biological function of the protein. The expansion of the amyloid and prion concepts towards many other proteins might revolutionize our understanding of biology.