Completed Clinical Trials

  • Lymphatic Contribution to Progressive Peripheral Vascular Disease and Ulceration 
    Co-PI: Harlin
    Status: Active & Enrolling
    Synopsis: Synopsis: To determine the association if any between early stage lower extremity venous reflux or peripheral arterial disease with lymphatic disease.
  • LEOPARD: Multicenter, Observational, Post-Market, Real-World Study to Assess Outcomes of Patients Treated with the AFX® System Compared to other EVAR Devices for Endovascular Abdominal Aortic Aneurysm Repair LEOPARD: Looking at EVAR Outcomes by Primary Analysis of Randomized Data.
    PI: Harlin
    Status: Active, Not Enrolling
    Synopsis: The objective of this post-market multicenter randomized observational study is to evaluate Endologix AFX endovascular AAA system with anatomical fixation against other approved Endovascular systems with proximal fixation.
  • PAIN (Postoperative Analgesia INvestigation)
    PI: Charlton-Ouw
    Synopsis: A randomized controlled trial evaluating efficacy of local anesthetics in managing perioperative pain
  • Plasma DNA Study
    PI: Banki
    Synopsis: This study evaluates plasma DNA in patients with thoracic malignancies and with visceral malperfusion
  • IVC Filter Retrieval Program
    PI: Charlton-Ouw
    Synopsis: A prospective research and quality improvement project analyzing the efficacy and cost-effectiveness of a dedicated IVC filter retrieval team
  • SAPPHIRE (Stenting and Angioplasty with Protection in Patients at High Risk for Endarterectomy)
    PI: Azizzadeh
    Synopsis: This study tracks outcomes in patients after carotid artery angioplasty and stenting
  • Medtronic DISSECTION Trial
    PI: Azizzadeh
    Synopsis: Evaluation of the Medtronic Valiant Thoracic Stent-Graft for acute complicated type B aortic dissection
  • Medtronic RESCUE Trial
    PI: Azizzadeh
    Synopsis: Evaluation of Medtronic Valiant Thoracic Stent-Graft for Traumatic Aortic Injury
  • Plasma DNA in Organ Malperfusion
    PI: Banki
    Synopsis: Evaluating plasma DNA in patients who develop organ malperfusion syndrome after surgical repair for aortic aneurysm or dissection
  • Figure 8 study (Multi-Center Prospective Study to Demonstrate the Usability, Safety and Efficacy of the Figure 8 Surgical Sternotomy Closure Device)
    PI: Estrera
    Synopsis: The purpose of this study is to demonstrate the Figure 8 Surgical Sternotomy Closure Device is safe, effective and easy to use for closing the sternum after a heart or lung surgical procedure. 
  • PRICE (Propaten Randomized Investigation on Cost-benefit and Efficacy)
    PI: Charlton-Ouw
    Synopsis: A randomized controlled trial to evaluate the efficacy of anticoagulant bonded hemodialysis arteriovenous grafts
  • Gore CTAG Aneurysm Trial
    PI: Estrera
    Synopsis: Evaluation of the Gore CTAG Endoprosthesis for descending thoracic aortic aneurysms
  • Gore CTAG Trauma
    PI: Azizzadeh
    Synopsis: Evaluation of the Gore CTAG Endoprosthesis for traumatic aortic injury
  • HARVEST
    PI: Charlton-Ouw
    Synopsis: Pivotal Study of the Safety and Effectiveness of Autologous Bone Marrow Aspirate Concentrate (BMAC) for the treatment of Critical Limb Ischemia due to Peripheral Arterial Occlusive Disease
  • Specialized Center for Clinically-Oriented Research in Aortic DiseasesWe are actively involved in the NIH-funded specialized center grant (SCCOR) in collaboration with Dr. Dianna Milewicz in the Department of Medicine. Drs. Safi and Estrera are co-investigators on the main clinical project, and Dr. Miller is Principal Investigator of the Biostatistics core.  This project has total direct costs of approximately $6 million and is already producing major findings such as those reported recently in Nature Genetics.