Rhoads-Liu Lab

pediatric GI group pictures 2020

In this picture from left to right: Shabba Armbrister, Yuying Liu, Dr. Rhoads, Tu Mai and Nicole Fatheree.

The goal of our research is to identify the role of probiotics and other gut microbial factors in the regulation of immune-related disorders that affect the gastrointestinal tract. We have identified shifts in the balance of effector and regulatory T cells in several mouse models of human disease, including necrotizing enterocolitis, IPEX syndrome, and a model of multiple sclerosis. We have identified a receptor for probiotic Lactobacillus reuteri on intestinal epithelial cells (TLR2) and a novel mechanism for control of multisystem inflammation (via generation of adenosine interacting with the A2A receptor). A recent focus has been on microbial metabolites that are mechanistically linked to the anti-inflammatory effects of probiotic(s).

We also are actively involved in several human studies, several related to the microbiome, including an investigation of a combination probiotic for children with autism spectrum disorder with gastrointestinal symptoms.

Contact Information

6431 Fannin Street | MSB 3.140 lab | Houston, TX 77030
713-500-5747 lab