PCD & Transcriptomics

Pediatrics Allergy & Immunology Collaborative Research

This project is conducted in collaboration with Ricardo A. Mosquera, MD, MS, Professor and Division Director of Pediatric Pulmonary & Sleep Medicine. The study focuses on inflammatory transcriptomic profiling to better define endotypes in primary ciliary dyskinesia(PCD), using comparisons with both healthy individuals and patients with non-cystic fibrosis bronchiectasis. The goal is to advance understanding of airway inflammation and identify potential targets for improved diagnosis and management.

Mosquera RA, Magana-Ceballos IG, De Jesus Rojas W, Huang X, Koochak H, Tellez ME, Castillo-Moguel JA, Bishehsari F, Mahdavinia M, Ramos-Benitez MJ, Harris T, Yadav A, Owens K, Lemus-Rangel R, Romero M, Zuleta S, Luz A, Baltazar-Fernandez A, McBeth KE, Hashmi S, Rosario Ortiz G, Santoyo-Rios J, Loyo-Rodriguez JF, Colasurdo GN. Multi-Omics Analysis Defines Endotypes and Systemic Inflammation in Primary Ciliary Dyskinesia: A Comparison with Healthy Controls (external link). Ann Am Thorac Soc. 2026 Jun 8:aaoag152. doi: 10.1093/annalsats/aaoag152. Epub ahead of print. PMID: 42258623.