John P. Seymour, PhD

D. Yan, T.M. Bruns, Y. Wu, L. Zimmerman, C. Stephan, Y. Cheng, A.P. Cameron, E. Yoon, J.P. Seymour, “Ultra-compliant carbon nanotube stretchable electronics direct bladder interface” in press at Adv. Healthcare Materials

Mendrela AE, Kim K, English D, McKenzie S, Seymour JP, Buzsáki G, et al. A High-Resolution Opto-Electrophysiology System with a Miniature Integrated Headstage. IEEE Trans Biomed Circuits Syst. 2018 (link)

Sperry ZJ, Na K, Parizi SS, Chiel HJ, Seymour J, Yoon E, Bruns TM. Flexible microelectrode array for interfacing with the surface of neural ganglia. Journal of neural engineering. 2018 Apr 16;15(3):036027. (link)

Komal Kampasi, English DF, Seymour J, Stark E, McKenzie S, Vöröslakos M, et al. Dual color optogenetic control of neural populations using low-noise, multishank optoelectrodes. Microsystems Nanoeng. 2018;(link).

S.M. Wellman, J.R. Eles, K.A. Ludwig, J.P. Seymour, N.J. Michelson, W.E. McFadden, A.L. Vazquez, T.D.Y. Kozai, “A Materials Roadmap to Functional Neural Interface Design,” Advanced Functional Materials, 2017, 1701269. (link)

J.P. Seymour*, F. Wu, K.D. Wise, E. Yoon, “State-of-the-art MEMS and microsystem tools for brain research,” Microsystems and Nanoengineering, 16066, 2017. (link)

K. Kampasi, E. Stark, J. Seymour, K. Na, H. G. Winful, G. Buzsáki, K. D. Wise, and E. Yoon, “Fiberless multicolor neural optoelectrode for in vivo circuit analysis,” Scientific Reports, vol. 6, 2016. (link)

T.D.Y. Kozai, K. Catt, Z. Du, K. Na, O. Srivannavit, R.M. Haque, J. Seymour, K.D. Wise, E. Yoon, and X. T. Cui, “Chronic in vivo evaluation of PEDOT/CNT for stable neural recordings,” IEEE Trans. Biomed. Eng., vol. 63, no. 1, pp. 111–119, 2016. (link)

J.P. Seymour*, N. Langhals, D.J.Anderson, D.R. Kipke;  “Novel multi-sided, microelectrode arrays for implantable neural applications,”  Biomed Microdevices, 2011. 13(3): p. 441-51. (link)

J.P. Seymour*, Y. Elkasabi, H. Chen, J. Lahann, and D.R. Kipke; “Improved insulation performance in bioelectrical devices with a reactive parylene interface,” Biomaterials; 2009; 30(31): 6158-6167. (link)

E.K. Purcell, J.P. Seymour, S. Yandamuri, D.R. Kipke, “In vivo evaluation of a neural stem cell-seeded probe.” Journal of Neural Engineering; 2009; Apr; Issue 2.  (link)

J.P. Seymour and D.R. Kipke; “Neural probe design for reduced tissue encapsulation in CNS,” Biomaterials; 2007; Sep; 28(25):3594-3607. (link)

Peer-Reviewed Conference Proceedings

D. Yan, A. Jiman, D. Ratze, S. Huang, E. Welle, P. Patel, A. Ouyang, M. Kushner, C. Chestek, T. Bruns, E. Yoon, J. Seymour*, “Microneedle Penetrating Array with Axon-Sized Dimensions for Cuff-less Peripheral Nerve Interfacing” IEEE EMBS NER Conference 2019, Mar. 2019; San Francisco, CA

D. Yan, J. Seymour, C. Stephen, A. Mundorf, Y. Cheng, T. Bruns, E. Yoon, “Highly stretchable implantable device for bladder volume monitoring and stimulation”, Materials Research Society, Nov. 26 2017; Boston, MA

A. E. Mendrela, K. Kim, D. English, S. McKenzie, J. Seymour, G. Buzsáki E. Yoon, “A Miniature Headstage for High Resolution Closed-Loop Optogenetics”, 2017 IEEE Biomedical Circuits & Systems Conference, 2017 Oct. 19-21; Turin, Italy

K. Kim, D. English, S. Mckenzie, F. Wu, E. Stark, J. Seymour, P. Ku, K. Wise, G. Buzsaki, and E. Yoon, “GaN-on-Si μ LED optoelectrodes for high-spatiotemporal-accuracy optogenetics in freely behaving animals,” IEEE Int. Electron Devices Meet., 2016.

K. Kampasi, J. Seymour, E. Stark, G. Buzsáki, K. D. Wise, and E. Yoon, “Efficient assembly of multi-color fiberless optoelectrodes with on-board light sources for neural stimulation and recording,” in Conference of the IEEE Engineering In Medicine And Biology Society (EMBC), 2016.

K. Kampasi, J. P. Seymour, K. Na, K. D. Wise, and E. Yoon, “Fiberless multicolor optoelectrodes using injection laser diodes and gradient-index lens coupled optical waveguides,” in Transducers, 2015.

A. Khurram and J. P. Seymour*, “Investigation of the photoelectrochemical effect in optoelectrodes and potential uses for implantable electrode characterization.” EMBC 2013. The 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society; 2013 July 3-7; Osaka, Japan.

D.R. Kipke, GJ Gage, EK Purcell, J.P. Seymour, J Subbaroyan, TC Marzullo, “Development of neural interfaces for chronic use in neuromotor prosthetics,” IEEE 10th International Conf. on Rehabilitation Robotics

J.P. Seymour, D.R. Kipke; ” Open-Architecture Neural Probes Reduce Cellular Encapsulation,” Materials Research Society Symposium Proc. Vol. 926, pp. 6, San Francisco 2006.

J. P. Seymour and D. R. Kipke, “Fabrication of polymer neural probes with sub-cellular features for reduced tissue encapsulation,” Annu. Int. Conf. IEEE Eng. Med. Biol. – Proc., vol. 1, pp. 4606–4609, Jan. 2006.

Select Conference Abstracts

Dongxiao Yan, Ahmad Jiman, Paras Patel, David Ratze, Elizabeth Bottorff, Elissa Welle, Zhonghua Ouyang, Daniel Ursu, Hannah Parrish, Stephen Kemp, Cynthia Chestek, Tim Bruns, Euisik Yoon, J. Seymour, “A high-density tool for the autonomic nervous system: MIcroneedle Nerve Array (MINA) demonstrated in the rat cervical vagus nerve”, International Society of Autonomic Neuroscience (ISAN 2019), Jul. 25-27, 2019, Los Angelos, CA

M. Madias, Z. Chen, P. Rioja, M. Voroslakos, and E. Yoon, J. Seymour, “A Closed Loop System for Juxtacellular Pipette Recordings on a Freely-Moving Animal,” 2018 Annual Biomedical Research Conference for Minority Students (ABRCMS), Nov. 14-17, 2018, Indianapolis, IN

B. Gregory, J. Salatino, M. Railing, T. O’Malley, J. Seymour, J. Beatty, C. Cox, E. Purcell, “Structural and functional changes of pyramidal neurons in primary motor cortex at the site of an implanted multielectrode array” Society for Neuroscience 2018 Meeting, San Diego, CA

C. Stephan, D. Yan, Y. Cheng, L. Zimmerman, A. Cameron, E. Yoon, J.P. Seymour, T. Bruns, “Development of A Stretchable Substrate For A Bidirectional Bladder Interface”, Biomedical Engineering Society 2017, Phoenix, Az.

Z.J. Sperry, K.Na, S. Parizi, H. Hilow, J.P. Seymour, E. Yoon, T.M. Bruns, “Detecting bladder afferent activity from the surface of sacral dorsal root ganglia with a non-penetrating thin-film electrode array,” Society for Neuroscience 2017 Meeting, Washington D.C.

Z.J. Sperry, H.J. Chiel, J.P. Seymour, H. Lu, C. Kehl, K. Na, E. Yoon, T.M. Bruns, “High-density extracellular recording from the buccal ganglia of Aplysia californica using a novel thin-film electrode array,” Society for Neuroscience 2016 Meeting, San Diego, CA, November 12-16.

Z.J. Sperry, J. P. Seymour, F. Wr, S. E. Ross, K. Kim, J. T. Bentley, E. Yoon, and T. M. Bruns, “Dorsal root ganglia neural recordings with a novel non-penetrating thin-film microelectrode array,” in Society for Neuroscience, 2015, p. 540.04/CC20.

JA Mack, SL Woo, JP Seymour, E Yoon, MG Urbanchek, PS Cederna, NB Langhals: Biocompatibility of Polydimethylsiloxane (PDMS) as an Electrode Substrate for the Re-generative Peripheral Nerve Interface (RPNI), IEEE Southeastern Michigan Fall Meeting, Sterling Heights, MI, {Best Poster Award}, 2014.

J.P. Seymour, N. Langhals, M.R. Adibian, D.R. Kipke; “Sub-cellular edge electrode increases viewing angle and decreases arbor damage,” Society for Neuroscience Poster/Abstract (Washington, D.C.); Nov. 2008; 862.4.

T. Moon, D.S. Pellinen, E.K. Purcell, J.P. Seymour, and D.R. Kipke; “Local Drug Delivery System for Dynamic Control of Neural Environment using Parylene-Based Microelectrodes,” World Congress on Medical Physics and Biomedical Engineering (Seoul, Korea); August, 2006.

J.P. Seymour and D.R. Kipke; “Biodegradable polymers for short-term drug delivery on neural microelectrodes,” Society for Neuroscience Poster/Abstract (San Diego, CA); October 2004; 902.11.

J.P. Seymour, Y. Elkasabi, H. Chen, J. Lahann, and D.R. Kipke; “Advanced Parylene Microelectrode Arrays: New Materials and Design Space for Microfabricated Neural Prostheses,” Neural Interfaces Conference (Cleveland, OH); June, 2008; Poster.

J.P. Seymour, E.K. Purcell, C. Bjornsson, J. Subbaroyan, D. Colesa, B. Pfingst, and D.R. Kipke; “A Method for In Situ Evaluation of Silicon Microelectrode Arrays,” Neural Interfaces Conference (Cleveland, OH); June, 2008; Poster

J.P. Seymour, H. Chen, Y. Elkasabi, J. Lahann, and D.R. Kipke; “Bioelectrical Performance of Microfabricated Parylene Substrates,” Materials Research Society (San Francisco, CA); March, 2008; BB210.

J.P. Seymour and D.R. Kipke; “Ultra-fine structures on neural probes reduce cellular encapsulation,” Society for Neuroscience Poster/Abstract (Atlanta,GA); October 2006; 354.16.

R.J. Vetter, J.P. Seymour, D.R. Kipke, et al; “A modular multiprobe cortical neuroprosthesis” Society for Neuroscience Poster/Abstract (Atlanta, GA); October 2006.

J.P. Seymour and D.R. Kipke; “Biodegradable Polymers for Short-term Drug Delivery on Neural Microelectrodes,” Society for Neuroscience Poster/Abstract (San Diego, CA); October 2004; 902.11.

Patents and Inventions

• J.P. Seymour, Nick Hewitt, Jongeun Jeon, “Opto-electrical device with artifact reduction”, Filed Jul. 2011, US Patent 9,782,091
• J.P. Seymour, Kc Kong, RJ Vetter; “Neuromodulation transfection system with active drug delivery”, Filed Jul. 2011, US Patent 9,700,736
• J.P. Seymour, M. Gulari, K.C. Kong, D.R. Kipke, “Waveguide neural interface device,” Filed Nov. 2009, US Patent 9,643,027
• D.R. Kipke, J.F. Hetke, R.J. Vetter, J.P. Seymour, “Implantable neural interface device with deformable carrier”, Mar. 22, 2016, U.S. Patent 9,289,151
• J.P. Seymour, D.R. Kipke, Joerg Lahann, M Gulari; “Method for manufacturing an implantable electrode device,”, Filed Nov. 2009. US Patent 8,561,292, 9,259,567
• J.P. Seymour, “Methods for forming an electrode device with reduced impedance”, Published 2015/11/24, US Patent 9,192,757
• J.P. Seymour, A. Khurram, “System and method for testing electrical circuits using a photoelectrochemical effect”, Publication date 2015/1/27, US Patent 8,941,390.
• J.P. Seymour, M. Gulari, K.C. Kong, D.R. Kipke, “Waveguide neural device,” Filed Nov. 2010, US Patent 8,870,857
• J.P. Seymour, J.F. Hetke, R.J. Vetter, D.R. Kipke, D. Pellinen, Kc Kong, “Neural interface system with an edge array”, Publication date 2015/4/14, US Patent 9,008,747
• D.J. Anderson, D.R. Kipke, J.F. Hetke, R.J. Vetter, Kc Kong, J.P. Seymour, “Hybrid clustered neural interface system”, Published 2015/2/10, US Patent 8,954,144
• D.R. Kipke, J.F. Hetke, R.J. Vetter, J.P. Seymour, “Implantable neural interface device with a connector having a slitted deformable section” Published 2015/3/3, US Patent 8,972,026
• J.P. Seymour, D.R. Kipke, “Microelectrode with laterally extending platform for reduction of tissue encapsulation”, Jun. 5, 2012. Filed Jan. 2007, US Patent 8,195,267.
• D.R. Kipke, J.F. Hetke, R.J. Vetter, J.P. Seymour, “Implantable neural interface device with a deformable carrier,” US Patent 8,958,890