Will Erwin Headache Research Center (WEC)
The Will Erwin Headache Research Center, led by Dr. Mark Burish, aims to understand the mechanisms underlying headache and facial pain disorders. Progress in the research of many of these disorders has been limited by the lack of diagnostic tests, few good animal models, and the rarity of many of the diseases. At the same time, a wide range of new devices and antibody-targeted drugs has opened up the possibility of many new treatment options. Our focus is clinical research, in studying patients. We study the molecular and physiological basis of these diseases, and hope to provide a link to basic science research and treatment trials for them.
The Will Erwin Headache Research Center is associated with the Will Erwin Headache Research Foundation, a non-profit organization with the goal of finding cures for debilitating headaches. For more details on the work of the Will Erwin Headache Research Foundation, click here.
Dr. Mark Burish, MD, PHD, is an associate professor in the Vivian L. Smith Department of Neurosurgery at the McGovern Medical School at UTHealth Houston, where he also serves as a neurologist and interventional pain specialist. He obtained his MD and PhD at Vanderbilt University, where his research focused on brain mapping of motor and somatosensory systems including studies on how the central nervous system adapts after injury.
His neurology and pain management training was at the University of California at San Francisco, where his treatment of patients led to an interest in headache and pain. He is currently collaborating with Dr. Seung-Hee Yoo and her team at McGovern Medical School for ongoing headache research.
Clinical research (research with patients)
- Clinical trial of Vitamin D
- Online treatment survey in collaboration with Clusterbusters
- Phone call and online survey: headache registry of patients with trigeminal autonomic cephalalgias including cluster headache
Cluster headache is also known as suicide headache or Horton’s syndrome. The intensity of the pain is suspected to among the worst that humans can experience. It is part of the trigeminal autonomic cephalalgia (TAC) group of headaches, which are a group of primary headache disorders characterized by one-sided forehead or eye pain that is usually accompanied by ipsilateral cranial autonomic features like a red eye, watery eye, droopy eyelid, runny nose, or nasal congestion. The headache is known for its “clock-like” predictability, and we have been studying that clock-like pattern in our collaboration with Dr. Seung-Hee Yoo and her team.
- Phone call and online survey: headache registry of patients with trigeminal autonomic cephalalgias including hemicrania continua
Hemicrania continua is characterized by constant pain on one side of the head that, when it flares up, is usually accompanied by ipsilateral cranial autonomic features like a red eye, watery eye, droopy eyelid, runny nose, or nasal congestion. Hemicrania continua responds very well to treatment with indomethacin. It is a rare headache and is also part of the trigeminal autonomic cephalalgia (TAC) group of headaches.
Time-dependent Headache Medication Effectiveness Study:
Most patients with cluster headache experience the episodic form, in which headaches occur at least every other day for weeks to months before ceasing for at least 3 consecutive months each year. Patients typically start treatments when their headaches begin and discontinue them when the headaches subside.
This study does not introduce new treatments for cluster headache. Rather, it aims to monitor patients’ typical treatments throughout one headache cycle. This study differs itself from other surveys and clinical trials by focusing on several other factors like timing, doses, and effectiveness across different medications that can then be compared. Participation involves an initial online survey followed by a 3-week-long daily online headache diary to record headache occurrences.
To qualify you must:
- Be at least 18 years of age
- Have episodic cluster headache
- Have headaches that will last at least 3 more weeks (based on how long your headache cycles usually last)
If you are interested in the Vitamin D study for cluster headache, please contact the research team at (713) 486-7771 or email us at email@example.com for more information.
The enrollment process will require a 15-minute initial phone call with the study coordinator or a research nurse after completing the initial interest survey, followed by a 30-minute phone call with the principal investigator Dr. Mark Burish, if necessary.
- Phone call and online survey: headache registry of patients with trigeminal autonomic cephalalgias including paroxysmal hemicrania
Paroxysmal hemicrania is characterized by sudden, brief, reoccurring, and high-frequency (5 or more episodes a day) attacks on one side of the head. It is also characterized by one-sided forehead or eye pain that is usually accompanied by ipsilateral cranial autonomic features like a red eye, watery eye, droopy eyelid, runny nose, or nasal congestion. It is a rare headache and is also part of the trigeminal autonomic cephalalgia (TAC) group of headaches.
SUNCT or SUNA (Short-Lasting Unilateral Neuralgiform Headache with Conjunctival Injection and Tearing or Short-Lasting Unilateral Neuralgiform Headache Attacks with Cranial Autonomic Symptoms):
- Phone call and online survey: headache registry of patients with trigeminal autonomic cephalalgias including SUNCT and SUNA
SUNCT and SUNA are two different types of headaches that are characterized by brief one-sided head pain in the forehead, cheek, and/or chin on one side. The pain can often be triggered by touching the area and is usually accompanied by ipsilateral cranial autonomic features like a red eye, watery eye, droopy eyelid, runny nose, or nasal congestion. It has features similar to trigeminal neuralgia (a different type of pain), but SUNCT and SUNA have the changes on the face (like the red eye or runny nose) that are not present with trigeminal neuralgia. It is a rare headache and is also part of the trigeminal autonomic cephalalgia (TAC) group of headaches.
Preclinical research (non-human research)
To see our UT Health Houston Circadian Rhythms of Pain page, please click here »
- Leadership: Seung-Hee “Sally” Yoo
- Leadership: Mark J. Burish
- Collaborator: Zheng “Jake” Chen
- Team member: Chorong Han
- Team member: Hwayoung Baek
- Team member: Kaori Ono
UTHealth Houston Circadian Rhythms of Pain
Our biological clock controls the rhythm of many processes in our body including our 24-hour fluctuations in alertness, blood pressure, and many other physiological processes. Pain is one of the processes that has a 24-hour pattern. Some pain disorders are remarkably circadian such as cluster headache, where some patients will have cluster headaches every night at 2 AM for several weeks regardless of where they are in the world. We therefore are interested in how these circadian changes start at the molecular level and cause behavioral
Our research effort consists of a basic science laboratory and a clinical headache laboratory and uses the following techniques to study the circadian features of pain:
Research with humans (translational research)
- Whole genome sequencing
- RNA sequencing
Research with rodent and cell lines
- Animal pain models
- Circadian behavioral models
- RNA sequencing
- qPCR and ELISA
- Bioluminescence recordings
- Pharmacologic studies using human treatments
For more of our human clinical trials and epidemiology studies please see our Will Erwin Headache Research Center page.
To view our team’s publications, please click here »
The Will Erwin Headache Research Center is located at the Memorial Hermann Plaza Building at 6400 Fannin, Suite 2010, Houston TX. It is located within the Texas Medical Center (on the north side near the Houston Zoo and Hermann Park).
For more information: Please call the research office at (713) 486-7771 or email firstname.lastname@example.org.