Biography

Yuri Mackeyev received his Ph.D. from Moscow State University for the syntheses and study of properties of fluorinated [60]fullerenes. He worked as a high school teacher of chemistry beginning in 1985 and received six George Soros’s Open Society Foundation annual awards for teaching from 1996-2001.

In 2003, he joined Prof. L.J. Wilson’s lab at Rice University to carry out materials research on water-soluble [60]fullerene derivatives and functionalized carbon nanotubes used in potential health care applications.

Presently he is an Assistant Professor in Dr. Krishnan’s group at UTHealth Houston. His research interests lie in an interdisciplinary area between organic chemistry, chemistry of nanomaterials and clinical cancer research. These include a multibranch effort to define fundamental mechanisms and targets for cancer treatment with ionizing radiation and efficiently translate them to effective innovations for patients. This effort has resulted in more than 20 publications in the past ten years, mainly focused on medical application of nanomaterials, including gold (AuNPs), carbon nanotubes (SWCNTs), graphene nanoribbons (GNRs), [60]fullerene and fluorescently-tagged polymeric composites.

Education

PhD in Physical Chemistry
Lomonosov’s Moscow State University, Moscow, Russia

Areas of Interest

Research Interests

The primary focus of interest is applications of gold nanoparticles for tissue radiosensitization, imaging and image-guided cancer therapies. Another area is planning and conducting the synthesis of custom [60]fullerene conjugates with anticancer drugs will define better therapeutic targets on the molecular level within cancer cells, as well as the cancer tumor vasculature and its related supportive tissues.

Publications

  1. Gupta K, Jones JC, Farias VA, Mackeyev Y, Singh PK, Quiñones-Hinojosa A, Krishnan S. Identification of Synergistic Drug Combinations to Target KRAS-Driven Chemoradioresistant Cancers Utilizing Tumoroid Models of Colorectal Adenocarcinoma and Recurrent Glioblastoma. Front Oncol. 2022;12:840241. doi: 10.3389/fonc.2022.840241. eCollection 2022. PubMed PMID: 35664781; PubMed Central PMCID: PMC9158132.
  2. Shukla S, Fletcher S, Chauhan J, Chalfant V, Riveros C, Mackeyev Y, Singh PK, Krishnan S, Osumi T, Balaji KC. 3JC48-3 (methyl 4′-methyl-5-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)-[1,1′-biphenyl]-3-carboxylate): a novel MYC/MAX dimerization inhibitor reduces prostate cancer growth. Cancer Gene Ther. 2022 Apr 19;. doi: 10.1038/s41417-022-00455-4. [Epub ahead of print] PubMed PMID: 35440696.
  3. Bhattarai S, Mackeyev Y, Venkatesulu BP, Krishnan S, Singh PK. CXC chemokine receptor 4 (CXCR4) targeted gold nanoparticles potently enhance radiotherapy outcomes in breast cancer. Nanoscale. 2021 Nov 25;13(45):19056-19065. doi: 10.1039/d1nr05385j. PubMed PMID: 34757363; PubMed Central PMCID: PMC9124374.
  4. Wang J, Salzillo T, Jiang Y, Mackeyev Y, David Fuller C, Chung C, Choi S, Hughes N, Ding Y, Yang J, Vedam S, Krishnan S. Stability of MRI contrast agents in high-energy radiation of a 1.5T MR-Linac. Radiother Oncol. 2021 Aug;161:55-64. doi: 10.1016/j.radonc.2021.05.023. Epub 2021 Jun 3. PubMed PMID: 34089753; PubMed Central PMCID: PMC8324543.
  5. Kim JB, Mackeyev Y, Raghuram S, Cho SH, Krishnan S. Synthesis and characterization of gadolinium-decorated [60]fullerene for tumor imaging and radiation sensitization. Int J Radiat Biol. 2021;97(8):1129-1139. doi: 10.1080/09553002.2021.1872814. Epub 2021 Jan 21. PubMed PMID: 33428854.
  6. Singh A, Kim BK, Mackeyev Y, Rohani P, Mahajan SD, Swihart MT, Krishnan S, Prasad PN. Boron-Nanoparticle-Loaded Folic-Acid-Functionalized Liposomes to Achieve Optimum Boron Concentration for Boron Neutron Capture Therapy of Cancer. J Biomed Nanotechnol. 2019 Aug 1;15(8):1714-1723. doi: 10.1166/jbn.2019.2800. PubMed PMID: 31219010.
  7. Yang X, Venkatesulu BP, Mahadevan LS, Aliru ML, Mackeyev Y, Singh A, Prasad PN, Krishnan S. Gold-Small Interfering RNA as Optically Responsive Nanostructures for Cancer Theranostics. J Biomed Nanotechnol. 2018 May 1;14(5):809-828. doi: 10.1166/jbn.2018.2536. Review. PubMed PMID: 29883555.
  8. Lapin NA, Vergara LA, Mackeyev Y, Newton JM, Dilliard SA, Wilson LJ, Curley SA, Serda RE. Biotransport kinetics and intratumoral biodistribution of malonodiserinolamide-derivatized [60]fullerene in a murine model of breast adenocarcinoma. Int J Nanomedicine. 2017;12:8289-8307. doi: 10.2147/IJN.S138641. eCollection 2017. PubMed PMID: 29180866; PubMed Central PMCID: PMC5695510.
  9. Lapin NA, Krzykawska-Serda M, Dilliard S, Mackeyev Y, Serda M, Wilson LJ, Curley SA, Corr SJ. The effects of non-invasive radiofrequency electric field hyperthermia on biotransport and biodistribution of fluorescent [60]fullerene derivative in a murine orthotopic model of breast adenocarcinoma. J Control Release. 2017 Aug 28;260:92-99. doi: 10.1016/j.jconrel.2017.05.022. Epub 2017 May 17. PubMed PMID: 28527736; PubMed Central PMCID: PMC5549922.
  10. Mackeyev Y, Mark C, Kumar N, Serda RE. The influence of cell and nanoparticle properties on heating and cell death in a radiofrequency field. Acta Biomater. 2017 Apr 15;53:619-630. doi: 10.1016/j.actbio.2017.02.003. Epub 2017 Feb 5. PubMed PMID: 28179157; PubMed Central PMCID: PMC6238638.
  11. Chen HJ, Wei Z, Sun J, Bhattacharya A, Savage DJ, Serda R, Mackeyev Y, Curley SA, Bu P, Wang L, Chen S, Cohen-Gould L, Huang E, Shen X, Lipkin SM, Copeland NG, Jenkins NA, Shuler ML. A recellularized human colon model identifies cancer driver genes. Nat Biotechnol. 2016 Aug;34(8):845-51. doi: 10.1038/nbt.3586. Epub 2016 Jul 11. PubMed PMID: 27398792; PubMed Central PMCID: PMC4980997.
  12. Yoo H, Yan S, Ra J, Jeon D, Goh B, Kim T, Mackeyev Y, Ahn Y, Kim H, Wilson L. Tin porphyrin immobilization significantly enhances visible-light-photosensitized degradation of Microcystins: Mechanistic implications. Applied Catalysis B: Environmental. 2016; 199:33-44.
  13. Gizzatov A, Hernández-Rivera M, Keshishian V, Mackeyev Y, Law JJ, Guven A, Sethi R, Qu F, Muthupillai R, Cabreira-Hansen Mda G, Willerson JT, Perin EC, Ma Q, Bryant RG, Wilson LJ. Surfactant-free Gd3+-ion-containing carbon nanotube MRI contrast agents for stem cell labeling. Nanoscale. 2015 Jul 28;7(28):12085-91. doi: 10.1039/c5nr02078f. Epub 2015 Jun 29. PubMed PMID: 26119138.
  14. Choi Y, Ye Y, Mackeyev Y, Cho M, Lee S, Wilson LJ, Lee J, Alvarez PJ, Choi W, Lee J. C60 aminofullerene-magnetite nanocomposite designed for efficient visible light photocatalysis and magnetic recovery. Carbon. 2014; 69:92.
  15. Brame J, Fattori V, Clarke R, Mackeyev Y, Wilson LJ, Li Q, Alvarez P. Water Disinfection Using Nanotechnology for Safer Irrigation: A Demonstration Project in Swaziland. Environmental Engineer and Scientist: Applied Research & Practice. 2014; 50(2):40-46.
  16. Mackeyev Y, Raoof M, Cisneros B, Koshkina N, Berger CS, Wilson LJ, Curley SA. Toward Paclitaxel-[60]Fullerene Immunoconjugates as a Targeted Prodrug against Cancer. Nanosystems: Physics, Chemistry, Mathematics. 2014; 5(1):67-75.
  17. Huang F, Mackeyev Y, Watson E, Cheney MA, Wilson LJ, Suh J. Evidence for nuclear internalization of biocompatible [60]fullerene. The European Journal of Nanomedicine. 2013; 5(1):51–55. doi: 10.1515/ejnm-2012-0009.
  18. Sethi R, Mackeyev Y, Wilson LJ. The Gadonanotubes revisited: A new frontier in MRI contrast agent design. Inorganica Chimica Acta. 2012 December; 393:165–172. doi: 10.1016/j.ica.2012.07.004.
  19. Corr SJ, Raoof M, Mackeyev Y, Phounsavath S, Cheney MA, Cisneros BT, Shur M, Gozin M, McNally PJ, Wilson LJ, Curley SA. Citrate-capped gold nanoparticle electrophoretic heat production in response to a time-varying radiofrequency electric-field. J Phys Chem C Nanomater Interfaces. 2012 Nov 15;116(45):24380-24389. doi: 10.1021/jp309053z. PubMed PMID: 23795228; PubMed Central PMCID: PMC3686525.
  20. Kim H, Kim W, Mackeyev Y, Lee GS, Kim HJ, Tachikawa T, Hong S, Lee S, Kim J, Wilson LJ, Majima T, Alvarez PJ, Choi W, Lee J. Selective oxidative degradation of organic pollutants by singlet oxygen-mediated photosensitization: tin porphyrin versus C60 aminofullerene systems. Environ Sci Technol. 2012 Sep 4;46(17):9606-13. doi: 10.1021/es301775k. Epub 2012 Aug 14. PubMed PMID: 22852818.
  21. Gizzatov A, Dimiev A, Mackeyev Y, Tour JM, Wilson LJ. Highly water soluble multi-layer graphene nanoribbons and related honey-comb carbon nanostructures. Chem Commun (Camb). 2012 Jun 7;48(45):5602-4. doi: 10.1039/c2cc31407j. Epub 2012 May 1. PubMed PMID: 22546893.
  22. Raoof M, Mackeyev Y, Cheney MA, Wilson LJ, Curley SA. Internalization of C60 fullerenes into cancer cells with accumulation in the nucleus via the nuclear pore complex. Biomaterials. 2012 Apr;33(10):2952-60. doi: 10.1016/j.biomaterials.2011.12.043. Epub 2012 Jan 14. PubMed PMID: 22245558; PubMed Central PMCID: PMC3268891.
  23. Grattoni A, Fine D, Zabre E, Ziemys A, Gill J, Mackeyev Y, Cheney MA, Danila DC, Hosali S, Wilson LJ, Hussain F, Ferrari M. Gated and near-surface diffusion of charged fullerenes in nanochannels. ACS Nano. 2011 Dec 27;5(12):9382-91. doi: 10.1021/nn2037863. Epub 2011 Nov 14. PubMed PMID: 22032773.
  24. Lee J, Hong S, Mackeyev Y, Lee C, Chung E, Wilson LJ, Kim JH, Alvarez PJ. Photosensitized oxidation of emerging organic pollutants by tetrakis C₆₀ aminofullerene-derivatized silica under visible light irradiation. Environ Sci Technol. 2011 Dec 15;45(24):10598-604. doi: 10.1021/es2029944. Epub 2011 Nov 17. PubMed PMID: 22054355.
  25. Lee J, Mackeyev Y, Cho M, Wilson LJ, Kim JH, Alvarez PJ. C60 aminofullerene immobilized on silica as a visible-light-activated photocatalyst. Environ Sci Technol. 2010 Dec 15;44(24):9488-95. doi: 10.1021/es1028475. Epub 2010 Nov 15. PubMed PMID: 21077614.
  26. Cho M, Lee J, Mackeyev Y, Wilson LJ, Alvarez PJ, Hughes JB, Kim JH. Visible light sensitized inactivation of MS-2 bacteriophage by a cationic amine-functionalized C60 derivative. Environ Sci Technol. 2010 Sep 1;44(17):6685-91. doi: 10.1021/es1014967. PubMed PMID: 20687548.
  27. Hassan AA, Chan BT, Tran LA, Hartman KB, Ananta JS, Mackeyev Y, Hu L, Pautler RG, Wilson LJ, Lee AV. Serine-derivatized gadonanotubes as magnetic nanoprobes for intracellular labeling. Contrast Media Mol Imaging. 2010 Jan-Feb;5(1):34-8. doi: 10.1002/cmmi.293. PubMed PMID: 20101755.
  28. Lee I, Mackeyev Y, Cho M, Li D, Kim JH, Wilson LJ, Alvarez PJ. Photochemical and antimicrobial properties of novel C60 derivatives in aqueous systems. Environ Sci Technol. 2009 Sep 1;43(17):6604-10. doi: 10.1021/es901501k. PubMed PMID: 19764224.
  29. Mackeyev Y, Hartman KB, Ananta JS, Lee AV, Wilson LJ. Catalytic synthesis of amino acid and peptide derivatized gadonanotubes. J Am Chem Soc. 2009 Jun 24;131(24):8342-3. doi: 10.1021/ja900918x. PubMed PMID: 19492838; PubMed Central PMCID: PMC2720026.
  30. Ashcroft JM, Hartman KB, Kissell KR, Mackeyev Y, Pheasant S, Young S, Van der Heide PA, Mikos AG, Wilson LJ. Single-Molecule I2@US-Tube Nanocapsules: A New X Ray Contrast-Agent Design. Advanced Materials. 2007; 19(5):573–576.
  31. Mackeyev Y, Bachilo S, Hartman KB, Wilson LJ. The purification of HiPco SWCNTs with liquid bromine at room temperature. Carbon. 2007; 45:1013-1017. doi: 10.1016/j.carbon.2006.12.026.
  32. Ashcroft JM, Hartman KB, Mackeyev Y, Hofmann C, Pheasant S, Alemany L, Wilson LJ. Functionalization of individual ultra-short single-walled carbon nanotubes. Nanotechnology. 2006; 17:5033-5037. doi: 10.1002/adma.200601424.
  33. Mackeyev YA, Marks JW, Rosenblum MG, Wilson LJ. Stable containment of radionuclides on the nanoscale by cut single-wall carbon nanotubes. J Phys Chem B. 2005 Mar 31;109(12):5482-4. doi: 10.1021/jp0456436. PubMed PMID: 16851586.
  34. Makeev Y, Troshin P, Boltalina O, Kirikova M, Chelovskaya N. A study of C60F48 solvates with alkanes by differential scanning calorimetry. Physics of the Solid State. 2002; 44(3):536-538. doi: 10.1134/1.1462699.
  35. Denisenko N, Boltalina O, Troshin P, Mackeyev Y, Serov M, Chelovskaya N. Synthesis and thermal stability of C60Br8. Fullerenes. 2001; 11:277-279.
  36. Troshin P, Boltalina O, Mackeyev Y, Chelovskaya N, Neretin I. Isolation and Characterisation of the C60F48 Complexes with Some Aromatic Hydrocarbons. Fullerenes. 2001; 11:530-547.
  37. Troshin P, Prisyazhnuk V, Troyanov S, Boltalina O, Mackeyev Y, Kyrikova M. Molecular Complexes of C70 with Arenes: DSC and X-Ray Diffraction Studies. Fullerenes. 2001; 11:548-558.
  38. Troshin P, Mackeyev Y, Boltalina O, Chelovskaya N. Charge Transfer Complexes of C60F48 with Aromatic Hydrocarbons. Fullerenes 2000: chemistry and physics of fullerenes and carbon nanomaterials. 2000; 12:159-165.
  39. Troshin P, Mackeyev Y, Chelovskaya N, Slovokhotov Y, Boltalina O, Sidorov L. Solvates of the fluorofullerenes C60F46 and C60F48 with aliphatic hydrocarbons. FULLERENE SCIENCE AND TECHNOLOGY. 2000; 8(6):501-517. doi: 10.1080/10641220009351430.
  40. Sidorov L, Mackeyev Y. The Fullerene Chemistry. Soros Educational Journal. 2000; 5:21-25.
  41. Troshin P, Makeev Y, Chelovskaya N, Slovokhotov Y, Boltalina O, Sidorov L. DSC and X-Ray Diffraction Study of the Fluorofullerene Solvates. Recent Advances in the Chemistry and Physics of Fullerenes and Related Materials. 1999; 12:516-530.