Biography

The major focus of Dr. Kramer’s work is development of cardiovascular MRI techniques, MRI of head trauma, MRI of the intracranial abnormalities of spina bifida, development of fast body MRI techniques, and the master teaching program: development of novel methods to teach gross anatomy.

 

Certification

American Board of Radiology, Diagnostic Radiology, 1989

Education

Medical School
University of Illinois Medical School, Chicago, IL, 1985
Residency
Diagnostic Radiology, University of Illinois Hospital, Chicago, IL, 1989
Fellowship
Magnetic Resonance Imaging, University of Illinois Hospital, Chicago, IL, 1990

Research Information

**Faculty profiles will only highlight current information (the last three years). Please see the faculty’s CV for more information.

 

CURRENT GRANT SUPPORT:

Ocular Health MRI Data, Larry A. Kramer, M. D, Wyle Laboratories, 12/18/2015-9/30/2018, $85,025.00

Space CENT, Eric Bershad, Larry Kramer, M.D., Baylor College of Medicine, 10/1/17-01/08/2019, $25,000.00

 

Publications

Publication Information

**Faculty profiles will only highlight current information (the last three years). Please see the faculty’s CV for more information.

 

Abstracts

  1. Kramer, L, Cerebrovascular and Intracranial Effects of 12 degree  Head-Down Tilt and Hypercapnia: A Preliminary Study using Phase-contrast, Volumetric and Diffusion Tensor MR Imaging. 16th International Symposium on Intracranial Pressure and Neuromonitoring in Cambridge, MA from June 28 – July 2, 2016.
  2. Rabiei P, Behzad B, Hasan K, Kamali A, Kramer L, Riascos R. Pre- and Post-Flight Size Comparison of the Major Dural Venous Sinuses in Astronauts. Accepted for oral presentation at 2018 NASA Human Research Program Investigators’ Workshop / Galveston Island Convention Center, Galveston, TX January 22-24, 2018,Submitted to 2018 ASNR (Scientific Abstract)
  3. Riascos R, Hasan K, Kamali A, Mwangi B, Hakimelahi R, Rabiei P, Sargsyan A, Kramer L. Longitudinal Analysis of Quantitative Brain MRI in Astronauts Following Microgravity Exposure. 2017. Accepted for oral presentation at 2018 NASA Human Research Program Investigators’ Workshop / Galveston Island Convention Center, Galveston, TX January 22-24, 2018,Submitted to 2018 ASNR (Scientific Abstract)
  4. Zaza R, Hakimelahi R, Rabiei P, Kamali A, Hasan K, Kramer L, Riascos R. Comparison of the use of volumetry vs linear height measurements to detect changes in the pituitary gland using 3D-T1W non-contrast MRI. Accepted for oral presentation at 2018 NASA Human Research Program Investigators’ Workshop Galveston Island Convention Center, Galveston, TX, January 22-24, 2018
  5. Zaza R, Hakimelahi R, Rabiei P, Kamali A, Hasan K, Kramer L, Riascos R. Comparison of the pituitary gland volume pre- and post-flight in astronauts. Accepted for oral presentation at 2018 NASA Human Research Program Investigators’ Workshop Galveston Island Convention Center, Galveston, TX, January 22-24, 2018
  6. L.A. Kramer, M.I. Hirzallah, K.M. Hasan, K. Younes, U. Menon, B. Macias, M. Stenger and P. Narayana,UTHSC-Houston, UPMC, KBRwyle and NASA Johnson Space Center, quantitative magnetic resonance of cerebral blood flow hemodynamics in acute head down tilt, Galveston Island Convention Center, Galveston, TX, January 22-24, 2018
  7. Younes K,  Hasan KM,  Mcgough CE, Kamali A, Keser Z, Melicher T, Kramer LA, Schulz PE. Quantitative diffusion tensor tractography of the superior thalamic radiation and the corticospinal tract in relation to ventricular and sulcal CSF Volumes in patients with ventriculomegaly diagnosed with normal pressure hydrocephalus.  American Academy of Neurology 70th Annual Meeting, April 21-27, 2018, Los Angeles, CA.

Refereed Original Articles in Journals:

  1. Kramer LAHasan KMSargsyan AEMarshall-Goebel K,, Rittweger JDonoviel DHigashi S8, Mwangi BGerlach DABershad EMSPACECOT Investigators Group.”Quantitative MRI volumetry, diffusivity, cerebrovascular flow and cranial hydrodynamics during head down tilt and hypercapnia: the SPACECOT study, J Appl Physiol (1985).2017 May 1;122(5):1155-1166. doi: 10.1152/japplphysiol.00887.2016. Epub 2017 Feb 16. PMID: 28209740
  2. Gerlach DA1, Marshall-Goebel K, Hasan KM, Kramer LA, Alperin N, Rittweger J1, MRI-derived diffusion parameters in the human optic nerve and its surrounding sheath during head-down tilt, NPJ Microgravity. 2017 Jun 21;3:18. doi: 10.1038/s41526-017-0023-y. eCollection 2017, PMID 28649640
  3. Hasan KM, Mwangi B, Keser Z, Roy Riascos. Sargsyan AE.  Kramer LA.
    Brain Quantitative MRI Metrics in Astronauts as a Unique Professional Group. Journal of Neuroimaging 2018 2018;00:1-13,DOI: 10.1111/jon.12501
  4. Ewing-Cobbs L, DeMaster DM, Watson CG, Prasad MR, Cox CS, Kramer LA, et al. Post-traumatic Stress Symptoms after Pediatric Injury: Relation to Prefrontal-Limbic Circuitry. J Neurotrauma. 2019. PMID: 30672379
  5. Younes K, Hasan KM, Kamali A, McGough CE, Keser Z, Hasan O,  Melicher T, Kramer LA, Schulz PE, the Alzheimer’s Disease Neuroimaging Initiative Researchers. Diffusion Tensor Imaging of the Superior Thalamic Radiation and Cerebrospinal Fluid Distribution in Idiopathic Normal Pressure Hydrocephalus. J of Neuroimaging 2019 (in press).
  6. Riascos RF, Kamali A, Hakimelahi R, Mwangi B, Rabiei P, Seidler RD, Behzad BB, Keser Z, Kramer LA, Hasan KM. Longitudinal Analysis of Quantitative Brain MRI in Astronauts Following Microgravity Exposure. J Neuroimaging 2019; 29:323-330.
  7. “Intracranial Effects of Microgravity: A Prospective Longitudinal MRI Study,”(in press)

 

Chapters

  1. Kramer LA. Eye, Orbit and Pituitary MRI:Relevance to Space Medicine. Chapter 3.  Macias BR, Liu JHK, Otto C, Hargens AR. Intracranial pressure and its effect on vision in space and on earth: vision impairment in space. New Jersey: World Scientific; 2017. ISBN-13: 978-9814667104, ISBN-10: 9814667102

 

Other Professional Communications

Oral Presentations

  1. L Kramer Cerebrovascular and Intracranial Effects of 12 degree Head-Down Tilt and Hypercapnia: A Preliminary Study using Phase-contrast and Volumetric MR Imaging, 2017 NASA Human Research Program Houston Texas, January 23-25, 2017

 

Scientific Exhibits

  1. L Kramer Spaceflight-Associated Neuro-Ocular Syndrome: The Role of Cerebral Spinal Fluid Physiology, Microgravity Analogues and Quantitative Magnetic Resonance Imaging (Qmri), ASNR 56th Annual Meeting, June 4-7, 2018 in Vancouver, BC, Canada.
  2. Bershad E. Venkatasubba Rao C. Marshall-Goebel K. Damani R. Cohen H. Clark J. Sangi-Haghpeykar H. Strangman G. Kramer L. Hasan K. Stern C. Rittweger J. Space-cent: studying the physiological and anatomical effects of centrifugation and head down tilt [#19285]. This study will assess the cerebral and ocular effects of 60 days of bedrest combined with an artificial gravity countermeasure, 2019 NASA HRP IWS Galveston, Texas January 22-25, 2019
  3. Macias B. Otto C Ploutz-Snyder R, Sargsyan A. Alexander D. Kramer L. Riascos R. Samuels B. Gibson B, Patel N Lee S,  Laurie S. Stenger M,. Prospective observational study of ocular health in iss astronauts – the ocular health study [#19308]. The purpose of this study is to characterize and quantify the ocular, neurological, and cardiovascular variables associated with the development of sans before, during, and after long-duration ISS missions. 2019 NASA HRP IWS Galveston, Texas January 22-25, 2019
  4. Kramer L, Hasan k. Stenger m. Sargsyan a. Riascos r. Ploutz-synder r. Macias b. Microgravity-induced changes in pituitary morphology, brain volumetry, and cerebral spinal fluid hydrodynamics: relationship to spaceflight associated neuro-ocular syndrome [#19122]. Long duration microgravity exposure deforms the pituitary gland similar to that found with idiopathic intracranial hypertension supporting the hypothesis that microgravity increases intracranial pressure. 2019 NASA HRP IWS Galveston, Texas January 22-25, 2019

 

 

 

 

 

Honors and Awards

**Faculty profiles will only highlight current information (the last three years). Please see the faculty’s CV for more information.

 

  • Distinguished Physician, Memorial Hermann-TMC/Children’s 2018
  • Fellow, American College of Radiology (FACR), 2019