Dr. Park received his Ph.D. in Neuroscience at Kyung Hee University, South Korea, in the Lab of Dr. Byung Kwan Jin, Ph.D. in 2013. His graduate work mainly focused on developing the therapeutic strategies for Parkinson’s disease (PD) by regulating transient receptor potential vanilloid 1 (TRPV1, pain receptor) in microglia/ astrocytes, and for Alzheimer’s disease (AD) by inhibiting neuroinflammation.

His initial postdoctoral training achieved in the Lab of Dr. M. Maral Mouradian, M.D. at Rutgers University. He focused on elucidating the mechanisms of α-synuclein propagation and on developing the therapeutic strategy for α-synuclein-mediated neurotoxicity in PD. To develop the innovative therapeutic strategy for levodopa-induced dyskinesia (LID) in PD patients, he examined effective medical management of LID by modulation of the dual κ-agonist/μ-antagonist opioid receptor in macaque monkey PD model.

Afterward, he received training in the Lab of Dr. E. Richard Stanley, Ph.D. at Albert Einstein College of medicine. He studied the role of microglial colony-stimulating factor 1 receptor (CSF-1R) and its ligands in brain development and adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) which is CSF1R-deficiency dementia.

In 2018, he joined the Department of Neurosurgery, in the lab of Dr. Peng R. Chen, M.D. and Dr. Eunhee Kim, Ph.D. to uncover the underlying pathology of brain arteriovenous malformation (bAVM) and intracerebral hemorrhage (ICH). He contributed to establishing the novel mouse model of bAVM/ICH, and trying to develop the therapeutic strategy for the bAVM and preventive strategy for the ICH.

In 2022, he was promoted to tenure-track assistant professor in the Vivian L. Smith Department of Neurosurgery. In addition, he is running the Glia Biology Laboratory to investigate glia’s role in the microvascular side of neurological disease, including bAVM, PD, AD, and aging.

Dr. Park’s work contributed to publishing in several scientific articles, including Annals of Neurology, Brain, Cell reports, Acta Neuropathologica, Proceedings of the National Academy of Sciences, Neurobiology of Aging, Brain Research Bulletin, and Antioxidants & Redox Signaling.


Graduate School
Kyung Hee University, Seoul, South Korea
Postdoctoral Fellowship
Rutgers University, Piscataway, New Jersey
Postdoctoral Fellowship
Albert Einstein College of Medicine, Bronx, New York

Areas of Interest

Research Interests

My research focuses on understanding the pathology of brain arteriovenous malformation (bAVM) and bAVM-induced spontaneous intracerebral hemorrhage (ICH). Using our novel mouse model, we focus on uncovering the pathology of bAVM genesis during development and aging by dissecting the role of microglia/macrophages, astrocytes, and endothelial cells in the cerebrovasculature. We are also interested in exploring the underlying function of glia in the microvascular side of neurological diseases, including Parkinson’s disease, Alzheimer’s disease, and aging. We are dissecting the multicellular neurovascular unit that includes neurons, astrocytes, microglia, and cells related to blood vessel formation.


  1. Eun S. Park*, Sehee Kim, Derek C. Yao, Jude P.J. Savarraj, Huimahn Alex Choi, Peng Roc Chen, Eunhee Kim*. Soluble endoglin stimulates inflammatory and angiogenic responses in microglia that are associated with endothelial dysfunction. Int J Mol Sci. 22;23(3):1225. 2022. (*Co-corresponding author)
  2. Jude Savarraj, Eun S. Park, Gabriela Copo Delevati, Sarah Hinds, Diego Morales, Hilda Ahnstedt, Atzhiry Paz, Andres Assing, Fudong Liu, Shivanki Juneja, Eunhee Kim, Sung-min Cho, Aaron Gusdon, Pramod Dash, Louise D McCullough, H Alex Choi. Brain injury, endothelial injury and inflammatory markers are elevated and express sex specific alterations after COVID-19. J Neuroinflammation. 27;18(1):277. 2021.
  3. Annals of Neurology CoverEun S. Park, Sehee Kim, Shuning Huang, Ji Young Yoo, Jakob Korbelin, Tae Jin Lee, Balveen Kaur, Pramod K. Dash, Peng Roc Chen, Eunhee Kim. Selective endothelial hyperactivation of oncogenic KRAS induces brain arte-riovenous malformations. Ann Neurol. 89(5):926-941. 2021.
  4. Margaret Yeh, Yin-Ying Wang, Ji Young Yoo, Christina Oh, Yoshihiro Otani, Jin Muk Kang, Eun S. Park, Eunhee Kim, Sangwoon Chung, Young-Jun Jeon, George A Calin, Balveen Kaur, Zhongming Zhao, Tae Jin Lee. MicroRNA-138 suppresses glioblastoma proliferation through downregulation of CD44. Sci Rep. 28;11(1):9219. 2021
  5. Fabrizio Biundo, Violeta Chitu, Gabriel G. L. Shlager, Eun S. Park, Maria E. Gulinello, Kusumika Saha, Harmony C. Ketchum, Christopher Fernandes, Şolen Gökhan, Mark F. Mehler and E. Richard Stanley. Microglial reduction of colony stimulating factor-1 receptor expression is sufficient to confer adult onset leukodystrophy. Glia. 69(3):779-791. 2021.
  6. Violeta Chitu, Fabrizio Biundo, Gabriel G. Shlager, Eun S. Park, Ping Wang, Deyou Zheng, Maria Gulinello, Solen Gokhan, Harmony Ketchum, Kusumika Saha, Mark F. Mehler and E. R. Stanley. Microglial homeostasis requires balanced CSF-1/CSF-2 receptor signaling. Cell Rep. 3;30(9):3004-3019. 2020.
  7. Jie Zhang*, Eun S. Park*, Hye-Jin Park, Run Yan, Magda Grudniewska, Stephanie Oh, M. Maral Mouradian. Apoptosis signal regulating kinase 1 deletion mitigates α-synuclein pre-formed fibril propagation in mice. Neurobiol Aging. 85:49-57. 2020. (*Co-first author)
  8. Goichi Beck*, Arun Singh*, Jie Zhang*, Lisa F. Potts, Jong-Min Woo, Eun S. Park, M. Maral Mouradian, and Stella M. Papa. Role of striatal ΔFosB in L-Dopa-induced dyskinesias of parkinsonian non-human primates. Proc Natl Acad Sci U S A. 10;116(37):18664-18672. 2019.
  9. Kyung I. Kim*, Jeong Y. Baek*, Jae Y. Jeong*, Jin H. Nam, Eun S. Park, Eugene Bok, Won-Ho Shin, Young Cheul Chung and Byung K. Jin. Delayed treatment of capsaicin produces partial motor recovery by enhancing dopamine function in MPP+-lesioned rats via ciliary neurotrophic factor. Exp Neurobiol. 28(2):289-299. 2019.
  10. Run Yan, Jie Zhang, Hye-Jin Park, Eun S. Park, Stephanie Oh, Haiyan Zheng, Eunsung Junn, Michael Voronkov, Jeffry B. Stock, M. Maral Mouradian. Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in mouse models of Parkinson’s disease and Dementia with Lewy Bodies. Proc Natl Acad Sci U S A. 18;115(51):E12053-E12062. 2018.
  11. Nora Hagemeyer, Klara-Maria Hanft, Maria-Anna Akriditou, Nicole Unger, Eun S. Park, Richard Stanley, Ori Staszewski, Leda Dimou & Marco Prinz. Microglia contribute to normal myelinogenesis and to oligodendrocyte progenitor maintenance during adulthood. Acta Neuropathol. 134(3):441-458. 2017.
  12. Hye-Jin Park*, Kang-Woo Lee*, Eun S. Park, Stephanie Oh, Run Yan, Jie Zhang, Michael Voronkov, Steven P. Braithwaite, Jeffry B. Stock, M. Maral Mouradian. Dysregulation of Protein Phosphatase 2A in Parkinson Disease and Dementia with Lewy Bodies. Ann Clin Transl Neurol. 7;3(10):769-780. 2016.
  13. Ga Ram Jeong, Sun-kyoung Im, Yun-Hee Bae, Eun S. Park, Byung Kwna Jin, Hyug Moo Kwon, Beom-Joon Lee, Youngmin Bu, Eun-Mi Hur, Byoung Dae Lee. Inflammatory signals induce the expression of tonicity-responsive enhancer binding protein (TonEBP) in microglia. J Neuroimmunol. 15;295-296:21-29. 2016.
  14. Lisa F. Potts*, Eun S. Park*, Jong-Min Woo, Bhagya L. Dyavar Shetty, Arun Singh, Steven P. Braithwaite, Michael Voronkov, Stella M. Papa, M. Maral Mouradian. Dual k-agonist/ m-antagonist opioid receptor modulation reduces L-dopa induced dyskinesia and corrects dysregulated striatal changes in the non-human primate model of Parkinson’s disease. Ann Neurol. 77(6):930-941. 2015. (*Co-first author)
  15. Jin H. Nam*, Eun S. Park*, So-Yoon Won*, Kyoung I. Kim*, Jaeyeong Jeong*, Jeong Y. Baek*, Yu A. Lee*, Eun J. Cho, Minyoung Jin, Young C. Chung, Byoung D. Lee, Sung Hyun Kim, Eung-Gook Kim, Kyunghee Byun, Bonghee Lee, Dong Ho Woo, C. Justin Lee, Sang R. Kim, Eugene Bok, Yoon-Seong Kim, Tae-Beom Ahn, Hyuk Wan Ko, Saurav Brahmachari, Olga Pletinkova, Juan C. Troconso, Valina L. Dawson, Ted M. Dawson, and Byung K. Jin. TRPV1 on astrocytes rescues nigral dopamine neurons in the Parkinson’s disease via CNTF. 138(12):3610-3622. 2015. (*Co-first author)
  16. Kang-Woo Lee, Jong-Min Woo, Joo-Young Im, Eun S. Park, Liqiang He, Hidenori Ichijo, Eunsung Junn, M. Maral Mouradian. Apoptosis signal-regulating kinase 1 modulates the phenotype of a-synuclein transgenic mice. Neurobiol Aging. 36(1):519-526. 2015.
  17. Eun S. Park, Sang R. Kim, Byung K. Jin. Transient receptor potential vanilloid subtype 1 contributes to mesencephalic dopaminergic neuronal survival by inhibiting microglia-originated oxidative stress. Brain Res Bull. 1;89(3-4):92-96. 2012.
  18. Jin H. Nam*, Keun W. Park*, Eun S. Park*, Yong B. Lee, Han G. Lee, Hyung-Hwan Baik, Yoon-Seong Kim, Maeng, J. Park, Byung K. Jin. Interleukin-13/-4-induced oxidative stress contributes to death of hippocampal neurons in Aβ1-42-treated hippocampus in vivo. Antioxid Redox Signal. 15;16(12):1369-1383. 2012. (*Co-first author)
  19. Young C. Chung, Sang R. Kim, Ju-Young Park, Eun S. Chung, Keun W. Park, So Y. Won, Eugene Bok, Minyoung Jin, Eun S. Park, Sung-Hwa Yoon, Hyuk W. Ko, Yoon-Seong Kim, Byung K. Jin. Fluoxetine prevents MPTP-induced loss of dopaminergic neurons by inhibiting microglial activation. Neuropharmacology. 60(6):963-974. 2011.
  20. Changhwan Jang, Jin-Kyu Choi, EunYoung Kim, Eun-Su Park, Wilma Wasco, Joseph D. Buxbaum, Yong-Sun Kim, Eun-Kyoung Choi. Calsenilin is degraded by the ubiquitin–proteasome pathway. Biochem Biophys Res Commun. 11;405(2):180-185. 2011.
  21. Eun S. Chung, Young C. Chung, Eugene Bok, Hyung H. Baik, Eun S. Park, Ju-Young Park, Sung-Hwa Yoon, Byung K. Jin. Fluoxetine prevents LPS-induced degeneration of nigral dopaminergic neurons by inhibiting microglia-mediated oxidative stress. Brain res. 2;1363:143-150. 2010.
  22. Young C. Chung, Hyuk Wan Ko, Eugene Bok, Eun S. Park, Sue Hee Huh, Jin H. Nam, Byung K. Jin. The role of neuroinflammation on the pathogenesis of Parkinson’s disease. BMB Rep. 43(4):225-232. 2010.
  23. Sang R. Kim, Young C. Chung, Eun S. Chung, Keun W. Park, So-Yoon Won, Eugene Bok, Eun S. Park, Byung k. Jin. Roles of Transient Receptor Potential Vanilloid Subtype 1 and Cannabinoid Type 1 Receptors in the Brain: Neuroprotection versus Neurotoxicity Mol Neurobiol. 35(3):245-254. 2007.