Biography

Dr. McBride received his Ph.D. from the University of California Riverside under the mentorship of Dr. Victor G. J. Rodgers where his research focused on understanding the phenomena of crowded protein osmotic pressure and its applications to medical devices. During his Ph.D., he received a number of Fellowships, including an NSF IGERT Fellowship in Video Bioinformatics and a DOE GAANN Fellowship.

His postdoctoral training occurred under the tutelage of Dr. John H. Zhang at Loma Linda University where he studied translational neuroscience research with an emphasis on cerebrovascular disease. During his postdoctoral work, Dr. McBride received an NIH F32 award from NHLBI to develop and study an animal model of vasovagal syncope. He has also co-authored several papers in the fields of engineering and neuroscience. In 2017, Dr. McBride joined the Vivian L. Smith Department of Neurosurgery as an Assistant Professor.

Education

Graduate School
Doctorate of Philosophy in Bioengineering, University of California, Riverside, CA

Areas of Interest

Research Interests

Neurological Diseases with an Emphasis on Stroke; Thermodynamics and Transport Phenomena of Crowded Protein Solutions; Bioreactions; Video Bioinformatics, Video Microscopy, and Live Imaging; Medical Imaging and Its Applications for Studying Disease and Mechanisms; Device Design with an Emphasis on Medical Devices

The research in Dr. McBride’s lab is focused on understanding the pathophysiology of subarachnoid hemorrhage (SAH), particularly focusing on delayed cerebral ischemia (DCI). Delayed cerebral ischemia after SAH is a critical factor in the poor prognosis of surviving patients, and currently we still do not fully understand the mechanisms causing DCI. We are using live imaging to understand the cerebrovascular dynamics as they are related to ensuing injury subsequent to SAH. Additionally, we are identifying novel therapeutic targets and developing strategies aimed at attenuating DCI following SAH.

Dr. McBride is collaborating with Dr. Spiros Blackburn to investigate the role of haptoglobin phenotype in DCI post-SAH. The goal of this work is to identify patients who would be at high risk for developing DCI and poor outcome after SAH. This work will also elucidate novel therapeutic targets for preventing DCI.

Publications

Articles
1. McBride DW, Reis C, Frank E, Klebe DW, Zhang JH, Applegate II R, Tang J, “An Experimental Model of Vasovagal Syncope Induces Cerebral Hypoperfusion and Fainting-like Behavior in Awake Rats” PlosOne, accepted
2. Enkhjargal B, McBride DW, Manaenko A, Sakai Y, Tang J, Zhang JH, “Intranasal Administration of Vitamin D Attenuates Blood-Brain Barrier Disruption through Endogenous Upregulation of OPN and Activation of CD44/P-gp Glycosylation Signaling after Subarachnoid Hemorrhage in Rats,” JCBFM, accepted
3. Lekic T, Klebe DW, Pichon P, Brandkov K, Sultan S, McBride DW, Casel D, Al-Bayati A, Ding Y, Tang J, Zhang JH, “Aligning Animal Models of Clinical Germinal Matrix Hemorrhage, from Basic Correlation to Therapeutic Approach,” Curr Drug Targets, in print (2016)
4. McBride DW, Tang J, Zhang JH, “Maintaining Plasma Fibrinogen Levels and Fibrinogen Replacement Therapies for Treatment of Intracranial Hemorrhage,” Curr Drug Targets, in print (2015)
5. Klebe D, Flores JJ, McBride DW, Zhang JH, Tang J, “Modulating the Immune Response Towards a Neural Regenerative Phenotype after Cerebral Hemorrhage,” J Neuroimmune Pharmacol, 10(4):576-86 (2015), DOI: 10.1007/s11481-015-9613-1
6. McBride DW, Wang Y, Adam L, Oudin G, Walker C, Louis J-S, Tang J, Zhang JH, “Correlation Between Subacute Sensorimotor Deficits and Brain Edema in Rats after Surgical Brain Injury,” Acta Neurochir Suppl, Proceed International Symposium Brain Edema XVI, 121:317-21 (2016), DOI: 10.1007/978-3-319-18497-5_55
7. McBride DW, Donovan V, Hsu M, Obenaus A, Rodgers VGJ, Binder DK, “Reduction of Cerebral Edema via an Osmotic Transport Device Improves Functional Outcome after Traumatic Brain Injury in Mice,” Acta Neurochir Suppl, Proceed International Symposium Brain Edema XVI, 121:285-9 (2016), DOI: 10.1007/978-3-319-18497-5_49
8. McBride DW, Matei N, Câmara JR, Louis J-S, Oudin G, Walker C, Adam L, Liang X, Hu Q, Tang J, Zhang JH, “Acute Hyperglycemia does not Effect Brain Swelling or Infarction Volume after Middle Cerebral Artery Occlusion in Rats,” Acta Neurochir Suppl, Proceed International Symposium Brain Edema XVI, 121:251-5 (2016), DOI: 10.1007/978-3-319-18497-5_44
9. McBride DW, Legrand J, Krafft PR, Tang J, Zhang JH, “Acute Hyperglycemia is Associated with Immediate Brain Swelling and Hemorrhagic Transformation after Middle Cerebral Artery Occlusion in Rats,” Acta Neurochir Suppl, Proceed International Symposium Brain Edema XVI, 121:237-41 (2016), DOI: 10.1007/978-3-319-18497-5_42
10. McBride DW, Jacob C, Doycheva D, Dixon BJ, Malaguit J, Lekic T, Tang J, Zhang JH, “Changes in Brain Swelling and Infarction Volume over Four Days after Hypoxia Ischemia in Neonatal Rats,” Acta Neurochir Suppl, Proceed International Symposium Brain Edema XVI, 121:111-4 (2016), DOI: 10.1007/978-3-319-18497-5_19
11. McBride DW, Tang J, Zhang JH, “Development of an Infarct Algorithm to Correct for Brain Swelling After Ischemic Stroke in Rats,” Acta Neurochir Suppl, Proceed International Symposium Brain Edema XVI, 121:103-9 (2016), DOI: 10.1007/978-3-319-18497-5_18
12. Lekic T, Hardy M, Fujii M, McBride DW, Zhang JH, “Brain Volume Determination in Subarachnoid Hemorrhage Using Rats,” Acta Neurochir Suppl, Proceed International Symposium Brain Edema XVI, 121:99-102 (2016), DOI: 10.1007/978-3-319-18497-5_17
13. McBride DW, Wang Y, Sherchan P, Tang J, Zhang JH, “Correlation Between Subacute Sensorimotor Deficits and Brain Water Content After Surgical Brain Injury in Rats,” Behav Brain Res, 290:161-71 (2015), DOI: 10.1016/j.bbr.2015.05.001
14. McBride DW, Klebe D, Tang J, Zhang JH, “Correcting for Brain Swelling’s Effects on Infarct Volume Calculation After Middle Cerebral Artery Occlusion in Rats,” Trans Stroke Res, 6(4):323-38 (2015), DOI: 10.1007/s12975-015-0400-3
15. Lekic T, Klebe D, McBride DW, Manaenko A, Flores JJ, Altay O, Rolland WB, Tang J, Zhang JH, “Protease-Activated Receptor 1 and 4 Signaling Inhibition Reduces Preterm Neonatal Hemorrhagic Brain Injury,” Stroke, 46(6):1710-3 (2015), DOI:10.1161/STROKEAHA.114.007889
16. Li L, McBride DW, Doycheva D, Dixon BJ, Krafft PR, Tang J, Zhou C, Zhang JH, “G-CSF Attenuates Neuroinflammation and Stabilizes the Blood-Brain Barrier via the PI3K/Akt/GSK-3 Signaling Pathway Following Neonatal Hypoxia-Ischemia in Rats,” Exp Neurol, DOI:10.1016/j.expneurol.2014.12.020
17. Li L, Klebe D, Doycheva D, McBride DW, Krafft PR, Flores J, Zhou C, Zhang JH, Tang J, “G-CSF Ameliorates Neuronal Apoptosis Through GSK-3 Inhibition Following Neonatal Hypoxia-Ischemia in Rats,” Exp Neurol, 263:141-9 (2015), 10.1016/j.expneurol.2014.10.004
18. Liang X, Hu Q, Li B, McBride D, Bian H, Spagnoli P, Chen D, Tang J, Zhang JH, “Follistatin-Like 1 Attenuates Apoptosis via Disco-Interacting Protein 2 Homolog A/Akt Pathway After Middle Cerebral Artery Occlusion in Rats,” Stroke, 45:3048-54, (2014), DOI: STROKEAHA.114.006092
19. McBride DW, Szu JI, Hale C, Hsu MS, Rodgers VGJ, Binder DK, “Reduction of Cerebral Edema Following a Severe TBI Using an Osmotic Transport Device,” J Neurotrauma, 31(23):1948-54, (2014), DOI: 10.1089/neu.2014.3439
20. McBride DW, Rodgers VGJ, “A Generalized Free-Solvent Model for the Osmotic Pressure of Multi-Component Solutions Containing Protein-Protein Interactions,” Math Biosci, 258:72-87 (2014), DOI: 10.1016/j.mbs.2014.04.002
21. Hong Y, Shao A, Wang J, Chen S, Wu H, McBride DW, Wu Q, Sun X, Zhang J, “Neuroprotective Effect of Hydrogen-Rich Saline Against Neurologic Damage ad Apoptosis in Early Brain Injury Following Subarachnoid Hemorrhage: Possible Role of the Akt/GSK3 Signaling Pathway,” PLOS One, 9(4):e96212 (2014), DOI: 10.1371/journal.pone.0096212
22. Krafft PR, McBride DW, Lekic T, Rolland WB, Mansell CE, Ma Q, Tang J, Zhang JH, “Correlation Between Subacute Sensorimotor Deficits and Brain Edema in Two Mouse Models of Intracerebral Hemorrhage,” Behav Brain Res, 264:151-60 (2014), DOI: 10.1016/j.bbr.2014.01.052
23. McBride DW, Rodgers VGJ, “Predicting the Activity Coefficients of Free-Solvent for Concentrated Globular Protein Solutions Using Independently Determined Physical Parameters,” PLoS One, 8(12):e81933 (2013), DOI: 10.1371/journal.pone.0081933
24. McBride DW, Rodgers VGJ, “Interpretation of Negative Second Virial Coefficients from Non-Attractive Protein Solution Osmotic Pressure Data: An Alternative Perspective,” Biophys Chem, 184:79-86 (2013), DOI: 10.1016/j.bpc.2013.09.005
25. Ornelas D, Ozaki NU, McBride DW, Rodgers VGJ, “Osmotic Pressure of Bovine Serum Albumin in the Presence of Calcium Chloride with Low Ionic Strength,” University of California Undergraduate Research Journal, VII:62 (2013)
26. McBride DW, Hsu MS, Rodgers VGJ, Binder DK, “Improved Survival Following Cerebral Edema Using a Novel Hollow Fiber-Hydrogel Device,” J Neurosurgery, 116(6):1389-94 (2012), DOI: 10.3171/2012.2.JNS111540
27. McBride DW, Rodgers VGJ, “Obtaining Protein Solvent Accessible Surface Area (SASA) when Structural Data is Unavailable Using Osmotic Pressure,” AIChE J, 58(4):1012-7 (2012), DOI: 10.1002/aic.12648

Book Chapters
1. Esfahani ET, McBride DW, Shafiei SB, Obenaus A, “A Real-Time Analysis of Traumatic Brain Injury from T2 Weighted Magnetic Resonance Images Using a Symmetry-Based Algorithm,” Book Chapter in Video Bioinformatics, Springer, accepted
2. McBride DW, Nowrangi D, Ho WM, Tang J, Zhang JH, “Inducing Hemorrhagic Transformation Following Middle Cerebral Artery Occlusion via Acute Hyperglycemia in Rats,” Book Chapter in Animal Models of Acute Neurological Injuries, Humana Press, under review
3. McBride DW, Lekic T, Tang J, Zhang JH, “A Rat Model of Cerebellar Hemorrhage using Bacterial Collagenase Injection,” Book Chapter in Animal Models of Acute Neurological Injuries, Humana Press, under review
4. Sherchan P, McBride DW, Akyol O, Huang L, Reis C, Kim C, Tang J, Zhang JH, “A Rat Model of Surgical Brain Injury,” Book Chapter in Animal Models of Acute Neurological Injuries, Humana Press, under review
5. Ho WM, Reis C, Akyol O, Cahill J, McBride D, Zhang JH, “Monofilament Perforation Subarachnoid Hemorrhage Rat Model,” Book Chapter in Animal Models of Acute Neurological Injuries, Humana Press, under review
6. Iniaghe LO, McBride DW, Lekic T, Tang J, Zhang JH, “Collagenase Induced Pontine Hemorrhage in Rats,” Book Chapter in Animal Models of Acute Neurological Injuries, Humana Press, under review