Laboratory of Devin McBride, Ph.D.

OVERVIEW

Research in the McBride Cerebrovascular Laboratory is focused on understanding the mechanisms causing delayed neurological deficits after subarachnoid hemorrhage (SAH) and identifying novel therapeutic targets. Our current work revolves around brain blood vessel constriction and microthrombosis which are thought to be major contributors to delayed neurological deficits after SAH. We are using animal models of SAH, as well as cell culture, to elucidate the pathophysiological mechanisms of delayed deficits and determine potential therapeutic targets to prevent such functional injury. We are also collaborating with Spiros Blackburn to identify the changes in coagulation and platelet function after SAH as potential biomarkers for delayed neurological deficits and poor outcome in patients.

Dr. Devin McBride is an Assistant Professor in the Department of Neurosurgery at the University of Texas Health Science Center at Houston. He obtained his Ph.D. in Bioengineering from the University of California, Riverside and trained as a postdoctoral fellow in John H. Zhang’s lab at Loma Linda University where he learned translational neuroscience focused on cerebrovascular diseases. Our laboratory is currently supported by a Brain Aneurysm Foundation grant.

About Devin McBride, PhD

CURRENT PROJECTS

  • Investigate the role of platelets in microthrombi formation after SAH
  • Determine the therapeutic potential of galantamine for preventing inflammation after SAH
  • Evaluate the haptoglobin-CD163 axis for hemoglobin clearance after SAH

TEAM MEMBERS

Remya Veettil, Ph.D., Postdoc

CONTACT

Email: [email protected]

Office Phone: 713-500-6169

SELECTED PUBLICATIONS

  1. Kumar PT, McBride DW, Dash P, Matsumura K, Rubi A, Blackburn SL, “Endothelial Cell Dysfunction and Injury in Subarachnoid Hemorrhage,” Mol Neurobiol, DOI: 10.1007/s12035-018-1213-7
  2. Blackburn S, Kumar PT, McBride D, Zeineddine HA, Leclerc J, Choi A, Dash P, Grotta J, Aronowski J, Doré S, “Unique Contribution of Haptoglobin and Haptoglobin Genotype in Aneurysmal Subarachnoid Hemorrhage,” Front Physiol, 9:592 (2018), DOI: 10.3389/fphys.2018.00592
  3. Gong L, Manaenko A, Fan R, Huang L, Enkhjargal B, McBride DW, Ding Y, Tang J, Xiao X, Zhang JH, “Osteopontin Attenuates Inflammation via JAK2/STAT1 Pathway in Hyperglycemic Rats after Intracerebral Hemorrhage,” Neuropharm, 138:160-169 (2018), DOI: 10.1016/j.neuropharm.2018.06.009
  4. Ho W-M, Akyol O, Reis H, Reis C, McBride DW, Thome C, Zhang JH, “Autophagy after Subarachnoid Hemorrhage: Can Cell Death be Good?” Curr Neuropharm, DOI: 10.2174/1570159X15666171123200646
  5. Zhang Y, Ding Y, Lu T, Zhang Y, Xu N, McBride DW, Tang J, Zhang JH, “Biliverdin Reductase-A Attenuated GMH-Induced Inflammatory Response in the Spleen by Inhibiting Toll-Like Receptor-4 through eNOS/NO Pathway,” J Neuroinflammation, 15:118 (2018), DOI: 10.1186/s12974-018-1155-z
  6. Zhang Y, Ding Y, Lu T, Zhang Y, Xu N, Yu L, McBride DW, Flores JJ, Tang J, Zhang JH, “Biliverdin Reductase-A Improves Neurological Function in a Germinal Matrix Hemorrhage Rat Model,” Neurobiol Dis, 110:122-132 (2018), DOI: 10.1016/j.nbd.2017.11.017
  7. McBride DW, Nowrangi D, Kaur H, Wu G, Huang L, Lekic T, Tang J, Zhang JH, “A Composite Neurobehavioral Test to Evaluate Acute Functional Deficits after Cerebellar Hemorrhage in Rats,” J Cereb Blood Flow Metab, 38(3):433-446 (2018), DOI: 10.1177/0271678X17696509
  8. McBride DW, Blackburn S, Kumar T P, Matsumura K, Zhang JH, “The Role of Thromboinflammation in Delayed Cerebral Ischemia after Subarachnoid Hemorrhage,” Front Neurol, 8:555 (2017), DOI: 10.3389/fneur.2017.00555
  9. Krafft PR, McBride DW, Rolland WB, Lekic T, Flores JJ, Tang J, Zhang JH, “a7 Nicotinic Acetylcholine Receptor Stimulation Attenuates Neuroinflammation through JAK2-STAT3 Activation in Murine Models of Intracerebral Hemorrhage,” BioMed Res Int, 2017:8134653 (2017), DOI: 10.1155/2017/8134653
  10. Klebe D, Flores JJ, McBride DW, Krafft PR, Rolland WB, Lekic T, Zhang JH, “Dabigatran Ameliorates Post-Haemorrhagic Hydrocephalus Development after Germinal Matrix Haemorrhage in Neonatal Rat Pups,” J Cereb Blood Flow Metab, 37(9):3135-3149 (2017), DOI: 10.1177/0271678X16684355
  11. Lekic T, Klebe D, Pichon P, Brankov K, Sultan S, McBride D, Casel D, Al-Bayati A, Ding Y, Tang J, Zhang JH, “Aligning Animal Models of Clinical Germinal Matrix Hemorrhage, From Basic Correlation to Therapeutic Approach,” Curr Drug Targets, 18(12):1316-1328 (2017), DOI: 10.2174/1389450117666160615100538
  12. McBride DW, Tang J, Zhang JH, “Maintaining Plasma Fibrinogen Levels and Fibrinogen Replacement Therapies for Treatment of Intracranial Hemorrhage,” Curr Drug Targets, 18(12):1349-1357 (2017), DOI: 10.2174/1389450117666151209123857
  13. Enkhjargal B, McBride DW, Manaenko A, Sakai Y, Tang J, Zhang JH, “Intranasal Administration of Vitamin D Attenuates Blood-Brain Barrier Disruption through Endogenous Upregulation of OPN and Activation of CD44/P-gp Glycosylation Signaling after Subarachnoid Hemorrhage in Rats,” J Cereb Blood Flow Metab, 37(7):2555-66 (2016), DOI: 10.1177/0271678X16671147
  14. Klebe D, Flores JJ, McBride DW, Zhang JH, Tang J, “Modulating the Immune Response Towards a Neuroregenerative Peri-Injury Milieu after Cerebral Hemorrhage,” J Neuroimmune Pharmacol, 10(4):576-86 (2015), DOI: 10.1007/s11481-015-9613-1
  15. Lekic T, Klebe D, McBride DW, Manaenko A, Flores JJ, Altay O, Rolland WB, Tang J, Zhang JH, “Protease-Activated Receptor 1 and 4 Signaling Inhibition Reduces Preterm Neonatal Hemorrhagic Brain Injury,” Stroke, 46(6):1710-3 (2015), DOI:10.1161/STROKEAHA.114.007889