Laboratory of Tiffany Chang, M.D.

OVERVIEW

Dr. Tiffany Chang’s laboratory focuses studying coagulation and platelet function in the setting of intracranial bleeding. In collaboration with the Neuroscience Research Repository (NRR), she is prospectively enrolling patients with intracerebral hemorrhage, subarachnoid hemorrhage and traumatic brain injury. Using thrombelastography (TEG), which analyzes the coagulation process and clot strength, she aims to understand how coagulation profiles relate to outcomes following brain injury. Dr. Chang additionally has served as our site Principal Investigator in several multicenter clinical trials for the treatment of intracerebral hemorrhage (ICH), including MISTIE III: Minimally Invasive Surgery plus rt-PA for ICH Evacuation and ATACH II: Antihypertensive Treatment of Acute Cerebral Hemorrhage.

Tiffany Chang, M.D. is currently an Assistant Professor at the University of Texas Health Science Center at Houston and also serves as the Director of the Neurocritical Care Fellowship Program. Dr. Chang received her undergraduate degree from the University of California, Los Angeles and her medical degree from the University of Hawaii John A. Burns School of Medicine. Her residency at Tulane University in New Orleans, Louisiana provided combined training in Internal Medicine and Neurology. Following residency, Dr. Chang completed a fellowship in Neurocritical Care at Johns Hopkins University in Baltimore, Maryland. She is board certified in Neurology, Internal Medicine, and Neurocritical Care.

CURRENT PROJECTS

1) Coagulation Outcome from Acute Neurologic Injury using Thrombelastography
2) Prospective Analysis of the use of Thrombelastography in Stroke Patients
3) MISTIE III: A Phase III, randomized, open-label, 500-subject clinical trial of minimally invasive surgery plus rt-PA in the treatment of intracerebral hemorrhage

TEAM MEMBERS

Tiffany Chang, MD Assistant Professor
Glenda Torres, MS Research Coordinator
Daniel Saenz, MS Research Assistant
Elena Espino, BS Research Assistant
Davis So, BS Research Assistant

CONTACT

Email: [email protected]
Office Phone: 713.500.6128

RECENT PUBLICATIONS

 

  1. Chang TR, Kowalski R, Carhuapoma JR, Tamargo RJ, Naval NS. Cocaine Use in an Independent Predictor of Seizures after Subarachnoid Hemorrhage. J Neurosurg, Mar 124(3):730-5, 2016.
  2. Chang TR, Kowalski R, Carhuapoma JR, Tamargo RJ, Naval NS. Impact of Case Volume on Aneurysmal Subarachnoid Hemorrhage Outcomes. J Crit Care, Jun 30(3):469-72, 2015.
  3. Naval NS, Kowalski RG, Chang TR, Caserta F, Carhuapoma JR, Tamargo RJ. The SAH Score: A Comprehensive Communication Tool. J Stroke Cerebrovasc Dis, May-Jun;23(5):902-9, 2014.
  4. Probasco JC, Chang TR, Victor D, Nyquist P. Isolated Pulmonary Edema without Myocardial Stunning in Brainstem Strokes. J Neurol Transl Neurosci, Jan 2(1): 1040, 2014.
  5. Kowalski RG, Chang TR, Carhuapoma JR, Tamargo RJ, Naval NS. Withdrawal of Technological Life Support Following Subarachnoid Hemorrhage. Neurocrit Care, Dec;19(3):269-75, 2013.
  6. Chang TR, Boehme AK, Aysenne A, Albright KC, Burns C, Beasley TM, Martin-Schild S. Nadir Hemoglobin is Associated with Poor Outcome from Intracerebral Hemorrhage. SpringerPlus, Aug 13;2:379, 2013.
  7. Chang TR, Kowalski R, Caserta F, Carhuapoma JR, Tamargo RJ, Naval NS. Impact of Acute Cocaine Use on Aneurysmal Subarachnoid Hemorrhage. Stroke, Jul 44(7):1825-9, 2013.
  8. Chang TR, Albright K, Boehme AK, Dorsey A, Sartor EA, Kruse-Jarres R, Leissinger C, Martin-Schild S. Factor VIII in the Setting of Acute Ischemic Stroke Among Patients with Suspected Hypercoagulable State. Clin Appl Thromb Hemost, Mar 20(2), 2014.Naval NS,
  9. Chang TR, Caserta F, Kowalski R, Carhuapoma JR, Tamargo RJ. Improved Aneurysmal Subarachnoid Hemorrhage outcomes: A comparison of 2 decades at an academic center. J Crit Care, Apr 28(2):182-8, 2013.
  10. Naval NS, Chang TR, Caserta F, Kowalski R, Carhuapoma JR, Tamargo RJ. Impact of Pattern of Admission on Outcomes following Aneurysmal Subarachnoid Hemorrhage. J Crit Care, Oct 27(5):532, 2012.
  11. Chang TR, Naval NS, Carhuapoma JR. Controversies in Neurosciences Critical Care. Anesthesiology Clin, Jun 30(2):369-83, 2012.