Laboratory of Manish N. Shah, M.D.

Overview

The Pediatric Neuroimaging laboratory led by Manish N. Shah, MD focuses on developing the next generation of advanced neuroimaging paradigms to improve both diagnostic and therapeutic paradigms in pediatric neurosurgical disease. Using resting state Blood Oxygen Level Dependent (BOLD) MRI, the laboratory investigates brain networks that are altered in pediatric diseases like epilepsy and cerebral palsy. A better understanding of the brain network malfunctions in these diseases will lead to a better understanding of their etiology and, ultimately, improved treatment paradigms.

Dr. Shah is a pediatric neurosurgeon who completed a postdoctoral research fellowship in the laboratory of Kavli-award winning Professor Marc Raichle at Washington University in St. Louis. Dr. Shah has won the AANS First Prize for Pediatrics Poster as well as the Washington University in St. Louis Neurosurgery Department Resident Research Award. He is the Director of Pediatric Spasticity and Movement Disorder Surgery at University of Texas Houston and Children’s Memorial Hermann Hospital as well as their pediatric epilepsy surgeon. Dr. Shah is the site investigator for the multi-institution Park-Reeves Chiari consortium, a network of centers investigating the optimal treatment of children with Chiari Malformations and syringomyelia.

Current Projects

  1. Investigation of resting state MRI alterations in medically-refractory pediatric epilepsy
  2. Investigation of resting state MRI alterations in pediatric spastic cerebral palsy
  3. Near-infrared optical tomography in pediatric neurosurgical disease
  4. Cost-effectiveness analysis of the patient care in the Park-Reeves Chiari/Syringomyelia Consortium

Team Members

Manish N. Shah, MD, Assistant Professor
Joseph Herbert, BA, Medical Student
Sid Venkataraman, BA, Medical Student

Contact

Email: [email protected]
Office Phone: 713-500-7370

Recent Publications

  • Leuthardt EC, Lim CC, Shah MN, Evans JA, Rich KM, Dacey RG, Tempelhoff R, Chicoine MR. Use of movable high-field-strength intraoperative magnetic resonance imaging with awake craniotomies for resection of gliomas: preliminary experience. Neurosurgery. 2011 Jul;69(1):194-205; discussion 205-6.
  • Shah MN, Petersen JD, Naidoo S, Woo AS, Kane AA, Smyth MD. “The St. Louis Children’s Hospital Experience with Endoscopically-assisted Sagittal Synostosis Repair.” J Neurosurg Pediatr. 2011 Aug;8(2):165-70.
  • Pizoli CE*, Shah MN*, Snyder AZ, Shimony JS, Limbrick DD, Raichle ME, Schlaggar BL, Smyth MD. “The Role of Resting State Functional Activity in Human Brain Development.” Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11638-43. *Co-first author
  • Shah MN, Leonard JR, Inder G, Gao F, Geske M, Haydon DH, Omodon ME, Evans J, Morales D, Dacey RG, Smyth MD, Chicoine MR, Limbrick DD. Intraoperative magnetic resonance imaging to reduce the rate of early reoperation for lesion resection in pediatric neurosurgery. J Neurosurg Pediatr. 2012 Mar;9(3):259-64.
  • Shah MN, Botros J, Pilgram T, Moran CJ, Cross DT, Chicoine MR, Rich KM, Dacey RG, Derdeyn CP and Zipfel GJ. “Borden-Shucart Type I dural arteriovenous fistulas: clinical course including risk of conversion to higher-grade fistulas.” J Neurosurg. 2012 Sep;117(3):539-45.
  • Shah MN, Stoev IT, Sanford DE, Gao F, Santiago P, Jaques DP, Dacey RG. “Are readmission rates on a neurosurgical service indicators of quality of care?” J Neurosurg. 2013 Oct;119(4):1043-9.
  • Vellimana AK, Daniels DJ, Shah MN, Zipfel GJ, Lanzino G. “Dural arteriovenous fistulas associated with benign meningeal tumors.” Acta Neurochir (Wien). 2014 Mar;156(3):535-44.
  • Zuckerman SL, Eli IM, Shah MN, Bradley N, Stutz CM, Park TS, Wellons JC 3rd.
    Radial to axillary nerve neurotization for brachial plexus injury in children: a combined case series. J Neurosurg Pediatr. 2014 Sep 5:1-9.
  • Sanford DE, Olsen MA, Bommarito KM, Shah M, Fields RC, Hawkins WG, Jaques DP, Linehan DC. “Association of discharge home with home health care and 30-day readmission after pancreatectomy,” J Am Coll Surg. 2014 Nov;219(5):875-86.e1.
  • Fakhri A1, Shah MN, Goyal MS. “Advanced Imaging of Chiari 1 Malformations.” Neurosurg Clin N Am. 2015 Oct;26(4):519-26.