Board Certifications

American Board of Psychiatry and Neurology

Dr. Jay-Jiguang Zhu earned his medical degree from McGill University in Montreal, Quebec, Canada. He completed his residency training in neurology at Tufts University School of Medicine in Boston, Mass. He subsequently completed his fellowship in neuro­oncology at Massachusetts General Hospital, Harvard Medical School in Boston.

Prior to entering medical school, Dr. Zhu received his doctorate in molecular biology at State University of New York in Buffalo, N.Y., and completed his post-doctoral training in CNS tumorigenesis research at Children’s Hospital, Brigham and Woman’s Hospital, Harvard Medical School.

Dr. Zhu was on the faculty of Tufts Medical Center and Tufts University School of Medicine where he served as an assistant professor and attending in neurology, hematology and oncology. His many honors and awards include CUSBEA scholar (China and United States Biochemistry Exchange Application), Massachusetts Medical Society Scholarships, the Abby H. Shevitz, M.D. Young Physician award, and Teaching Award from the class of 2002 at Tufts University School of Medicine.

For Patients

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Jay-Jiguang Zhu, MD, PhD


Graduate School
McGill University, Montreal, Quebec, Canada
Post Graduate School
State University of New York, Buffalo, New York (Molecular Biology)
Berkshire Medical Center, Pittsfield, Massachusetts
Tufts University School of Medicine, Boston, Massachusetts (Neurology)
Massachusetts General Hospital, Boston, Massachusetts (Neuro-Oncology)

Areas of Interest

Clinical Interests

Performing translational researches on identification of effective chemotherapies for primary brain tumors including malignant gliomas, meningiomas, PCNSL and brain metastasis.


  • Hwang, S, Eisenberg, RL,Yao, K, Pfannl, R, Mignano, J, Zhu, J. J., Strauss, G, Wu, J. Impact of Gamma Knife after Surgical Resection of Brain Metastases. Neuro-oncology, 2009, pending publication
  • Zhu, J. J., Gerstner, ER. Engler D. Mrugala M. Nugent W. Nierenberg K. Hochberg F. Betensky R. Batchelor, TT. High-dose methotrexate for elderly patients with primary CNS lymphoma. Neuro-oncology. 11: 211-215, 2009
  • Gaviani, P; Gonzalez, R G.; Zhu, J. J.; Batchelor, T T.; Henson, J W. Central neurogenic hyperventilation and lactate production in brainstem glioma. Neurology. 64(1):166-167, January 11, 2005.
  • Wilson J. C., Zhu, J. J., Black P. McL. The p27/Kip1 locus shows no loss of heterozygosity in human pituitary adenomas. 1999. J. of Neuro-Oncology, 44 (1):35-9.
  • Zhu, J. J., Maruyama T., Jacoby L. B., Herman J. G., Gusella J. F., Black P. McL. and Wu J. K., Clonal analysis of a case of multiple meningiomas using multiple molecular genetic approaches. 1999. Neurosurgery. 45(2):409-416.
  • Le S. Zhu, J. J., Anthony D. Greider C., Black P. McL., Telomerase activity in human gliomas. 1998, Neurosurgery.42:1120-1124.
  • Zhu, J. J., Santarius T., Wu X., Tsong J., Guha A., Wu J. K., Hudson T. J. and Black P. McL., Screening for loss of heterozygosity and microsatellite instability in oligodendrogliomas. 1998, Genes, Chromosomes and Cancer. 21:207-216.
  • Zhu, J. J., Leon, S., Guo S. Z., Folkerth, R. D., Wu J. K. and Black P. McL., Evidence for Clonal Origin of Neuronal and Glial Neoplastic Cells in Gangliogliomas. 1997, American J. of Pathology, 151, 565-571.
  • Kirsch, M., Zhu, J. J. and Black P. McL., Loss of heterozygosity analysis of BRCA-1 and BRCA-2 genes in meningiomas. 1997. Genes, Chromosomes and Cancer, 20:53-59.
  • Zhu J., Guo S. Z., Beggs A. H., Dashner K., Olson N., Wu J. K. and Black P. McL., Microsatellite Instability Analysis of Primary Human Brain Tumors. 1996. Oncogene, 12, 1417-1423.