Laboratory of Eunsu Park, PhD

Laboratory of Glia Biology in Cerebrovascular Disease

We are exploring the role of glia (microglia and astrocytes) in the pathology of cerebrovascular/neurological disease (brain arteriovenous malformation, stroke, Parkinson’s disease, Alzheimer’s disease, and aging). We specifically focus on the cross-talk mechanisms between glia and cells in the blood-brain barrier (BBB), blood immune cells, and neurons. In cerebrovascular disease, we recently established a novel brain arteriovenous malformation (bAVM)/intracerebral hemorrhage (ICH) mouse model by overexpression of mutant KRAS (oncogene) in endothelial cells (Park et al., 2021 Annals of Neurology, https://pubmed.ncbi.nlm.nih.gov/33675084/).

Using the cerebrovascular and neurological disease mouse model, we explore the molecular and genetic mechanisms, biomarkers, and immune system changes. In addition, we collaborate with research clinicians by sharing resources from human patients. The translational approaches using animal models with risk factors and collaborating with clinical teams will narrow the gap between the pre-clinical and clinical settings and facilitate our ultimate goal of developing therapeutic strategies for patients.

Current Projects

  • Role of microglia/macrophages in KRAS mutation-induced brain arteriovenous malformations and spontaneous intracerebral hemorrhage
  • Role of microglia/astrocytes in the microvascular side of neurodegeneration and aging
  • Blood-brain barrier in brain arteriovenous malformations, neurodegeneration, and aging

Team Members

Eunsu Park, PhD. Assistant Professor
About Eunsu Park. PhD.: Eunsu Park, PhD | McGovern Medical School (uth.edu)

Hyejin Park, PhD., Postdoctoral Fellow
Alexander Suh, BS., Research Assistant

Contact

Eunsu Park, PhD
Department of Neurosurgery
The University of Texas Health Science Center at Houston
6431 Fannin Street, MSB 7.147, Houston, TX, 77030 USA.
Office: MSB 7.132

Phone: (713) 500-5534
Email: [email protected]

Publications

https://www.ncbi.nlm.nih.gov/myncbi/eunsu.park.1/bibliography/public/