Current and Past Funding

RESEARCH SUPPORT 

NCI PREVENT TORFP 2023                                                                                                            12/1/23-11/30/26

Application PI

Targeting the A2B adenosine receptor for immunoprevention of pancreatic cancer

Multi PI: McAllister

The goal of this NCI contract is to study two orally bioavailable A2BR small molecule inhibitors in PDAC GEM models to assess clinical potential for immunoprevention.

 

R01CA277161_01A1                                                                                                      07/01/2023-06/30/2028

Bailey (PI) | Thosani (MPI)

 A single-arm phase II study to evaluate the safety and efficacy of combination systemic chemotherapy and multiple rounds of endoscopic ultrasound-guided radiofrequency ablation in pancreatic cancer 

 

NCI PREVENT TORFP 2020 E-10 (Bailey)                                                                             09/15/20-12/20/23

Preclinical testing of CD73 inhibitors for pancreatic cancer immunoprevention 

Role: Application PI

Multi PI: McAllister, Brown

The goal of this NCI contract is to study two orally bioavailable compounds in PDAC GEM models to assess clinical potential for immunoprevention.

 

1R21CA249924-01 (Bailey)                                                                                              01/2021-12/2023 NCI/NIH

Defining the role of Mst1/Mst2 in regulating metabolic alterations in Ras driven NSCLC

Role: PI

Multi PI: Ying

 

NIH/P30DK056338-18

Texas Digestive Disease Center Pilot Award                                                             01/2021-  12/2021

Adenosine Signaling in Pancreatitis associated with pancreatic ductal obstruction initiated by mutant Kras 

Role: PI

 

COMPLETED GRANT SUPPORT 

Plexxicon Contract                                                                                                                06/30/21-06/30/22

Testing CD73i oral gavage inhibitors for immunotherapy in pancreatic cancer.  

Role: PI

 

Pilot Grant                                                                                                                                  07/2021-06/2022

Center for Perioperative Medicine

Defining the role of a Hif2a/MiR-29 axis in T cell inflammation in inflammatory bowel disease 

Role: PI

 

Pilot Grant                                                                                                           07/2018- 07/2019

McGovern Medical School

Title: A functional genomics approach to define driver mutations in pancreatic cancer

Role: PI

 

Research Grant                                                                                                                      06/2017-06/2018

National Pancreas Foundation

Title: Can high Ras activity transform pancreatic ductal cells? 

Role: PI

 

P30DK056338-18                                                                                                                  03/2015-07/2016

Texas Digestive Disease Center Pilot Award

Title: Critical Mechanisms underlying pancreatic regeneration: a new role for p120 catenin 

Role: PI

 

AACR-PANCAN Pathway to Leadership Award (K99/R00 Like Grant)                            07/2011-08/2017

American Association for Cancer Research and The Pancreatic Cancer Action Network Title: Stop the Start: Novel Insights into PanIN Initiation and Progression 

Role: PI

 

NIH T35 DK007676-22                                                           Kone (PI)                             05/2017-08/2017

($106,000)/annually

Title: Aldh1a1: Hypoxic regulation of sphingosine signaling in pancreatic cancer

Role: Faculty Mentor; Student: Gary Chen

 

NIH T35 DK007676-22                                                           Kone (PI)                            05/2016-08/2016

($106,000)/annually

Title: Aldh1a1: Friend or Foe in pancreatic regeneration and pancreatitis? 

Role: Faculty Mentor; Student: Logan Oliver

 

NIH T35 DK007676-22                                                           Kone (PI)                             05/2016-08/2016

($106,000)/annually

Title: Defining a Stellate Cell Axis in Liver Disease and HCC

Role: Faculty Mentor; Student: Eric Yoon

 

NIH T35 DK007676-22                                                           Kone (PI)                          05/2015-08/2015

($106,000)/annually

Title: p120 catenin is required for regeneration of the exocrine pancreas in mice 

Role: Faculty Mentor; Student: Neal Jones

 

1F32 CA157044-01                                                                                                           07/2011-06/2014

National Institutes of Health-National Cancer Institute Ruth L. Kirschstein National Research Service Awards for Individual Postdoctoral Fellows (F32)

Title: Stopping the Start: Understanding PanIN Initiation and Progression 

Role: PI

 

Graduate Student Fellowship                                                                                      06/2006-06/2009

The Eppley Institute, University of Nebraska Medical Center

Title: Sonic Hedgehog Paracrine Signaling Promotes Metastasis and Lymphangiogenesis in Pancreatic Cancer 

Role: PI

 

NIH Cancer Biology Training Grant (T32)                                                                  06/2005-06/2006

Eppley Institute, University of Nebraska Medical Center

Title: Sonic Hedgehog Promotes Desmoplasia in Pancreatic Cancer 

Role: Trainee