Clinical Research


Nonallergic Rhinitis and its Management

The constellation of symptoms of rhinorrhea, nasal congestion, and nasal irritation, called rhinitis, can be related to non-allergic or allergic rhinitis. Non-allergic rhinitis is currently of diagnosis of exclusion. We validated the use of nasal provocation with intranasal capsaicin and an optical rhinometer, a device allowing for a non-invasive means of measuring blood flow through the nasal cavity and providing a means of evaluating nasal congestion, for the diagnosis of non-allergic rhinitis. We are currently conducting a clinical trial investigating the clinical efficacy of intranasal capsaicin for the management of nonallergic irritant rhinitis.

Key Publications

  • Luong A, Cheung EJ, Citardi MJ, and Batra PS. Evaluation of Optical Rhinometry for Nasal Provocation Testing in Allergic and Nonallergic Subjects. Otolaryngol-Head Neck Surg. 143(2):284-289, Aug 2010. PMID: 20647136.
  • Agarwal G, Hernandez D, Citardi MJ, Fakhri S, and Luong A. End-organ testing for allergic rhinitis with fungi is poorly correlated with fungal sensitivity. Otolaryngology-Head & Neck Surgery. 148(3):391-5, Mar 2013. PMID:23325707.
  • Lambert EL, Patel C, Fakhri SF, Citardi MJ, and Luong A. Optical rhinometry in non-allergic irritant rhinitis: A nasal capsaicin challenge. Int Forum of Allergy Rhinol, 2013 Oct;3(10):795-800. PMID:23733747.


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