Drug Delivery

Topical drug delivery for the treatment of inflammation of the lining of the nose and paranasal sinuses has been widely practiced for many years. For instance, inhaled nasal steroids are commonly used for the treatment of allergic rhinitis.

Topical medications may also be prescribed through a compounding pharmacy for the treatment of chronic rhinosinusitis, especially after sinus surgery. The drugs may be delivered to the sinuses via irrigation or nebulization. After sinus surgery, irrigation with saline serves to wash away thick mucus and other debris that otherwise may accumulate in sinus cavities. The irrigation may also be a carrier for the delivery of drugs (especially steroids) deep into the sinus spaces as a way to reduce inflammation of the sinus lining.

The Propel and Propel Mini are resorbable devices that deliver mometasone (a steroids) directly to the sinus lining. Several studies have confirmed the benefits of these devices, which seem to reduce the need for additional treatments. Originally designed for placement only at the time of surgery, these devices may also be placed into the surgically opened ethmoid cavity at any time point during regular office visits or during office procedures.