Education

Ecole Superieure des Techniques de Biologie Appliquees
Bachelor of Science in Biology, 1978
Ecole Pratique des Hautes Etudes
PhD in Pharmacology (with Honors), 1986

Areas of Interest

Research Interests

Awarded Grants

2016-2017
Principal Investigator
Amino Up (Sapporo, Japan)
Principal Investigator: Doursout MF (5% effort)
Title: Enzyme -Treated Asparagus Extract (ETAS) Promotes Anti-  Stress Effects Through Glutamate-Induced NF-kB Pathway in APP-overexpressed mice.
Allocated Amount: $56,000.

2017-2018
Principal Investigator
Cardiovascular research Alliance
Title: Application of Biological Pacemakers for Treatment of Sick Sinus Syndrome in Rats.
Allocated Amount: $130,000

Grants Pending

NIH RO1  (2017-2022)
Principal Investigator: Doursout MF (35% effort)
Title: Dietary Intervention and Mechanistic Insight into  Neurodegenerative Diseases

NIH RO1 (2017- 2022)
Principal Investigator:  Iraida Sharina
Co-Investigator: Doursout MF (10 % effort)
Title: Role of Nitric Oxide Receptor Soluble Guanylyl Cyclase in Age-Related Vascular Dysfunction

NIH RO1 (2017- 2022)
Principal Investigator:  Emil Martin
Co-Investigator: Doursout MF (10 % effort)
Title: Regulation of sGC Vascular Function by the Activator of   G-Protein Signaling 3.

National Science Fondation (NSF; 2018-2021)
PI: Marc Robert, PhD, Rice University
Co-Investigator: Doursout MF (5 % effort)
Title: Impact of Known Polymers and Newly Engineered Polymers on Rouleaux Formation and O2 Delivery in Rats.

Publications

 

Abstracts

1. Olamigoke L, Mann V, Mansoor E, Ellis I, Okoro E, Wakame K, Kulkarni A, Doursout MF and Sundaresan A. AHCC activation of human lymphocytes via genotypic, phenotypic, and differentiation pathways to an adherent cell type. A possible direct mechanism of T cell activation. 22nd European Low Gravity Research Association (ELGRA), Corfu, Greece, July 2015.

2. Doursout MF, Sundaresan A, Costa FS, Liang Y, Wakame K, Fujii H, and Kulkarni AL Oral administered active hexose correlated compound moderates LPS-induced hypotensive response and gut injury in rats.  23td International Congress on Nutrition and Integrative Medicine (ICNIM) Sapporo Japan, July 2015.

3. Sundaresan A, Olamigoke L, Mann V, Mansoor E, Ellis I, Okoro E, Fuji H, Sato A, Wakame K, Kulkarni A, and Doursout MF: AHCC mediates lymphocyte activation and promotes cell adhesion via direct targeting of T cell receptors and adhesion molecules. The 23td International Congress on Nutrition and Integrative Medicine (ICNIM) Sapporo Japan, July 2015.

4. Doursout Marie-Francoise, Payne JaNae, Yangyan Liang, Sundar Devakottai, Charles Wade and Nena Matijevic.  Impact of Microvesicles Pro-Inflammatory and Pro-Coagulant Properties on Sepsis-Induced Endothelium Dysfunction.  FASEB meeting, April 2016.

5. Doursout MF; Peng Z; Bedi S, Sundaresan A; Homma K; and Kulkarni AD. Neuroprotective effects of ETAS in APP overexpressed mice. The 25td International Congress on Nutrition and Integrative Medicine (ICNIM) Sapporo Japan. July 2017.

6. Sundaresan A, Olamigoke L, Mansoor E, Devakottai R, Reseland JE, Brungs S, Hemmesbach R, Mann V, Okoro E, Homma K, Kulkarni AD and Doursout MF: Alleviation of inflammation and stimulation of the immune response by Active Hexose Correlated Compound (AHCC) in stressful physiological environments.  Accepted. ISPS-7 & ELGRA-25, 2017.

 

Peer-Reviewed Articles

1. Doursout MF, Liang Y, Sundaresan A, Wakame K, Fujii H and Kulkarni A. Oral administered active hexose correlated compound moderates LPS-induced hypotensive response and gut injury in rats.  International Immunopharmacol 39:280-286, 2016.

2. Bick RJ, Doursout MF, Poindexter BJ: The complex cascade of Parkinson’s Disease.  J Nature Science (JNSCI) 2(11):e249, 2016

3. Nates J, Weavind L, Cattano D, Costa DS, Chelly JE, and Doursout MF: Thrombolastographic assessment of air, normal saline and mexiletine infusions on hemostasis in conscious rats.  Journal of Diving and Hyperbaric Medicine.  In Press

4. Bick Roger J. Poindexter B.J., Doursout MF. Vascular and immune cell content in a model of LPS-induced neurodegeneration using fluorescence deconvolution microscopy.  J Cytokine Biol 2017, volume 2, issue 2; 1-6, 2017.

5. Uray KL, Liang YY, Doursout MF:  Elevated left atrial pressure-induced prolonged pulmonary fibrosis:  development of an animal model. Submitted to AJP; 2017.