Biography

 

Hospital or Affiliated Institution Appointments:

06/1996 – 07/1998  Clinical Fellow, Department of Anesthesiology and Critical Care Medicine, University Hospital, Tübingen, Germany

07/1998 – 06/1999  Clinical Fellow, Division of Cardiac Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA

07/1999 – 07/2003  Clinical Fellow, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA

07/2003 – 08/2007  Assistant Professor, and Staff Anesthesiologist, Department of Anesthesiology and Critical Care Medicine, University Hospital, Tübingen, Germany

10/2004  Associate Professor (“Habilitation”), Department of Anesthesiology and Critical Care Medicine, University Hospital, Tübingen, Germany

01/2006 – 07/2007  Vice Chair (“Leitender Oberarzt”), Department of Anesthesiology and Critical Care Medicine, University Hospital, Tübingen, Germany

03/2007 – 07/2007  Professor, Department of Anesthesiology and Critical Care Medicine, University Hospital, Tübingen, Germany

08/2007 – 6/2010  Associate Professor, Department of Anesthesiology, University of Colorado, Aurora, Colorado

07/2010 – 8/2016  Professor and Tenure, Department of Anesthesiology, University of Colorado, Aurora, Colorado

10/2010 – 6/2013  Vice Chair for Research, Department of Anesthesiology, University of Colorado, Aurora, Colorado

06/2013 – 8/2016  Director, Organ Protection Program Departments of Anesthesiology, Surgery, Medicine, Emergency Medicine and Pediatrics; University of Colorado School of Medicine, Aurora, Colorado

11/2014 – 8/2016  Chief, Anesthesia Service for Oncologic Surgery, Department of Anesthesiology, University of Colorado School of Medicine, Aurora, Colorado

09/2016 – today  Director, Center for Perioperative Medicine Department of Anesthesiology, McGovern Medical School The University of Texas Health Science Center at Houston Houston, Texas

09/2016 – today  Associate Vice President for Translational Research The University of Texas Health Science Center at Houston Houston, Texas

09/2016 – 02/2017  Visiting Professor, Department of Anesthesiology, McGovern Medical School; The University of Texas Health Science Center at Houston, Houston, Texas

03/2017 – today  Professor with Tenure, Department of Anesthesiology McGovern Medical School; The University of Texas Health Science Center at Houston, Houston, Texas

09/2016 – 11/2016  Vice Chair for Research, Department of Anesthesiology, McGovern Medical School; The University of Texas Health Science Center at Houston, Houston, Texas

11/2016 – 08/2017  Chairman ad Interim, Department of Anesthesiology, McGovern Medical School; The University of Texas Health Science Center at Houston, Houston, Texas

02/2017 – 2019  John P. and Kathrine G. McGovern Distinguished Chair, Department of Anesthesiology, McGovern Medical School; The University of Texas Health Science Center at Houston, Houston, Texas

09/2017 – today  Chairman, Department of Anesthesiology, McGovern Medical School; The University of Texas Health Science Center at Houston, Houston, Texas

06/2019 – today  John P. and Kathrine G. McGovern Distinguished University Chair, Department of Anesthesiology, McGovern Medical School; The University of Texas Health Science Center at Houston, Houston, Texas

Professional Societies:

1992 – 1996  German National Scholarship Foundation

1996 – 2007  German Association of Physicians

1999 – present  American Society of Anesthesiologists

2003 – present  German Society of Anesthesia and Intensive Care Medicine

2007 – present  Colorado Society of Anesthesiologists

2008 – present  Association University Anesthesiologists

2008 – present  American Thoracic Society

2008 – present  International Anesthesia Research Society

2008 – present  American Society of Nephrology

2009 – present  American Association of Immunologists

2009 – present  American Society of Anesthesiologists

2009 – present  Elected Member, Association of University Anesthesiologists (AUA)

2011 – present  Elected Member, American Society of Clinical Investigation (one of 8 anesthesiologists in the history of ASCI)

2012 – present  Colorado Medical Society

2017 – present  Texas Society of Anesthesiologist (TSA)

2020 – present Member, Academy of Research Mentors, Foundation for Anesthesia Education and Research (FAER)

2021 – present  Elected Member, Association of American Physicians (one of 3 anesthesiologists in AAP)

Licensure and Certification:

03/1998  Certificate for Emergency Medicine Baden-Württemberg (“Fachkundenachweis, Mitwirkung im Rettungsdienst”)

05/2001  Perioperative Transesophageal Echocardiography Exam (National Board of Echocardiography)

09/2002  Massachusetts State Board of Registration

03/2003  German Board of Anesthesiology

05/2003  Transesophageal Echocardiography during Anesthesia and Critical Care Medicine, German Society of Anesthesiology and Intensive Care Medicine (DGAI)

10/2003  German Board of Intensive Care Medicine

10/2003  American Board of Anesthesiologists

10/2007  National Board of Echocardiography, Perioperative Transesophageal Echocardiography

07/2007  Colorado State Board of Registration

07/2013  Maintenance of Certification in Anesthesiology (MOCA)

Awards and Honors:

1996  German National Scholarship Foundation

1994  Poster Presentation Award, European Society of Regional Anesthesia (ESRA), Stockholm, Sweden

1996  Magna cum Laude, PhD Thesis, Eberhard-Karls-University, Tübingen, Germany

2003  Thomas Smith Lecture; Nucleotide Metabolism and Signaling, Harvard Medical School, Boston

2004  Hanse Research Award for Intensive Care Medicine, Bremen, Germany

2006  Hanse Research Award for Intensive Care Medicine, Bremen, Germany

2006  Heinrich-Dräger Research Award for Intensive Care Medicine, Leipzig, Germany

2007  Karl-Thomas Research Award for Anesthesiology, Intensive Care Medicine and Emergence Medicine,Hamburg, Germany

2008  BioSymposia Investigator Award, Ischemia and Inflammation Biosymposium, Boston, Massachusetts, USA

2009  Elect Member, Association of University Anesthesiologist (AUA)

2010-2013  Associate Editor, The Journal of Immunology

2010 Academic Editor, PLoS One

2011  Heinrich-Dräger Research Award for Intensive Care Medicine, Hamburg, Germany

2011  Elect Member, American Society of Clinical Investigation (ASCI)

2013  Section Editor, 1stTerm, The Journal of Immunology

2013  Associate Editor, Anesthesiology

2015  Section Editor, 2ndTerm, The Journal of Immunology

2015  Member, Editorial Board, Purinergic Signaling

2015  John Hedley-Whyte Lecture. The Hypoxia-Inflammation Link, Beth Israel Deaconess Hospital, Department of Anesthesiology, Harvard Medical School, Boston, USA

2016–present Permanent Member, NIH Study Section, Surgery, Anesthesia and Trauma (SAT), National Institutes of Health, Center for Scientific Review, Bethesda, MD

2017  John P. and Kathrine G. McGovern Distinguished Chair, Department of Anesthesiology, McGovern Medical School; The University of Texas Health Science Center at Houston, Houston, Texas

2019  Franz-Koehler Inflammation Award, German Society of Anaesthesiology and Intensive Care Medicine (DGAI), Berlin, Germany

06/2019–present John P. and Kathrine G. McGovern Distinguished University Chair, Department of Anesthesiology, McGovern Medical School; The University of Texas Health Science Center at Houston, Houston, Texas

2020  Member, Academy of Research Mentors, Foundation for Anesthesia Education and Research (FAER)

Education

MD
Eberhard-Karls-University, Tübingen, Germany
PhD
Eberhard-Karls-University, Tübingen, Germany
Residency in Anesthesiology and Critical Care Medicine
Tübingen University Clinic
Surgical Internship, Division of Cardiac Surgery
Brigham and Women’s Hospital, Harvard Medical School
Residency in Anesthesiology
Brigham and Women’s Hospital, Harvard Medical School
Clinical Fellowship in Cardiac Anesthesia and Perioperative Transesophageal Echocardiography
Brigham and Women’s Hospital, Harvard Medical School
Research Fellowship, Center for Experimental Therapeutics and Ischemia-Reperfusion Injury
Brigham and Women’s Hospital, Harvard Medical School
Habilitation
Eberhard-Karls-University, Tübingen, Germany

Research Information

The Eltzschig laboratory is interested in studying endogenous adaptive pathways that are under the control of hypoxia-inducible factors. These molecular concepts have been applied to a wide range of disease models that are important for the field of anesthesiology, critical care, and perioperative medicine, including acute lung injury, myocardial or hepatic ischemia, acute kidney injury, and intestinal inflammation. It is hoped that these studies contribute to novel pharmacologic approaches to prevent or treat acute organ injury in surgical patients.

Acute Lung Injury (ALI)
The research in the lung group focuses on understanding the inflammatory responses in acute lung injuries, including ventilation induced lung injury (VILI) and LPS-induced lung injury. Our recent studies of lung injuries focus on investigating the role of hypoxia-inducible factors (HIFs) and microRNAs in the underlying mechanisms of ALI.

Myocardial Ischemia
We are also interested in understanding cardio-protective mechanisms and targets during the Myocardial Ischemia/Reperfusion (IR) injury. Our recent studies showed that changes in metabolic supply and demand lead to the stabilization of hypoxia-inducible transcription factors during myocardial ischemia, resulting in upregulation of cardio-protective small molecules, such as epithelial growth factor amphiregulin (AREG).

Acute Kidney Injury (AKI)
Acute kidney injury (AKI) is a leading cause of morbidity and mortality of perioperative patients, and therapeutic approaches to prevent or treat AKI are limited. Our recent studies suggested that genetic deletion or pharmacologic inhibition of the renal proton pump ATP4A with proton pump inhibitors conveys very potent renal protection. We hope that our findings could support the potentials of proton pump inhibitors as therapeutic options to prevent or treat AKI.

Intestinal Inflammation
Numerous studies suggest that one of the key elements in inflammatory bowel diseases (IBD) is dysfunction of intestinal epithelial barrier function caused by intestinal inflammation. Our recent study found that an increase of adenosine levels in experimental colitis might exploit protective adenosine receptor signaling.

Publications

Publication Information

Dr. Eltzschig has published over 290 peer-reviewed research contributions, including first or senior author papers in Nature Medicine, Nature Immunology, Circulation, Gastroenterology, Gut, Science Translational Medicine, The Journal of Clinical Investigations, The Journal of Experimental Medicine, PLoS Medicine, PLoS Biology, Circulation Research, Blood, PNAS, Nature Communications and many other leading biomedical journals. Dr. Eltzschig is also the lead author on three review papers in the New England Journal of Medicine. In addition, he published review papers in Nature, Nature Medicine, Nature Reviews Drug Discovery, Blood and Anesthesiology that focus on his research findings. With an H-index of 84 and over 27,000 citations, Dr. Eltzschig is among the highest cited physician-scientists from the field of perioperative medicine.

Original Articles (Basic Science):

  1. Synnestvedt, K., G.T. Furuta, K.M. Comerford, N. Louis, J. Karhausen, H.K. Eltzschig, K.R. Hansen, L.F. Thompson, and S.P. Colgan. 2002. Ecto-5′-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia. J Clin Invest110:993-1002. (PMID: 12370277; PMCID: PMC151145)
  2. Eltzschig, H.K., J.C. Ibla, G.T. Furuta, M.O. Leonard, K.A. Jacobson, K. Enjyoji, S.C. Robson, and S.P. Colgan. 2003. Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptors. J Exp Med198:783-796. (PMID: 12939345; PMCID: PMC2194189)
  3. Kong, T., H.K. Eltzschig, J. Karhausen, S.P. Colgan, and C.S. Shelley. 2004. Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta-2 integrin gene expression. Proc. Nat Acad Sci (USA)101:10440-10445. (PMID: 15235127; PMCID: PMC478589)
  4. Eltzschig, H.K., L.F. Thompson, J. Karhausen, R.J. Cotta, J.C. Ibla, S.C. Robson, and S.P. Colgan. 2004. Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism. Blood104:3986-3992. (PMID: 15319286)
  5. Thompson, L.F., H.K. Eltzschig, J.C. Ibla, C.J. Van De Wiele, R. Resta, J.C. Morote-Garcia, and S.P. Colgan. 2004. Crucial Role for Ecto-5′-Nucleotidase (CD73) in Vascular Leakage during Hypoxia. J. Exp. Med.200:1395-1405. (PMID: 15583013; PMCID: PMC1237012)
  6. Eltzschig, H.K., P. Abdulla, E. Hoffman, K.E. Hamilton, D. Daniels, C. Schonfeld, M. Loffler, G. Reyes, M. Duszenko, J. Karhausen, A. Robinson, K.A. Westerman, I.R. Coe, and S.P. Colgan. 2005. HIF-1-dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia. J. Exp. Med.202:1493-1505. (PMID: 16330813; PMCID: PMC2213326)
  7. Dieterich, H.J., T. Weissmuller, P. Rosenberger, and H.K. Eltzschig. 2006. Effect of hydroxyethyl starch on vascular leak syndrome and neutrophil accumulation during hypoxia. Crit Care Med34:1775-1782.
    (PMID: 16625120)
  8. Eckle, T., A. Grenz, D. Kohler, A. Redel, M. Falk, B. Rolauffs, H. Osswald, F. Kehl, and H.K. Eltzschig. 2006. Systematic evaluation of a novel model for cardiac ischemic preconditioning in mice. Am J Physiol Heart Circ Physiol291:H2533-2540. (PMID: 16766632)
  9. Eltzschig, H.K., M. Faigle, S. Knapp, J. Karhausen, J. Ibla, P. Rosenberger, K.C. Odegard, P.C. Laussen, L.F. Thompson, and S.P. Colgan. 2006. Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26. Blood108:1602-1610.
    (PMID: 16670267; PMCID: PMC1895500)
  10. Kong, T., K.A. Westerman, M. Faigle,H.K. Eltzschig, and S.P. Colgan. 2006. HIF-dependent induction of adenosine A2B receptor in hypoxia. Faseb J20:2242-2250. (PMID: 17077301)
  11. Heinzelmann, F., V. Jendrossek, K. Lauber, K. Nowak, T. Eldh, R. Boras, R. Handrick, M. Henkel, C. Martin, S. Uhlig, D. Kohler, H.K. Eltzschig, M. Wehrmann, W. Budach, and C. Belka. 2006. Irradiation-induced pneumonitis mediated by the CD95/CD95-ligand system. J Natl Cancer Inst98:1248-1251. (PMID: 16954477)
  12. Eltzschig, H.K., T. Eckle, A. Mager, N. Kuper, C. Karcher, T. Weissmuller, K. Boengler, R. Schulz, S.C. Robson, and S.P. Colgan. 2006. ATP release from activated neutrophils occurs via connexin 43 and modulates adenosine-dependent endothelial cell function. Circ Res99:1100-1108. (PMID:17038639)
  13. Grenz, A., T. Eckle, H. Zhang, D.Y. Huang, M. Wehrmann, C. Kohle, K. Unertl, H. Osswald, and H.K. Eltzschig. 2007. Use of a hanging-weight system for isolated renal artery occlusion during ischemic preconditioning in mice. Am J Physiol Renal Physiol292:F475-F485. (PMID:16912063)
  14. Warth, A., T. Eckle, D. Kohler, M. Faigle, S. Zug, K. Klingel, H.K. Eltzschig, and H. Wolburg. 2007. Upregulation of the Water Channel Aquaporin-4 as a Potential Cause of Postischemic Cell Swelling in a Murine Model of Myocardial Infarction. Cardiology107:402-410. (PMID:17284903)
  15. Grenz, A., H. Zhang, T. Eckle, M. Mittelbronn, M. Wehrmann, C. Kohle, D. Kloor, L.F. Thompson, H. Osswald, and H.K. Eltzschig. 2007. Protective role of ecto-5′-nucleotidase (CD73) in renal ischemia. J Am Soc Nephrol18:833-845.(PMID:17267736)
  16. Eckle, T., T. Krahn, A. Grenz, D. Kohler, M. Mittelbronn, C. Ledent, M.A. Jacobson, H. Osswald, L.F. Thompson, K. Unertl, and H.K. Eltzschig. 2007. Cardioprotection by ecto-5′-nucleotidase (CD73) and A2B adenosine receptors. Circulation115:1581-1590. (PMID: 17353435)
  17. Grenz, A., H. Zhang, M. Hermes, T. Eckle, K. Klingel, D.Y. Huang, C.E. Muller, S.C. Robson, H. Osswald, and H.K. Eltzschig. 2007. Contribution of E-NTPDase1 (CD39) to renal protection from ischemia-reperfusion injury. FASEB J21:2863-2873. (PMID:17442731)
  18. Eckle, T., L. Fullbier, M. Wehrmann, J. Khoury, M. Mittelbronn, J. Ibla, P. Rosenberger, and H.K. Eltzschig. 2007. Identification of Ectonucleotidases CD39 and CD73 in Innate Protection during Acute Lung Injury. J Immunol178:8127-8137. (PMID: 7548651)
  19. Grenz, A., H. Zhang, J. Weingart, S. von Wietersheim, T. Eckle, J.B. Schnermann, C. Kohle, D. Kloor, C.H. Gleiter, V. Vallon, H.K. Eltzschig, and H. Osswald. 2007. Lack of effect of extracellular adenosine generation and signalling on renal erythropoietin secretion during hypoxia. Am J Physiol Renal Physiol00243.02007. (PMID: 17855480)
  20. Kohler, D., T. Eckle, M. Faigle, A. Grenz, M. Mittelbronn, S. Laucher, M.L. Hart, S.C. Robson, C.E. Muller, and H.K. Eltzschig. 2007. CD39/ecto-nucleoside triphosphate diphosphohydrolase 1 provides myocardial protection during cardiac ischemia/reperfusion injury. Circulation116:1784-1794. (PMID: 17909107)
  21. Kuhlicke, J., J.S. Frick, J.C. Morote-Garcia, P. Rosenberger, and H.K. Eltzschig. 2007. Hypoxia Inducible Factor (HIF)-1 Coordinates Induction of Toll-Like Receptors TLR2 and TLR6 during Hypoxia. PLoS ONE2:e1364. (PMID: 18159247; PMCID: PMC2147045)
  22. Redel, A., V. Jazbutyte, T.M. Smul, M. Lange, T. Eckle, H.K. Eltzschig, N. Roewer, and F. Kehl. 2008. Impact of ischemia and reperfusion times on myocardial infarct size in mice in vivo. Exp Biol Med (Maywood)233:84-93. (PMID: 18156310)
  23. Eckle, T., M. Faigle, A. Grenz, S. Laucher, L.F. Thompson, and H.K. Eltzschig. 2008. A2B adenosine receptor dampens hypoxia-induced vascular leak. Blood111:2024-2035. (PMID: 18056839; PMCID: PMC2739365)
  24. Hartmann, H.,*H.K. Eltzschig,*H. Wurz, K. Hantke, A. Rakin, A.S. Yazdi, G. Matteoli, E. Bohn, I.B. Autenrieth, J. Karhausen, D. Neumann, S.P. Colgan, and V.A. Kempf. 2008. Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores. Gastroenterology134:756-767 (*Contributed Equally). (PMID: 18325389)
  25. Morote-Garcia, J.C., P. Rosenberger, J. Kuhlicke, and H.K. Eltzschig. 2008. HIF-1-dependent repression of adenosine kinase attenuates hypoxia-induced vascular leak. Blood111:5571-5580. (PMID: 18309031)
  26. Hart, M.L., M. Henn, D. Kohler, D. Kloor, M. Mittelbronn, I.C. Gorzolla, G.L. Stahl, and H.K. Eltzschig. 2008. Role of extracellular nucleotide phosphohydrolysis in intestinal ischemia-reperfusion injury. FASEB J22:2784-2797. (PMID: 18353866; PMCID: PMC2493465)
  27. Hart, M.L., C. Much, D. Kohler, J. Schittenhelm, I.C. Gorzolla, G.L. Stahl, and H.K. Eltzschig. 2008. Use of a hanging-weight system for liver ischemic preconditioning in mice. Am J Physiol Gastrointest Liver Physiol294:G1431-1440. (PMID: 18436620)
  28. Hart, M.L., D. Kohler, T. Eckle, D. Kloor, G.L. Stahl, and H.K. Eltzschig. 2008. Direct treatment of mouse or human blood with soluble 5′-nucleotidase inhibits platelet aggregation. Arteriosclerosis Thrombombosis Vascular Biology28:1477-1483. (PMID: 18511695)
  29. Wellmann, S., M. Bettkober, A. Zelmer, K. Seeger, M. Faigle, H.K. Eltzschig, and C. Buhrer. 2008. Hypoxia upregulates the histone demethylase JMJD1A via HIF-1. Biochem Biophys Res Commun372:892-897.
    (PMID: 18538129)
  30. Grenz, A., H. Osswald, T. Eckle, D. Yang, H. Zhang, Z.V. Tran, K. Klingel, K. Ravid, and H.K. Eltzschig. 2008. The Reno-Vascular A2B Adenosine Receptor Protects the Kidney from Ischemia. PLoS Medicine5:e137.
    (PMID: 18578565; PMCID: PMC2504049)
  31. Faigle, M., J. Seessle, S. Zug, K.C. El Kasmi, and H.K. Eltzschig. 2008. ATP release from vascular endothelia occurs across Cx43 hemichannels and is attenuated during hypoxia. PLoS ONE3:e2801.
    (PMID: 18665255; PMCID: PMC2474679)
  32. Eckle, T., D. Kohler, R. Lehmann, K.C. El Kasmi, and H.K. Eltzschig. 2008. Hypoxia-Inducible Factor-1 Is Central to Cardioprotection: A New Paradigm for Ischemic Preconditioning. Circulation118:166-175. (PMID: 18591435)
  33. Eckle, T., L. Fullbier, A. Grenz, and H.K. Eltzschig. 2008. Usefulness of pressure-controlled ventilation at high inspiratory pressures to induce acute lung injury in mice. Am J Physiol Lung Cell Mol Physiol295:L718-724. (PMID: 18708630)
  34. Hart, M.L., C. Much, I.C. Gorzolla, J. Schittenhelm, D. Kloor, G.L. Stahl, and H.K. Eltzschig. 2008. Extracellular adenosine production by ecto-5′-nucleotidase protects during murine hepatic ischemic preconditioning. Gastroenterology135:1739-1750 e1733. (PMID: 18804111)
  35. Eckle, T., A. Grenz, S. Laucher, and H.K. Eltzschig. 2008. A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice. J Clin Invest118:3301-3315. (PMID: 18787641; PMCID: PMC2532979)
  36. Haeberle, H.A., C. Durrstein, P. Rosenberger, Y.M. Hosakote, J. Kuhlicke, V.A. Kempf, R.P. Garofalo, and H.K. Eltzschig. 2008. Oxygen-independent stabilization of hypoxia inducible factor (HIF)-1 during RSV infection. PLoS ONE3:e3352. (PMID: 18839041; PMCID: PMC2556398)
  37. Zheng, W., J. Kuhlicke, K. Jackel, H.K. Eltzschig, A. Singh, M. Sjoblom, B. Riederer, C. Weinhold, U. Seidler, S.P. Colgan, and J. Karhausen. 2009. Hypoxia inducible factor-1 (HIF-1)-mediated repression of cystic fibrosis transmembrane conductance regulator (CFTR) in the intestinal epithelium. FASEB J23:204-213. (PMID: 18779379; PMCID: PMC2626614)
  38. Reutershan, J., I. Vollmer, S. Stark, R. Wagner, K.C. Ngamsri, and H.K. Eltzschig.2009. Adenosine and inflammation: CD39 and CD73 are critical mediators in LPS-induced PMN trafficking into the lungs. FASEB J23:473-482. (PMID: 18838482)
  39. Eltzschig, H.K., D. Kohler, T. Eckle, T. Kong, S.C. Robson, and S.P. Colgan. 2009. Central role of Sp1-regulated CD39 in hypoxia/ischemia protection. Blood113:224-232. (PMID: 18812468; PMCID: PMC2614635)
  40. Chen, H., D. Yang, S.H. Carroll, H.K. Eltzschig, and K. Ravid. 2009. Activation of the macrophage A2b adenosine receptor regulates tumor necrosis factor-alpha levels following vascular injury. Exp Hematol37:533-538. (PMID: 19375644; PMCID: PMC5748295)
  41. Frick, J.S., C.F. MacManus, M. Scully, L.E. Glover, H.K. Eltzschig, and S.P. Colgan. 2009. Contribution of adenosine A2B receptors to inflammatory parameters of experimental colitis. J Immunol182:4957-4964. (PMID: 19342675; PMCID: PMC2831100)
  42. Hart, M.L., B. Jacobi, J. Schittenhelm, M. Henn, and H.K. Eltzschig. 2009. Cutting Edge: A2B Adenosine receptor signaling provides potent protection during intestinal ischemia/reperfusion injury. J Immunol182:3965-3968. (PMID: 19299692)
  43. Koeppen, M., T. Eckle, and H.K. Eltzschig. 2009. Selective deletion of the A1 adenosine receptor abolishes heart-rate slowing effects of intravascular adenosine in vivo. PLoS One4:e6784. (PMID: 19707555; PMCID: PMC2727950)
  44. Morote-Garcia, J.C., P. Rosenberger, N.M. Nivillac, I.R. Coe, and H.K. Eltzschig. 2009. Hypoxia-inducible factor-dependent repression of equilibrative nucleoside transporter 2 attenuates mucosal inflammation during intestinal hypoxia. Gastroenterology136:607-618. (PMID:19105964)
  45. Rosenberger, P., J.M. Schwab, V. Mirakaj, E. Masekowsky, A. Mager, J.C. Morote-Garcia, K. Unertl, and H.K. Eltzschig. 2009. Hypoxia-inducible factor-dependent induction of netrin-1 dampens inflammation caused by hypoxia. Nat Immunol10:195-202. (PMID: 19122655)
  46. Hart, M.L., I.C. Gorzolla, J. Schittenhelm, S.C. Robson, and H.K. Eltzschig. 2010. SP1-dependent induction of CD39 facilitates hepatic ischemic preconditioning. J Immunol184:4017-4024. (PMID: 20207994; PMCID: PMC2846294)
  47. Csoka, B., Z.H. Nemeth, P. Rosenberger, H.K. Eltzschig, Z. Spolarics, P. Pacher, Z. Selmeczy, B. Koscso, L. Himer, E.S. Vizi, M.R. Blackburn, E.A. Deitch, and G. Hasko. 2010. A2B adenosine receptors protect against sepsis-induced mortality by dampening excessive inflammation. J Immunol185:542-550.(PMID: 20505145; PMCID: PMC2938184)
  48. Schingnitz, U., K. Hartmann, C.F. Macmanus, T. Eckle, S. Zug, S.P. Colgan, and H.K. Eltzschig. 2010. Signaling through the A2B adenosine receptor dampens endotoxin-induced acute lung injury. J Immunol184:5271-5279.(PMID: 20348420; PMCID: PMC2858788)
  49. Grenz, A., J.H. Dalton, J.D. Bauerle, A. Badulak, D. Ridyard, A. Gandjeva, C.M. Aherne, K.S. Brodsky, J.-H. Kim, R.M. Tuder, and H.K. Eltzschig. 2011. Partial Netrin-1 Deficiency Aggravates Acute Kidney Injury. PLoS ONE6:e14812.(PMID: 21625583; PMCID: PMC3098227)
  50. Zhang, Y., Y. Dai, J. Wen, W. Zhang, A. Grenz, H. Sun, L. Tao, G. Lu, D.C. Alexander, M.V. Milburn, L. Carter-Dawson, D.E. Lewis, H.K. Eltzschig, R.E. Kellems, M.R. Blackburn, H.S. Juneja, and Y. Xia. 2011. Detrimental effects of adenosine signaling in sickle cell disease. Nat Med17:79-86.(PMID: 21170046; PMCID: PMC4838392)
  51. Koeppen, M., T. Eckle, and H.K. Eltzschig. 2011c. Pressure controlled ventilation to induce acute lung injury in mice. JoVE.(PMID: 21587159; PMCID: PMC3197099)
  52. Riegel, A.K., M. Faigle, S. Zug, P. Rosenberger, B. Robaye, J.M. Boeynaems, M. Idzko, and H.K. Eltzschig. 2011. Selective induction of endothelial P2Y6 nucleotide receptor promotes vascular inflammation. Blood117:2548-2555.(PMID: 21173118; PMCID: PMC3062416)
  53. Eckle, T., M. Koeppen, and H.K. Eltzschig. 2011. Use of a hanging weight system for coronary artery occlusion in mice. JoVE.(PMID: 21540816; PMCID: PMC3169250)
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  110. Kiers, D., B. Wielockx, E. Peters, L.T. van Eijk, J. Gerretsen, A. John, E. Janssen, R. Groeneveld, M. Peters, L. Damen, A.M. Meneses, A. Kruger, J.D. Langereis, A.L. Zomer, M.R. Blackburn, L.A. Joosten, M.G. Netea, N.P. Riksen, J.G. van der Hoeven, G.J. Scheffer, H.K. Eltzschig, P. Pickkers, and M. Kox. 2018. Short-Term Hypoxia Dampens Inflammation in vivo via Enhanced Adenosine Release and Adenosine 2B Receptor Stimulation. EBioMedicine(PMID: 29983349; PMCID: PMC6085583)
  111. Liu, H., M. Adebiyi, R.R. Liu, A. Song, J. Manalo, Y.E. Wen, A.Q. Wen, T. Weng, J. Ko, M. Idowu, R.E. Kellems, H.K. Eltzschig, M.R. Blackburn, H.S. Juneja, and Y. Xia. 2018. Elevated ecto-5′-nucleotidase: a missing pathogenic factor and new therapeutic target for sickle cell disease. Blood Adv2:1957-1968. (PMID: 30097462; PMCID: PMC6093737)
  112. Aherne, C.M., C.B. Collins, C.R. Rapp, K.E. Olli, L. Perrenoud, P. Jedlicka, J.L. Bowser, T.W. Mills, H. Karmouty-Quintana, M.R. Blackburn, and H.K. Eltzschig.2018. Coordination of ENT2-dependent adenosine transport and signaling dampens mucosal inflammation.JCI Insight3: PMID: 30333323; PMCID: PMC6237472)
  113. Hadi, T., L. Boytard, M. Silvestro, D. Alebrahim, S. Jacob, J. Feinstein, K. Barone, W. Spiro, S. Hutchison, R. Simon, D. Rateri, F. Pinet, D. Fenyo, M. Adelman, K.J. Moore, H.K. Eltzschig, A. Daugherty, and B. Ramkhelawon. 2018. Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells. Nat Commun9:5022.(PMID: 30479344; PMCID: PMC6258757)
  114. Zhu, S., J. Zhu, G. Zhen, Y. Hu, S. An, Y. Li, Q. Zheng, Z. Chen, Y. Yang, M. Wan, R.L. Skolasky, Y. Cao, T. Wu, B. Gao, M. Yang, M. Gao, J. Kuliwaba, S. Ni, L. Wang, C. Wu, D. Findlay, H.K. Eltzschig,H.W. Ouyang, J. Crane, F.Q. Zhou, Y. Guan, X. Dong, and X. Cao. 2019. Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain. J Clin Invest129:1076-1093. (PMID: 30530994; PMCID: PMC6391093)
  115. Tseng, C., K. Sinha, H. Pan, Y. Cui, P. Guo, C.Y. Lin, F. Yang, Z. Deng,H.K. Eltzschig, A. Lu, and J. Huard. 2019. Markers of Accelerated Skeletal Muscle Regenerative Response in Murphy Roths Large Mice: Characteristics of Muscle Progenitor Cells and Circulating Factors. Stem Cells37:357-367 (PMID: 30537304; PMCID: PMC6393170)
  116. Sinha, K.M., C. Tseng, P. Guo, A. Lu, H. Pan, X. Gao, R. Andrews, H. Eltzschig, and J. Huard. 2019. Hypoxia-inducible factor 1alpha (HIF-1alpha) is a major determinant in the enhanced function of muscle-derived progenitors from MRL/MpJ mice. FASEB Jfj201801794R [Epub ahead of print] (PMID: 30970214)
  117. Deng, Z., X. Gao, X. Sun, S. Amra, A. Lu, Y. Cui, H.K. Eltzschig, G. Lei, and J. Huard. 2019. Characterization of articular cartilage homeostasis and the mechanism of superior cartilage regeneration of MRL/MpJ mice. FASEB J fj201802132RR.[Epub ahead of print] (PMID: 31042406)
  118. Yuan, X., C.Y. Chang, R. You, M. Shan, B.H. Gu, M. Madison, G. Diehl, S. Perusich, L.Z. Song, L. Cornwell, R.D. Rossen, R. Wetsel, R. Kimal, C. Coarfa, H. Eltzschig, D.B. Corry, and F. Kheradmand. 2019. Cigarette smoke-induced reduction of C1q promotes emphysema. JCI Insight 5:(PMID: 31112138)
  119. Gao, R.Y., M. Wang, Q. Liu, D. Feng, Y. Wen, Y. Xia, S.P. Colgan, H.K. Eltzschig, and C. Ju. 2019. Hypoxia-Inducible Factor (HIF)-2alpha Reprograms Liver Macrophages to Protect Against Acute Liver Injury via the Production of Interleukin-6. Hepatology (PMID: 31529728)
  120. Singh, K., M.A. Pruski, K. Polireddy, N.C. Jones, Q. Chen, J. Yao, W.A. Dar, F. McAllister, C. Ju, H.K. Eltzschig, M. Younes, C. Moran, H. Karmouty-Quintana, H. Ying, and J.M. Bailey. 2019. Mst1/2 kinases restrain transformation in a novel transgenic model of Ras driven non-small cell lung cancer. Oncogene. [Epub ahead of print] (PMID: 31570790)
  121. Lee, J.W., M. Koeppen, S.W. Seo, J.L. Bowser, X. Yuan, J. Li, M. Sibilia, A.V. Ambardekar, X. Zhang, T. Eckle, S.H. Yoo, and H.K. Eltzschig. 2019. Transcription-independent Induction of ERBB1 through Hypoxia-inducible Factor 2A Provides Cardioprotection during Ischemia and Reperfusion. Anesthesiology [Epub ahead of print] (PMID: 31794514)
  122. Ibars, M., M.T. Maier, E. Yulyaningsih, L. Perez, R. Cheang, A. Vilhelmsson, S.M. Louie, S.A. Wegner, X. Yuan, H.K. Eltzschig, F.W. Hopf, D.K. Nomura, S.K. Koliwad, and A.W. Xu. 2020. Neuronal modulation of hepatic lipid accumulation induced by binge-like drinking. Am J Physiol Endocrinol Metab [epub ahead of print] (PMID: 32045262)
  123. Gnad, T., G. Navarro, M. Lahesmaa, L. Reverte-Salisa, F. Copperi, A. Cordomi, J. Naumann, A. Hochhauser, S. Haufs-Brusberg, D. Wenzel, F. Suhr, N. Z. Jespersen, C. Scheele, V. Tsvilovskyy, C. Brinkmann, J. Rittweger, C. Dani, M. Kranz, W. Deuther-Conrad, H. K. Eltzschig, T. Niemi, M. Taittonen, P. Brust, P. Nuutila, L. Pardo, B. K. Fleischmann, M. Bluher, R. Franco, W. Bloch, K. A. Virtanen, and A. Pfeifer. 2020. ‘Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity’, Cell Metab, 32: 56-70 e7. (PMID: 32589947; PMCID: PMC7437516)
  124. Uray, K. S., Z. Peng, D. Cattano, H. K. Eltzschig, and M. F. Doursout. 2020. Development of pulmonary fibrosis after heart failure induced by elevated left atrial pressure, Am J Transl Res, 12: 4639-47 (PMID: 32913537; PMCID: PMC7476151)
  125. Gao, R., X. Peng, C. Perry, H. Sun, A. Ntokou, C. Ryu, J. L. Gomez, B. C. Reeves, A. Walia, N. Kaminski, N. Neumark, G. Ishikawa, K. E. Black, L. P. Hariri, M. W. Moore, M. Gulati, R. J. Homer, D. M. Greif, H. K. Eltzschig, and E. L. Herzog. 2021. ‘Macrophage-derived netrin-1 drives adrenergic nerve-associated lung fibrosis’, J Clin Invest, 131. (PMID: 33393489; PMCID: PMC7773383)
  126. Wang, Y., Y. Yang, M. Wang, S. Wang, J.M. Jeong, L. Xu, Y. Wen, C. Emontzpohl, C.L. Atkins, K. Duong, N.F. Moreno, X. Yuan, D.R. Hall, W. Dar, D. Feng, B. Gao, Y. Xu, Z. Czigany, S.P. Colgan, J.S. Bynon, S. Akira, J.M. Brown, H.K. Eltzschig, E.A. Jacobsen, and C. Ju. 2021. Eosinophils attenuate hepatic ischemia-reperfusion injury in mice through ST2-dependent IL-13 production. Sci Transl Med 13 (579) (PMID: 33536281).
  127. Kim, B., Guaregua, V., Chen, X., Zhao, C., Yeow, W., Berg, NK, H.K. Eltzschig, Yuan, X. 2021. Characterization of a Murine Model System to Study MicroRNA-147 During Inflammatory Organ Injury Inflammation (PMID: 3356625; PMCID: PMC7873671)
  128. Vohwinkel, C.U., E.J. Coit, N. Burns, H. Elajaili, D. Hernandez-Saavedra, X. Yuan, T. Eckle, E. Nozik, R.M. Tuder, and H.K. Eltzschig. 2021. Targeting alveolar-specific succinate dehydrogenase A attenuates pulmonary inflammation during acute lung injury. FASEB J 35:e21468 (PMID: 33687752).
  129. Wang, W., N.Y. Chen, D. Ren, J. Davies, K. Philip, H.K. Eltzschig, M.R. Blackburn, B. Akkanti, H. Karmouty-Quintana, and T. Weng. 2021. Enhancing Extracellular Adenosine Levels Restores Barrier Function in Acute Lung Injury Through Expression of Focal Adhesion Proteins. Front Mol Biosci 8:636678 (PMID: 33778007; PMCID: PMC7987656).
  130. Berg, N. K., J. Li, B. Kim, T. Mills, G. Pei, Z. Zhao, X. Li, X. Zhang, W. Ruan, H. K. Eltzschig, and X. Yuan. 2021. ‘Hypoxia-inducible factor-dependent induction of myeloid-derived netrin-1 attenuates natural killer cell infiltration during endotoxin-induced lung injury’, FASEB J, 35: e21334.(PMID: 33715200)
  131. Ju, C., M. Wang, E. Tak, B. Kim, C. Emontzpohl, Y. Yang, X. Yuan, H. Kutay, Y. Liang, D. R. Hall, W. A. Dar, J. S. Bynon, P. Carmeliet, K. Ghoshal, and H. K. Eltzschig. 2021. ‘Hypoxia-inducible factor-1alpha-dependent induction of miR122 enhances hepatic ischemia tolerance’, J Clin Invest, 131.(PMID:33792566; PMCID: PMC8011886)
  132. Peng, Z., S. Bedi, V. Mann, A. Sundaresan, K. Homma, G. Gaskey, M. Kowada, S. Umar, A. D. Kulkarni, H. K. Eltzschig, and M. F. Doursout. 2021. ‘Neuroprotective Effects of Asparagus officinalis Stem Extract in Transgenic Mice Overexpressing Amyloid Precursor Protein’, J Immunol Res, 2021: 8121407.(PMID: 34046506; PMCID: PMC8128539)
  133. Li, J., C. Conrad, T. W. Mills, N. K. Berg, B. Kim, W. Ruan, J. W. Lee, X. Zhang, X. Yuan, and H. K. Eltzschig. 2021. ‘PMN-derived netrin-1 attenuates cardiac ischemia-reperfusion injury via myeloid ADORA2B signaling’, J Exp Med, 218. (PMID: 33891683; PMCID: PMC8077173)

Original Articles (Clinical Contributions)

  1. Eltzschig, H.K., R. Darsow, T.H. Schroeder, H. Hettesheimer, and H. Guggenberger. Effect of tracheal intubation or laryngeal mask airway insertion on intraocular pressure using balanced anesthesia with sevoflurane and remifentanil. J Clin Anesth13:264-267. (PMID: 11435050)
  2. Eltzschig, H.K., M. Posner, and F.D. Moore, Jr. 2002. The use of readily available equipment in a simple method for intraoperative monitoring of recurrent laryngeal nerve function during thyroid surgery: initial experience with more than 300 cases. Arch Surg137:452-456. (PMID: 11926951)
  3. Ehlers, R., E. Buttcher, H.K. Eltzschig, S. Kazmaier, S. Szabo, U. Helber, and H.M. Hoffmeister. 2002. Correlation between ST-T-segment changes with markers of hemostasis in patients with acute coronary syndromes. Cardiology98:40-45. (PMID: 12373046)
  4. Eltzschig, H.K., T.H. Schroeder, B.J. Eissler, T.W. Felbinger, R. Vonthein, R. Ehlers, and H. Guggenberger. The effect of remifentanil or fentanyl on postoperative vomiting and pain in children undergoing strabismus surgery. Anesth Analg94:1173-1177. (PMID: 11973184)
  5. Felbinger, T.W., D.A. Reuter, H.K. Eltzschig, K. Moerstedt, O. Goedje, and A.E. Goetz. 2002. Comparison of pulmonary arterial thermodilution and arterial pulse contour analysis: evaluation of a new algorithm.J Clin Anesth14:296-301. (PMID: 1208815)
  6. Dieterich, H.-J., J. Reutershan, T.W. Felbinger, and H.K. Eltzschig. 2003. Penetration of Intravenous Hydroxyethyl Starch into the Cerebrospinal Fluid in Patients with Impaired Blood-Brain Barrier Function. Anesth Analg96:1150-1154. (PMID: 12651675)
  7. Eltzschig, H.K., I.J. Kallmeyer, T. Mihaljevic, S. Alapati, and S.K. Shernan. 2003. A practical approach to a comprehensive epicardial and epiaortic echocardiographic examination. J Cardiothoracic Vasc Anesth17:422-429. (PMID: 12968228)
  8. Rosenberger, P., S.K. Shernan, T. Mihaljevic, and H.K. Eltzschig. 2004. Transesophageal echocardiography for detecting extrapulmonary thrombi during pulmonary embolectomy. Ann Thorac Surg78:862-866.
    (PMID: 15337008)
  9. Felbinger, T.W., D.A. Reuter, H.K. Eltzschig, J. Bayerlein, and A.E. Goetz. 2005. Cardiac index measurements during rapid preload changes: a comparison of pulmonary artery thermodilution with arterial pulse contour analysis. J Clin Anesth17:241-248. (PMID: 1590846)
  10. Dieterich, H.J., B. Neumeister, A. Agildere, and H.K. Eltzschig. 2005. Effect of intravenous hydroxyethyl starch on the accuracy of measuring hemoglobin concentration. J Clin Anesth17:249-254. (PMID: 15950847)
  11. Rosenberger, P., S.K. Shernan, P.S. Shekar, J.K. Tuli, T. Weissmuller, S.F. Aranki, and H.K. Eltzschig. 2006. Acute hemodynamic collapse after induction of general anesthesia for emergent pulmonary embolectomy. Anesth Analg102:1311-1315. (PMID: 16632801)
  12. Haeberle, H.A., B. Nohe, H.K. Eltzschig, K. Unertl, and H.J. Dieterich. 2006. Effect of synthetic colloids on major histocompatibility complex class II expression. J Clin Anesth18:96-101. (PMID: 16563325)
  13. Guggenberger, H., T.H. Schroeder, R. Vonthein, H.J. Dieterich, S.K. Shernan, and H.K. Eltzschig. 2006. Remifentanil or sufentanil for coronary surgery: comparison of postoperative respiratory impairment. Eur J Anaesthesiol1-9. (PMID: 16512971)
  14. Memtsoudis, S.G., P. Rosenberger, M. Loffler, H.K. Eltzschig, A. Mizuguchi, S.K. Shernan, and J.A. Fox. 2006. The usefulness of transesophageal echocardiography during intraoperative cardiac arrest in noncardiac surgery. Anesth Analg102:1653-1657. (PMID: 16717302)
  15. Eltzschig, H.K., P. Rosenberger, M. Loffler, J.A. Fox, S.F. Aranki, and S.K. Shernan. 2008. Impact of intraoperative transesophageal echocardiography on surgical decisions in 12,566 patients undergoing cardiac surgery. Ann Thorac Surg85:845-852. (PMID: 16512971)
  16. Rosenberger, P., S.K. Shernan, M. Loffler, P.S. Shekar, J.A. Fox, J.K. Tuli, M. Nowak, and H.K. Eltzschig. 2008. The influence of epiaortic ultrasonography on intraoperative surgical management in 6051 cardiac surgical patients. Ann Thorac Surg85:548-553. (PMID: 18222262)
  17. Hilberath, J.N., S.K. Shernan, S. Segal, B. Smith, and H.K. Eltzschig. 2009. The feasibility of epicardial echocardiography for measuring aortic valve area by the continuity equation. Anesth Analg108:17-22. (PMID:
  18. Riegel, A.K., Busch, R., Segal, S., Fox, J.A., Eltzschig, H.K., and Shernan, S.K. 2011. Evaluation of transmitral pressure gradients in the intraoperative echocardiographic diagnosis of mitral stenosis after mitral valve repair. PloS one6:e26559. (PMID: 19095825)
  19. Nowak-Machen, M., J.D. Rawn, P.S. Shekar, A. Mitani, S. Tuli, T.M. Bingold, G. Lawlor, H.K. Eltzschig, S.K. Shernan, and P. Rosenberger. 2012. Descending aortic calcification increases renal dysfunction and in-hospital mortality in cardiac surgery patients with intraaortic balloon pump counterpulsation placed perioperatively: a case control study. Crit Care16:R17. (PMID: 22277113; PMCID: PMC3396253)
  20. Hilberath, J.N., H.K. Eltzschig, S.K. Shernan, A.H. Worthington, S.F. Aranki, and M. Nowak-Machen. 2013. Intraoperative Evaluation of Transmitral Pressure Gradients after Edge-to-Edge Mitral Valve Repair. PLoS One8:e73617. (PMID: 24023891; PMCID: PMC3759443)
  21. Hilberath, J.N., P.S. Burrage, S.K. Shernan, D.J. Varelmann, K. Wilusz, J.A. Fox, H.K. Eltzschig, L.M. Epstein, and M. Nowak-Machen. 2014. Rescue transesophageal echocardiography for refractory haemodynamic instability during transvenous lead extraction. Eur Heart J Cardiovasc Imaging15:926-932. (PMID: 24686256)
  22. Burrage, P.S., S.K. Shernan, L.C. Tsen, J.A. Fox, K. Wilusz, H.K. Eltzschig, and J.N. Hilberath. 2015. Emergent transesophageal echocardiography in hemodynamically unstable obstetric patients. Int J Obstet Anesth24:131-136. (PMID: 25683381)
  23. Kork, F., F. Balzer, C.D. Spies, K.D. Wernecke, A.A. Ginde, J. Jankowski, and H.K. Eltzschig. 2015. Minor Postoperative Increases of Creatinine Are Associated with Higher Mortality and Longer Hospital Length of Stay in Surgical Patients. Anesthesiology 123:1301-1311. (PMID: 26492475; PMCID: PMC4679549)
  24. Kork, F., F. Balzer, A. Krannich, M.H. Bernardi, H.K. Eltzschig, J. Jankowski, and C. Spies. 2017. Back-calculating baseline creatinine overestimates prevalence of acute kidney injury with poor sensitivity. Acta Physiol (Oxf)219:613-624. (PMID: 27461744)
  25. Markham, T., R. Wegner, N. Hernandez, J.W. Lee, W. Choi, H.K. Eltzschig, and J. Zaki. 2018. Assessment of a multimodal analgesia protocol to allow the implementation of enhanced recovery after cardiac surgery: Retrospective analysis of patient outcomes. J Clin Anesth54:76-80. (PMID: 30412813)
  26. Hernandez, N., J. de Haan, D. Clendeninn, D.E. Meyer, S. Ghebremichael, C. Artime, G. Williams, H.K. Eltzschig, and S. Sen. 2019. Impact of serratus plane block on pain scores and incentive spirometry volumes after chest trauma. Local Regional Anesth 12:59-66.(PMID: 31447581; PMCID: PMC6684485)
  27. Liang, Y., A. Dhoble, A. Pakanati, Y. Zhao, F. Kork, W. Ruan, T. Markham, R. Smalling, P. Balan, A. Estrera, T. C. Nguyen, I. Gregoric, B. Kar, and Eltzschig. 2021. ‘Catastrophic Cardiac Events during Transcatheter Aortic Valve Replacement’, Can J Cardiol.(PMID: 33992736)

 Clinical Case Reports 

  1. Eltzschig, H.K., M. Rohrbach, and T.H. Schroeder. Methaemoglobinaemia after peribulbar blockade: an unusual complication in ophthalmic surgery. Br J Ophthalmol84:439e.(PMCID: PMC1723434)
  2. Eltzschig, H.K., G. Palmer, and R. Brustowicz. 2002. Colobronchial fistula in a pediatric patient: diagnostic value of isolated single-lung ventilation and intraoperative use of high frequency oscillatory ventilation. Anesth Analg95:621-623. (PMID: 12198048)
  3. Eltzschig, H.K., R.W. Lekowski, Jr., S.K. Shernan, S.S. Nedeljkovic, J.G. Byrne, R. Ehlers, and S.F. Aranki. 2002. Intraoperative transesophageal echocardiography to assess septic coronary embolism. Anesthesiology97:1627-1629. (PMID: 12459695)
  4. Eltzschig, H.K., T. Mihaljevic, J.G. Byrne, R. Ehlers, B. Smith, and S.K. Shernan. 2002. Echocardiographic evidence of right ventricular remodeling after transplantation. Ann Thorac Surg74:584-586. (PMID: 12173855)
  5. Edrich, T., S.K. Shernan, B. Smith, and H.K. Eltzschig. 2003. Usefulness of intraoperative epiaortic echocardiography to resolve discrepancy between transthoracic and transesophageal measurements of aortic valve gradient. Can J Anaesth50:293-296. (PMID: 12620954)
  6. Felbinger, T.W., R.W. Lekowski, Jr., S.K. Shernan, and H.K. Eltzschig. 2003. Images in Anesthesia: Detection of a defect pulmonary artery catheter balloon by transesophageal echocardiography. Can J Anaesth50:480.
    (PMID: 12734157)
  7. Frenk, V.E., S.K. Shernan, and H.K. Eltzschig. 2003. Epicardial echocardiography: diagnostic utility for evaluating aortic valve disease during coronary surgery. J Clin Anesth15:271-274. (PMID: 12888162)
  8. Edrich, T., T.W. Felbinger, P. Rosenberger, S.K. Shernan, and H.K. Eltzschig. 2003. Epicardial echocardiography intraoperative diagnostic utility to assess valve function. Anaesthesist52:1152-1157. (PMID: 14691629)
  9. Rosenberger, P., S.K. Shernan, S.C. Body, and H.K. Eltzschig. 2004. Utility of Intraoperative Transesophageal Echocardiography for Diagnosis of Pulmonary Embolism. Anesth Analg99:12-16. (PMID: 15281493)
  10. Eltzschig, H.K., S.K. Shernan, and P. Rosenberger. 2004. Ischemic Mitral Regurgitation during Temporary Coronary-Artery Ligation. N Engl J Med350:2424-2425. (PMID: 15175452)
  11. Edrich, T., A.D. Friedrich, H.K. Eltzschig, and T.W. Felbinger. 2004. Ketamine for Long-Term Sedation and Analgesia of a Burn Patient. Anesth Analg99:893-895. (PMID: 15333427)
  12. Eckle, T., N. Ghanayim, M. Trick, K. Unertl, and H.K. Eltzschig. 2005. Intraoperative metamizol as cause for acute anaphylactic collapse. Eur J Anaesthesiol22:810-812. (PMID: 16211791)
  13. Eltzschig, H.K., P. Rosenberger, R.W. Lekowski, Jr., J.D. Scott, A. Locke, P.S. Shekar, S.K. Shernan, and J.A. Fox. 2005. Role of transesophageal echocardiography in patients with suspected aortic dissection. J Am Soc Echocardiogr18:1221. (PMID: 16275534)
  14. Rosenberger, P., S.K. Shernan, J.D. Rawn, J. Scott, and H.K. Eltzschig. 2005. Critical role of inferior vena caval filter placement after pulmonary embolectomy. J Card Surg20:289-290. (PMID: 15854099)
  15. Felbinger, T.W., S.R. Mallampati, and H.K. Eltzschig. 2005. Airway management for postoperative respiratory failure: use of the laryngeal mask airway. Can J Anesth52:445-446. (PMID: 15814769)
  16. Richardson, S., R. Kacmar, J. Hawkins, H.K. Eltzschig, C. Kleck, E. Burger, and J. Hodges. 2016. Use of continuous fetal heart rate monitoring during discectomy at 24weeks of gestation. Int J Obstet Anesth25:95-96. (PMID: 26597410)

Reviews

  1. Eltzschig, H.K., A.E. Goetz, T.H. Schroeder, R. Ehlers, and T.W. Felbinger. 2002. Transesophageal echocardiography: perioperative evaluation of valvular function. Anaesthesist51:81-102. (PMID:11963310)
  2. Eltzschig, H.K., E.S. Lieberman, and W.R. Camann. Regional Anesthesia and Analgesia for Labor and Delivery. N Engl J Med348:319-332. (PMID: 12540646)
  3. Eltzschig, H.K., B. Zwissler, and T.W. Felbinger. Perioperative implications of heart transplantation. Anaesthesist52:678-689.
    (PMID: 12955268)
  4. Dieterich, H.J., H.K. Eltzschig, S.M. Kasper, C. Eingartner, and R.T. Grundmann. 2004. Hip prosthesis implantation–an interdisciplinary clinical pathway. Zentralbl Chir129:W38-56; quiz W57-60. (PMID: 15272506)
  5. Eltzschig, H.K., and C.D. Collard. 2004. Vascular ischaemia and reperfusion injury. Br Med Bull70:71-86. (PMID: 15494470)
  6. Mergner, D., P. Rosenberger, K. Unertl, and H.K. Eltzschig. 2005. Preoperative evaluation and perioperative management of patients with increased cardiovascular risk. Anaesthesist54:427-441. (PMID: 15815886)
  7. Rosenberger, P., and H.K. Eltzschig. 2005. Literature Review. J Cardiothoracic Vasc Anesth19:811-812.
  8. Weissmuller, T., H.K. Eltzschig, and S.P. Colgan. 2005. Dynamic purine signaling and metabolism during neutrophil-endothelial interactions. Purinergic Signalling1:229-239. (PMID: 18404508; PMCID: PMC2096542)
  9. Nowak, M., P. Rosenberger, T.W. Felbinger, A.E. Gotz, S.K. Shernan, K. Unertl, and H.K. Eltzschig. 2006. Perioperative echocardiography : Basic principles. Anaesthesist55:337-361. (PMID: 16520927)
  10. Hindler, K., H.K. Eltzschig, A.A. Fox, S.C. Body, S.K. Shernan, and C.D. Collard. 2006. Influence of Statins on Perioperative Outcomes. J Cardiothoracic Vasc Anesth20:251-258. (PMID: 16616673)
  11. Eltzschig, H.K., T. Weissmuller, A. Mager, and T. Eckle. 2006. Nucleotide metabolism and cell-cell interactions. Methods Mol Biol341:73-87.
    (PMID: 16799190)
  12. Colgan, S.P., H.K. Eltzschig, T. Eckle, and L.F. Thompson. 2006. Physiological Roles of 5′-Ectonucleotidase (CD73). Purinergic Signalling2:351-360. (PMCID: PMC2254482)
  13. Reeves, S.T., K.E. Glas, H.K. Eltzschig, J.P. Mathew, D.S. Rubenson, G.S. Hartman, and S.K. Shernan. 2007. Guidelines for performing a comprehensive epicardial echocardiography examination: recommendations of the American Society of Echocardiography and the Society of Cardiovascular Anesthesiologists. J Am Soc Echocardiogr20:427-437. (PMID: 17400124)
  14. Reeves, S.T., K.E. Glas, H.K. Eltzschig, J.P. Mathew, D.S. Rubenson, G.S. Hartman, and S.K. Shernan. 2007. Guidelines for performing a comprehensive epicardial echocardiography examination: recommendations of the American Society of Echocardiography and the Society of Cardiovascular Anesthesiologists. Anesth Analg105:22-28. (PMID: 17578948)
  15. Loffler, M., J.C. Morote-Garcia, S.A. Eltzschig, I.R. Coe, and H.K. Eltzschig. 2007. Physiological roles of vascular nucleoside transporters. Arteriosclerosis Thromb Vasc Biol27:1004-1013. (PMID: 17332491)
  16. Van Linden, A., and H.K. Eltzschig. 2007. Role of pulmonary adenosine during hypoxia: extracellular generation, signaling and metabolism by surface adenosine deaminase/CD26. Expert Opin Biol Ther7:1437-1447.
    (PMID: 17727332)
  17. Eltzschig, H.K., C.F. Macmanus, and S.P. Colgan. 2008. Neutrophils as Sources of Extracellular Nucleotides: Functional Consequences at the Vascular Interface. Trends Cardiovasc Med18:103-107. (PMID: 18436149)
  18. Eckle, T., M. Koeppen, and H.K. Eltzschig. 2009. Role of extracellular adenosine in acute lung injury. Physiology (Bethesda)24:298-306.
    (PMID: 19815856)
  19. Eltzschig, H.K. Adenosine: an old drug newly discovered. Anesthesiology111:904-915. (PMID: 19741501; PMCID: PMC2797575)
  20. Eltzschig, H.K., J. Rivera-Nieves, and S.P. Colgan. 2009. Targeting the A2B adenosine receptor during gastrointestinal ischemia and inflammation. Expert Opin Ther Targets13:1267-1277. (PMID: 19769545; PMCID: PMC4077533)
  21. Reuter, D.A., C. Huang, T. Edrich, S.K. Shernan, and H.K. Eltzschig. 2010. Cardiac output monitoring using indicator-dilution techniques: basics, limits, and perspectives. Anesth Analg110:799-811.(PMID: 20185659)
  22. Hilberath, J.N., D.A. Oakes, S.K. Shernan, B.E. Bulwer, M.N. D’Ambra, and H.K. Eltzschig. 2010. Safety of transesophageal echocardiography. J Am Soc Echocardiogr23:1115-1127; quiz 1220-1111(PMID: 20864313)
  23. Aherne, C.M., E.M. Kewley, and H.K. Eltzschig. 2011. The resurgence of A2B adenosine receptor signaling. Biochim Biophys Acta1808:1329-1339.(PMID: 20546702; PMCID: PMC2980804)
  24. Grenz, A., D. Homann, and H.K. Eltzschig. 2011. Extracellular adenosine: a safety signal that dampens hypoxia-induced inflammation during ischemia. Antioxid Redox Signal15:2221-2234. (PMID: 21126189; PMCID: PMC3166177)
  25. Bauerle, J.D., A. Grenz, J.H. Kim, H.T. Lee, and H.K. Eltzschig.2011. Adenosine generation and signaling during acute kidney injury. J Am Soc Nephrol22:14-20.(PMID: 21209250)
  26. Koeppen, M., T. Eckle, and H.K. Eltzschig. 2011. Interplay of Hypoxia and A(2B) Adenosine Receptors in Tissue Protection. Adv Pharmacol61:145-186.(PMID: 21586359)
  27. Koeppen, M., F. Di Virgilio, E.T. Clambey, and H.K. Eltzschig. 2011. Purinergic regulation of airway inflammation. Subcell Biochem55:159-193 (PMID: 21560048)
  28. Eltzschig, H.K., and P. Carmeliet. 2011. Hypoxia and Inflammation. N Engl J Med364:656-665.(PMID: 21323543; PMCID: PMC3930928)
  29. Eltzschig, H.K., and Eckle, T. 2011. Ischemia and reperfusion-from mechanism to translation. Nature medicine17:1391-1401.(PMID: 22064429; PMCID: PMC3886192)
  30. Grenz, A., E. Clambey, and H.K. Eltzschig. 2012. Hypoxia signaling during intestinal ischemia and inflammation. Curr Opin Crit Care18:178-185.(PMID: 22322265; PMCID: PMC3855266)
  31. Colgan, S.P., and H.K. Eltzschig. 2012. Adenosine and hypoxia-inducible factor signaling in intestinal injury and recovery. Annu Rev Physiol74:153-175. (PMID: 21942704; PMCID: PMC3882030)
  32. Eltzschig, H.K., M.V. Sitkovsky, and S.C. Robson. 2012. Purinergic Signaling during Inflammation. New England Journal of Medicine367:2322-2333.(PMID: 23534573)
  33. Poth, J.M., K. Brodsky, H. Ehrentraut, A. Grenz, and H.K. Eltzschig. 2013. Transcriptional control of adenosine signaling by hypoxia-inducible transcription factors during ischemic or inflammatory disease. J Mol Med91:183-193. (PMID: 23263788; PMCID: PMC3560301)
  34. Chen, J.F., H.K. Eltzschig, and B.B. Fredholm. 2013. Adenosine receptors as drug targets – what are the challenges? Nat Rev Drug Discov12:265-286.(PMID: 23535933; PMCID: PMC3930074)
  35. Dengler, V., G.P. Downey, R.M. Tuder, H.K. Eltzschig, and E.P. Schmidt. 2013. Neutrophil intercellular communication in acute lung injury. Emerging roles of microparticles and gap junctions. Am J Respir Cell Mol Biol49:1-5. (PMID: 23815257; PMCID: PMC3727882)
  36. Zimmerman, M.A., I. Kam, H. K. Eltzschig, and A. Grenz. 2013. Biological implications of extracellular adenosine in hepatic ischemia and reperfusion injury. Am J Transplant13:2524-2529. (PMID: 23924168; PMCID: PMC3805691)
  37. Eltzschig, H.K., S.K. Bonney, and T. Eckle. 2013. Attenuating myocardial ischemia by targeting A2B adenosine receptors. Trends Mol Med19:345-354.(PMID: 23540714; PMCID: PMC3674126)
  38. Bartels, K., J. Karhausen, E.T. Clambey, A. Grenz, and H.K. Eltzschig. 2013. Perioperative organ injury. Anesthesiology119:1474-1489. (PMID: 24126264; PMCID: PMC3929362)
  39. Aherne, C.M., C.B. Collins, and H.K. Eltzschig. 2013. Netrin-1 guides inflammatory cell migration to control mucosal immune responses during intestinal inflammation. Tissue Barriers1:e24957.(PMID: 24665394; PMCID: PMC3879190)
  40. Idzko, M., D. Ferrari, A.K. Riegel, and H.K. Eltzschig. 2014. Extracellular nucleotide and nucleoside signaling in vascular and blood disease. Blood124:1029-1037.(PMID: 25001468; PMCID: PMC4133480)
  41. Eltzschig, H.K., D.L. Bratton, and S.P. Colgan. 2014. Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases. Nat Rev Drug Discov13:852-869.(PMID: 25359381; PMCID: PMC4259899)
  42. Idzko, M., D. Ferrari, and H.K. Eltzschig. 2014. Nucleotide signalling during inflammation. Nature509:310-317.(PMID: 24828189; PMCID: PMC4222675)
  43. Vohwinkel, C.U., S. Hoegl, and H.K. Eltzschig. 2015. Hypoxia signaling during acute lung injury. J Appl Physiol(1985) jap 00226 02015.(PMID: 25977449; PMCID: PMC4816417)
  44. Hoegl, S., B. Zwissler, H.K. Eltzschig, and C. Vohwinkel. 2016. Acute respiratory distress syndrome following cardiovascular surgery: current concepts and novel therapeutic approaches. Curr Opin Anaesthesiol29:94-100.(PMID: 26598954; PMCID: PMC4689613)
  45. Neudecker, V., K.S. Brodsky, S. Kreth, A.A. Ginde, and H.K. Eltzschig. 2016. Emerging Roles for MicroRNAs in Perioperative Medicine. Anesthesiology124:489-506.(PMID: 26632665; PMCID: PMC4820395)
  46. Ferrari, D., N. Bianchi, H.K. Eltzschig, and R. Gambari. 2016. MicroRNAs Modulate the Purinergic Signaling Network. Trends Mol Med 22:905-918 (PMID: 27623176)
  47. Ferrari, D., E.N. McNamee, M. Idzko, R. Gambari, and H.K. Eltzschig. 2016. Purinergic Signaling During Immune Cell Trafficking. Trends Immunol37:399-411.(PMID: 27142306)
  48. Kiers, H.D., G.J. Scheffer, J.G. van der Hoeven, H.K. Eltzschig, P. Pickkers, and M. Kox. 2016. Immunologic Consequences of Hypoxia during Critical Illness. Anesthesiology125:237-249.(PMID: 27183167; PMCID: PMC5119461)
  49. Ju, C., S.P. Colgan, and H.K. Eltzschig. 2016. Hypoxia-inducible factors as molecular targets for liver diseases. J Mol Med94:613-627.(PMID: 27094811; PMCID: PMC4879168)
  50. Kork, F., C. Spies, R. Rossaint, and H. Eltzschig. 2016. Postoperative acute kidney injury: confounder or causal link for surgical outcome? Anasthesiol Intensivmed Notfallmed Schmerzther51:682-688.(PMID: 27884031)
  51. Bowser, J.L., J.W. Lee, X. Yuan, and H.K. Eltzschig. 2017. The Hypoxia-Adenosine Link during Inflammation. J Appl Physiol.jap 00101 02017.(PMID: 28798196; PMCID: PMC5792095)
  52. Sun, K., H. Liu, A. Song, J.M. Manalo, A. D’Alessandro, K.C. Hansen, R.E. Kellems, H.K. Eltzschig, M.R. Blackburn, R.C. Roach, and Y. Xia. 2017. Erythrocyte Purinergic Signaling Components Underlie Hypoxia Adaptation. J Appl Physiol jap 00155 02017. (PMID: 28572494; PMCID: PMC5668449)
  53. Neudecker, V., X. Yuan, J.L. Bowser, and H.K. Eltzschig. 2017. MicroRNAs in mucosal inflammation. J Mol Med (Berl) 95:935-949.(PMID: 28726085; PMCID: PMC5828032)
  54. Yuan, X., J.W. Lee, J.L. Bowser, V. Neudecker, S. Sridhar, and H.K. Eltzschig.2018. Targeting Hypoxia Signaling for Perioperative Organ Injury. Anesth Analg126:308-321. (PMID: 28759485; PMCID: PMC5735013)
  55. Bowser JL, Phan LH, and Eltzschig HK.The Hypoxia-Adenosine Link during Intestinal Inflammation. J Immunol.2018;200(3):897-907. (PMID: 29358413; PMCID: 5784778)
  56. Lim, G., F.L. Facco, N. Nathan, J.H. Waters, C.A. Wong, and H.K. Eltzschig. 2018. A Review of the Impact of Obstetric Anesthesia on Maternal and Neonatal Outcomes. Anesthesiology 129:192-215 (PMID:29561267; PMCID: PMC6008182)
  57. Yuan, X., N. Berg, J.W. Lee, T.T. Le, V. Neudecker, N. Jing, and H. Eltzschig. 2018. MicroRNA miR-223 as regulator of innate immunity. J Leukoc Biol104:515-524. (PMID: 29969525)
  58. Berg, N.K., H.K. Eltzschig, N. Vanga, L.J. Love, and O.O. Nwokolo. 2019. Perioperative Management of Disruptive Patients. Anesth Analg 128:587-591. (PMID: 30633055)
  59. Dar, W.A., E. Sullivan, J.S. Bynon, H.Eltzschig, and C. Ju. 2019. Ischemia Reperfusion Injury in Liver Transplantation: Cellular and Molecular mechanisms. Liver Int(PMID: 30843314)
  60. Lee, J.W., J. Ko, C. Ju, and H.K. Eltzschig. 2019. Hypoxia signaling in human diseases and therapeutic targets. Exp Mol Med51:68.(PMID: 31221962; PMCID: PMC6586801)
  61. Le, T.T., Berg, N.K., Harting, M.T., Li, X., H. Eltzschig, H.K., Yuan, X. Purinergic Signaling in Pulmonary Inflammation. Front Immunol. 2019 Jul 16;10:1633. doi: 10.3389/fimmu.2019.01633. eCollection 2019. Review. (PMID: 31379836)
  62. Gumbert, S.D., F. Kork, M.L. Jackson, N. Vanga, S.J. Ghebremichael, C.Y. Wang, and H.K. Eltzschig. 2019. Perioperative Acute Kidney Injury. Anesthesiology (PMID: 31687986)
  63. Cata, J. P., A. Gorur, X. Yuan, N. K. Berg, A. K. Sood, and K. Eltzschig. 2020. ‘Role of Micro-RNA for Pain After Surgery: Narrative Review of Animal and Human Studies’, Anesth Analg, 130: 1638-52.(PMID: 32384350)
  64. Lee, T. J., X. Yuan, K. Kerr, J. Y. Yoo, D. H. Kim, B. Kaur, and K. Eltzschig. 2020. ‘Strategies to Modulate MicroRNA Functions for the Treatment of Cancer or Organ Injury’, Pharmacol Rev, 72: 639-67.(PMID: 32554488; PMCID: PMC7300323)
  65. Lee, L. K., L. Medzikovic, M. Eghbali, K. Eltzschig, and X. Yuan. 2020. The Role of MicroRNAs in Acute Respiratory Distress Syndrome and Sepsis, From Targets to Therapies: A Narrative Review, Anesth Analg(PMID: 32889842)
  66. Conrad, C., and K. Eltzschig. 2020. Disease Mechanisms of Perioperative Organ Injury, Anesth Analg, 131: 1730-50. (PMID: 33186161; PMCID: PMC7673233)
  67. Williams, G.W., N.K. Berg, A. Reskallah, X. Yuan, and K. Eltzschig. 2020. Acute Respiratory Distress Syndrome: Contemporary Management and Novel Approaches during COVID-19. Anesthesiology, epub ahead of print. (PMID: 33016981)
  68. Ruan, W., X. Yuan, and K. Eltzschig. 2021. Circadian rhythm as a therapeutic target. Nat Rev Drug Discovin press (PMID: 33589815)

Comments and Editorials

  1. Eltzschig, H.K., and R. Ehlers. Noninvasive tests in patients with stable coronary artery disease. N Engl J Med345:1351. (PMID:11794164)
  2. Ehlers, R., T.W. Felbinger, and H.K. Eltzschig. 2002. Lowering cardiac risk in noncardiac surgery. N Engl J Med346:1096-1097. (PMID: 11932484)
  3. Camann, W., H.K. Eltzschig, and E. Lieberman. 2003. Regional Anesthesia and Analgesia for Labor and Delivery.N Engl J Med348:1818-1820.
    (PMID: 12540646)
  4. Eltzschig, H.K., and P. Rosenberger. 2003. Surgical Pulmonary Embolectomy. Thoraxcom 2003:
  5. Eltzschig, H.K., R. Ehlers, and S.K. Shernan. 2003. Heart Failure. N Engl J Med349:1002-1004. (PMID: 12954753)
  6. Rosenberger, P., S.K. Shernan, and H.K. Eltzschig. 2003. Perioperative pulmonary embolism. Anesth Analg97:1855. (PMID: 14633578)
  7. Rosenberger, P., S.K. Shernan, and H.K. Eltzschig. 2004. Suspected Pulmonary Embolism. N Engl J Med350:82-84. (PMID: 14708134)
  8. Eltzschig, H.K., D.J. Sugarbaker, and T.W. Felbinger. 2004. Effusive-Constrictive Pericarditis. N Engl J Med350:2310-2312. (PMID: 15163787)
  9. Eltzschig, H.K., H. Guggenberger, and S.R. Mallampati. 2004. Management of the anticipated difficult airway. J Clin Anesth16:396-397.
    (PMID: 15374566)
  10. Eltzschig, H.K., T. Eckle, and T.W. Felbinger. 2004. Management of Chronic Obstructive Pulmonary Disease. N Engl J Med351:1461-1463.
    (PMID: 15459312)
  11. Rosenberger, P., S.K. Shernan, T. Weissmuller, and H.K. Eltzschig. 2005. Role of intraoperative transesophageal echocardiography for diagnosing and managing pulmonary embolism in the perioperative period. Anesth Analg100:292-293. (PMID: 15616097)
  12. Rosenberger, P., S.K. Shernan, T. Mihaljevic, and H.K. Eltzschig. 2005. Transesophageal echocardiography for pulmonary embolectomy. Ann Thorac Surg79:1092-1093. (PMID: 15734454)
  13. Rosenberger, P., S.K. Shernan, S.C. Body, and H.K. Eltzschig. 2005. Visualization of Pulmonary Thromboemboli Using Epicardial Ultrasound. Anesth Analg100:601-a-.(PMID: 15673913)
  14. Eltzschig, H.K., and T. Eckle. 2005. Preoperative Revascularization to Prevent Perioperative Myocardial Infarction. Br J AnaesthISSN 1471-6771:
  15. Rosenberger, P., S.K. Sherman, T. Weissmuller, and H.K. Eltzschig. 2005. Usefulness of transesophageal echocardiography to diagnose perioperative pulmonary embolism. J Clin Anesth17:146-147. (PMID: 15809133)
  16. Eltzschig, H.K., and V.A. Kempf. Comments on Point: Counterpoint “Positive effects of intermittent hypoxia (live high:train low) on exercise performance are/are not mediated primarily by augmented red cell volume”. J Appl Physiol99:2456. (PMID: 16342386)
  17. Eltzschig, H.K., J. Karhausen, and V.A. Kempf. Acute oxygen-sensing mechanisms. N Engl J Med354:975-977. (PMID: 16514707)
  18. Nowak, M., H.K. Eltzschig, P. Shekar, S.K. Shernan, and P. Rosenberger. 2006. Critical role of intraoperative transesophageal echocardiography for detection of extrapulmonary thromboemboli during surgical pulmonary embolectomy. Anesthesiology104:1346. (PMID: 16732119)
  19. Eltzschig, H.K., K.C. El Kasmi, and T. Eckle. 2008. The HIF2A gene in familial erythrocytosis. N Engl J Med358:1965-1966. (PMID: 18450610)
  20. Eltzschig, H.K., T. Eckle, and A. Grenz. PHD2 mutation and congenital erythrocytosis with paraganglioma. N Engl J Med360:1361-1362.(PMID: 19321876)
  21. Eltzschig, H.K. Targeting Hypoxia-induced Inflammation. Anesthesiology114:239-242.(PMID: 21239967; PMCID: PMC3074366)
  22. Eckle, T., and H.K. Eltzschig. 2011. Toll-like receptor signaling during myocardial ischemia. Anesthesiology114:490-492.(PMID: 21278567; PMCID: PMC3073653)
  23. Eltzschig, H.K., and S.C. Robson. 2011. NT5E mutations and arterial calcifications. N Engl J Med364:1577-1578.(PMID: 21506753)
  24. Eltzschig, H.K. Extracellular adenosine signaling in molecular medicine. J Mol Med91:141-146. (PMID: 23338058; PMCID: PMC3563678)
  25. Eltzschig, H.K. Targeting purinergic signaling for perioperative organ protection. Anesthesiology118:1001-1004. (PMID: 23360900; PMCID: PMC3915407)
  26. Grenz, A., and H.K. Eltzschig. 2013. Mast cells and intestinal injury: a novel link between hypoxia and inflammation. Crit Care Med41:2246-2248. (PMID: 23979380; PMCID: PMC3856704)
  27. Eltzschig, H.K., M.V. Sitkovsky, and S.C. Robson. 2013. Purinergic signaling during inflammation. N Engl J Med368:1260. (PMID: 23534573)
  28. Bartels, K., A. Grenz, and H.K. Eltzschig. 2013. Hypoxia and inflammation are two sides of the same coin. Proc Natl Acad Sci U S A110:18351-18352. (PMID: 24187149; PMCID: PMC3831992)
  29. Bartels, K., B.L. Sullivan, and H.K. Eltzschig. 2014. TnT: blowing the cover from perioperative myocardial injury. Anesthesiology120:533-535. (PMID: 24534852; PMCID: PMC4222670)
  30. Bartels, K., A. Grenz, and H.K. Eltzschig. 2014. Transforming high risk to high yield. Anesthesiology120:1072-1074. (PMID: 24755782; PMCID: PMC4043957)
  31. Bartels, K., A. Grenz, and H.K. Eltzschig. 2014. Sphingosine-1-phosphate receptor signaling during acute kidney injury: the tissue is the issue. Kidney Int85:733-735. (PMID: 24682118; PMCID: PMC4007344)
  32. Koeppen, M., T. Eckle, and H.K. Eltzschig. 2015. Next Generation of Cardiovascular Studies: Transcriptional Responses of the Human Myocardium during Cardiac Surgery. Anesthesiology122:486-488. (PMID: 25569809; PMCID: PMC4333084)
  33. McNamee, E.N., C. Vohwinkel, and H.K. Eltzschig. 2016. Hydroxylation-independent HIF-1alpha stabilization through PKA: A new paradigm for hypoxia signaling. Sci Signal9:fs11. (PMID: 27245611)
  34. Neudecker, V., S.P. Colgan, and H.K. Eltzschig. 2017. Novel therapeutic concepts for inflammatory bowel disease – from bench to bedside. J Mol Med. (PMID: 28780611)
  35. Cata, J. P., A. K. Sood, and K. Eltzschig. 2020. Anesthetic Drugs and Cancer Progression, Anesthesiology, 133: 698-99.(PMID: 32833387; PMCID: PMC7494601)
  36. Kim, B., Y. Wang, and K. Eltzschig. 2020. ‘Kidney Protection: Strategies for Renal Preservation’, Anesth Analg, 131: e64-e65.(PMID: 33031665)
  37. Ruan, W., X. Yuan, and Eltzschig. 2021. ‘Circadian Mechanisms in Medicine’, N Engl J Med, 384: e76.(PIMD: 34010543)
  38. Yuan, X., D. Ferrari, T. Mills, Y. Wang, A. Czopik, M. F. Doursout, S. E. Evans, M. Idzko, and K. Eltzschig. 2021. ‘Editorial: Purinergic Signaling and Inflammation’, Front Immunol, 12: 699069. (PMID:34093597; PMCID: PMC8170313)
  39. Czopik, A., X. Yuan, S. E. Evans, and K. Eltzschig. 2021. ‘Targeting the Hypoxia-Adenosine Link for Controlling Excessive Inflammation’, Anesthesiology. (PMID:34046661)

Book Chapters

  1. Eltzschig, H.K. Ventricular Function. In Transesophageal Echocardiography. D.S. Morse, and C.D. Collard, editors. Lippincott Williams & Wilkins.
  2. Eltzschig, H.K. Anesthesia for trauma of the eye. In Trauma of the eye. J.M. Rohrbach, K.P. Steuhl, M. Knorr, and K. B., editors. Schattauer, Stuttgart, New York. 345-350.

Doctorate of Philosophy Dissertation 

Eltzschig, HK: Characterization of an Inhibitor of in vitroTranslation in Lysates of Trypanosoma brucei. Eberhard-Karls-University, Tübingen, Germany, 1996, 124 pgs.