Müller-Eberhard Memorial Lecture Set for April 8th

By Roman Petrowski, Office of Communications

Dr. Michael Carroll - Hans J. Müller-Eberhard Memorial Lecture
Michael Carroll, PhD

Michael Carroll, PhD, will present the 14th Hans J. Müller-Eberhard Memorial Lecture on “Complement C4 as a Risk Factor in Lupus and Schizophrenia,” at 11 a.m. April 8 in the Beth Robertson Auditorium at the Brown Foundation Institute of Molecular Medicine.

Carrol is a leading immunologist and internationally recognized for his scientific contributions to understanding the role of the complement system in murine humoral immunity and in the brain.  He cloned the first human complement gene (C4) and genetically mapped the two isoforms C4A and C4B.  He later showed that the C4A isoform was protective in murine lupus but in contrast a major risk factor for Schizophrenia.

Carroll received his PhD in Immunology from the UT Southwestern Medical School in Dallas under the direction of Dr. J. Donald Capra. Subsequently, he trained with Dr. Rodney R. Porter in the Biochemistry Department at Oxford University. In 1985, he was appointed an assistant professor in Pediatrics and the Department of Biological Chemistry at the Children’s Hospital/Harvard Medical School. He was promoted in 1998 to the rank of professor of Pediatrics at Harvard Medical School and senior investigator of the Boston Children’s Hospital program in Cellular and Molecular Medicine.

Carroll served as director of the Harvard Graduate Program in Immunology from 2005-16.  Early in his career, he was an American Arthritis Foundation Fellow and Investigator and later a recipient of a Pew Scholar award. He is a recipient of the 2016 Research Award by National Alliance for Mental Health and recently elected as a Distinguished Fellow of American Association of Immunologists class of 2022.

A major focus of his research is understanding how autoreactive germinal centers are regulated; and how peripheral autoimmunity can affect neuropsychiatric behavior.  Moreover, his research includes understanding how changes in the regulation of the complement system in the brain can underlie diseases such as schizophrenia.

This memorial lecture series honors the life and work of Hans J. Müller-Eberhard, MD, PhD, distinguished molecular immunologist, first holder of  the Cullen Chair in Molecular Medicine, and first director of the Institute of Molecular Medicine at The University of Texas Health Science Center at Houston.

A buffet luncheon will be provided to all attendees following the lecture.  Admittance to the luncheon will require a ticket that will be handed out to those in attendance.