Scientific Publications

Journal Publications

PET in the management of CAD

The Journal of Nuclear Medicine Vol. 37 No. 10 October 1996
Coronary Flow and Flow Reserve by PET Simplified for Clinical Applications Using Rubidium-82 or Nitrogen-13-Ammonia
Katsuya Yoshida, Nizar Mullani and K. Lance Gould

Business Briefing: US Cardiology 2006
Positron Emission Tomography in the Routine Management of Coronary Artery Disease
K Lance Gould, MD

Journal of Nuclear Cardiology November/December 2005
Assessing progression or regression of CAD: The role of perfusion imaging
K. Lance Gould, MD

The Journal of Nuclear Medicine Vol. 47 No. 1 January 2006
Mechanisms of Progression and Regression of Coronary Artery Disease by PET Related to Treatment Intensity and Clinical Events at Long-Term Follow-up
Stefano Sdringola, MD; Catalin Loghin, MD; Fernando Boccalandro, MD; and K. Lance Gould, MD

Current Opinions in Cardiology Vol 22 pp. 422-428 2007
Positron Emission Tomography in CAD
K. Lance Gould, MD

Journal of the American College of Cardiology-Cardiovascular Imaging August 2009
Does Coronary Flow Trump Coronary Anatomy?
K. Lance Gould, MD

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Lifestyle and Drugs

American Heart Journal November 2007
A 6 month randomized, double blind, placebo controlled, multi-center trial of high dose atorvastatin on myocardial perfusion abnormalities by positron emission tomography in coronary artery disease
Stefano Sdringola, MD,K. Lance Gould, MD, Linda Guilds Zamarka, Richard McLainc and Jennifer Garner

Circulation Vol 89, No 4 April 1994
Short-term Cholesterol Lowering Decreases Size and Severity of Perfusion Abnormalities by Positron Emission Tomography After Dipyridamole in Patients With Coronary Artery Disease
A Potential Noninvasive Marker of Healing Coronary Endothelium
K. Lance Gould, MD; James P. Martucci, MS; Dennis I. Goldberg, PhD; Mary Jane Hess, RN: R. Patterson Edens, PhD; Rifat Latifi, MD; Stanley J. Dudrick, MD

The Journal of the American Medical Association, Sept 20, 1995 Vol 274
Changes in Myocardial Perfusion Abnormalities by Positron Emission Tomography After Long-term, Intense Risk Factor Modification
K. Lance Gould, MD, Dean Ornish, MD, Larry Scherwitz, PhD, Shirley Brown, MD, Patterson Edens, PhD; Mary Jane Hess, RN; Nizar Mullani; Leonard Bolomey; Frank Dobbs, PhD; William T. Armstrong, MD; Terri Merritt, MS; Thomas Ports, MD; Stephen Sparler, MA; James Billings, PhD

Journal of the American College of Cardiology, Vol. 41, No. 2, 2003
Combined Intense Lifestyle and Pharmacologic Lipid Treatment Further Reduce Coronary Events and Myocardial Perfusion Abnormalities Compared With Usual-Care Cholesterol- Lowering Drugs in Coronary Artery Disease
Stefano Sdringola, MD, FACC, Keiichi Nakagawa, MD, Yuko Nakagawa, MD, S. Wamique Yusuf, MBBS, MRCP, Fernando Boccalandro, MD, Nizar Mullani, BS, Mary Haynie, RN, MBA, Mary Jane Hess, RN, K. Lance Gould, MD, FACC

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Early and Diffuse CAD

The Journal of Nuclear Medicine Vol. 46 No. 9 September 2005
Clinical Evaluation of a New Concept: Resting Myocardial Perfusion Heterogeneity Quantified by Markovian Analysis of PET Identifies Coronary Microvascular Dysfunction and Early Atherosclerosis in 1,034 Subjects
Nils P. Johnson, MD; and K. Lance Gould, MD

Circulation Vol 101;1931-9, April 2000
Frequency and Clinical Implications of Fluid Dynamically Significant Diffuse Coronary Artery Disease Manifest as Graded, Longitudinal, Base-to-Apex Myocardial Perfusion Abnormalities by Noninvasive Positron Emission Tomography
K. Lance Gould, MD; Yuko Nakagawa, MD; Keiichi Nakagawa, MD; Stefano Sdringola, MD; Mary Jane Hess, RN; Mary Haynie, RN, MBA; Neal Parker, MS; Nizar Mullani, BS; Richard Kirkeeide, PhD

Circulation Vol 103:496-501, January 2001
High Prevalence of Myocardial Perfusion Abnormalities on Positron Emission Tomography in Asymptomatic Persons With a Parent or Sibling With Coronary Artery Disease
Stefano Sdringola, MD; Dhaval Patel, MD; K. Lance Gould, MD

J Nucl Cardiol 2001;8:580-90
16 A precise, three-dimensional atlas of myocardial perfusion correlated with coronary arteriographic anatomy
Yuko Nakagawa, MD,Keiichi Nakagawa, MD,Stefano Sdringola, MD,Nizar Mullani, BS,and K. Lance Gould, MD

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Technical issues with PET

Molecular Imaging
Shifted Helical CT to Optimize Cardiac PET-CT Co-Registration: Quantitative Improvement and Limitations
K. Lance Gould, MD

Absolute Myocardial Uptake
Systolic Diastolic Partial Volume Differences on ECG-Gated Rb-82 Cardiac PET for Partial Volume Correction of Absolute Myocardial Uptake
Nils P. Johnson, MD and K. Lance Gould, MD

The Journal of Nuclear Medicine Vol. 45 No. 6 June 2004
Common Artifacts in PET Myocardial Perfusion Images Due to Attenuation–Emission Misregistration: Clinical Significance, Causes, and Solutions
Catalin Loghin, MD; Stefano Sdringola, MD; and K. Lance Gould, MD

The Journal of Nuclear Medicine Vol. 49 No. 5 May 2008
Reducing Radiation Dose in Rest–Stress Cardiac PET/CT by Single Poststress Cine CT for Attenuation Correction: Quantitative Validation
K. Lance Gould, MD, Tinsu Pan, Catalin Loghin, MD, Nils P. Johnson, and Stefano Sdringola, MD

The Journal of Nuclear Medicine Vol. 48 No. 7 July 2007
Frequent Diagnostic Errors in Cardiac PET/CT Due to Misregistration of CT Attenuation and Emission PET Images: A Definitive Analysis of Causes, Consequences, and Corrections
K. Lance Gould, MD, Tinsu Pan, Catalin Loghin, MD, Nils P. Johnson, Ashrith Guha, and Stefano Sdringola, MD

JACC: Cardiovascular Imaging, Vol. 2, No. 5, 2009
Coronary Flow Reserve and Pharmacologic Stress Perfusion Imaging: Beginnings and Evolution
K. Lance Gould, MD